CAS No 31362-50-2 , Bombesin Search by region : Germany

Name: Bombesin
Synonyms: 108: PN: US20090175821 PAGE: 403 claimedprotein;L-Methioninamide,5-oxo-L-prolyl-L-glutaminyl-L-arginyl-L-leucylglycyl-L-asparaginyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valylglycyl-L-histidyl-L-leucyl-; 25: PN: WO2004075830 SEQID: 25 claimed protein; Bombesin 14;Alytesin,2-L-glutamine-6-L-asparagine- (8CI);Bombesin;
CAS Registry Number:31362-50-2
Density: 1.5g/cm³
Refractive index: 1.681
Water Solubility: 0.05 M acetic acid: 20 mg/mL, clear, colorless
Safety Statements: 22-24/25
Molecular Weight: 1619.8481
InchiKey: QXZBMSIDSOZZHK-UHFFFAOYSA-N
InChI: InChI=1S/C71H110N24O18S/c1-34(2)24-47(92-62(105)43(14-11-22-79-71(76)77)
89-64(107)45(15-18-52(72)96)90-63(106)44-17-20-55(99)85-44)61(104)81-31-
56(100)87-51(28-54(74)98)69(112)91-46(16-19-53(73)97)65(108)94-49(26-38-
29-80-41-13-10-9-12-40(38)41)66(109)84-37(7)60(103)95-58(36(5)6)70(113)
82-32-57(101)86-50(27-39-30-78-33-83-39)68(111)93-48(25-35(3)4)67(110)
88-42(59(75)102)21-23-114-8/h9-10,12-13,29-30,33-37,42-51,58,80H,11,
14-28,31-32H2,1-8H3,(H2,72,96)(H2,73,97)(H2,74,98)(H2,75,102)(H,78,
83)(H,81,104)(H,82,113)(H,84,109)(H,85,99)(H,86,101)(H,87,100)(H,88,
110)(H,89,107)(H,90,106)(H,91,112)(H,92,105)(H,93,111)(H,94,108)(H,95,
103)(H4,76,77,79)
Molecular Formula: C₇₁H₁₁₀N₂₄O₁₈S
Molecular Structure:

Related products

Select to

          
           31362-50-2 Bombesin
           Bombesin
 
             chemcube UG
             
              [Manufacturer]
Tel:  +49 (22 08) 7 75 04 06
Fax:  +49 (22 08) 7 75 02 30 /
+49 (32 12) 1 00 74 76
Address: chemcube UG
Salierweg 1
53859 Niederkassel
Germany null,nullGermany

           31362-50-2 BOMBESIN
           
             BIOTREND Chemikalien GmbH
             
              [Manufacturer]
Tel:  ++49 (0)2 21 9 49 83 20
Fax:  ++49 (0)2 21 9 49 83 25
Address: BIOTREND Chemikalien GmbH 
Eupener Str. 157 
D - 50933 Cologne 
Germany null,nullGermany

           31362-50-2 Bombesin
           
             POLYPEPTIDE
             
              [Manufacturers]
Tel: +49 5331 9561 0
Fax: +45 48207005
Address: PolyPeptide Laboratories A/S 3400 Hiller?d Denmark Hiller?d,Hiller?dGermany

           31362-50-2 Bombesin
           Bombesin
 
             CHEMOS GmbH
             
              [Manufacturer]
Tel:  0049 9402/9336 0
Fax:  0049 9402/9336 13
Address: CHEMOS GmbH 
Werner-von-Siemensstr. 3 
93128 Regenstauf 
Germany null,nullGermany

Select to

1/1

References of Bombesin

Title: Bombesin
CAS Registry Number: 31362-50-2
CAS Name: 2-L-Glutamine-6-L-asparaginealytesin
Molecular Formula: C71H110N24O18S
Molecular Weight: 1619.85
Percent Composition: C 52.64%, H 6.84%, N 20.75%, O 17.78%, S 1.98%
Literature References: Pharmacologically active tetradecapeptide found in skins of European amphibians of the family Discoglossidae, principally Bombina bombina and Bombina variegata variegata. Isoln and structure: A. Anastasi et al., Experientia 27, 166 (1971). Pharmacological activity: V. Erspamer et al., J. Pharm. Pharmacol. 22, 875 (1970). Synthesis: L. Bernardi et al., Experientia 27, 873 (1971). It is a potent stimulant of gastric and pancreatic secretions in mammals; a bombesin-like immunoreactive peptide is found in both brain and gut, cf. J. M. Polak et al., Lancet 1, 1109 (1976). Other actions include hypertensive reactions, antidiuresis, and hyperglycemic activity. Bombesin has been shown to have a strong effect on core temperature lowering in rats: M. Brown et al., Science 196, 996 (1977). High levels of intracellular bombesin have also been found in human small-cell lung carcinoma: T. W. Moody et al., ibid. 214, 1246 (1981). Brief review of chemistry, isoln, purification: V. Mutt, Biochem. Soc. Trans. 8, 11 (1980). Effect on suppression of food intake: J. Gibbs et al., Nature 282, 208 (1979). Pharmacological reviews: G. Bertaccini, Pharmacol. Rev. 28, 127 (1976); S. R. Bloom, J. M. Polak, Adv. Clin. Chem. 21, 177 (1980).

Derivative Type: Hydrochloride
Molecular Formula: C71H112Cl2N24O18S
Molecular Weight: 1692.77
Percent Composition: C 50.38%, H 6.67%, Cl 4.19%, N 19.86%, O 17.01%, S 1.89%
Properties: Cryst from 99% ethanol, mp 185° (dec). [a]D24 -20.6° (c = 0.65 in DMF-HMPT 8:2).
Melting point: mp 185° (dec)
Optical Rotation: [a]D24 -20.6° (c = 0.65 in DMF-HMPT 8:2)