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CAS No 321-64-2 , 1,2,3,4-tetrahydroacridin-9-amine

  • Name: 1,2,3,4-tetrahydroacridin-9-amine
  • Synonyms: Tetrahydroaminocrine;Tetrahydroaminoacridine; Romotal; 321-64-2;1,2,3,4-tetrahydroacridin-9-amine; Cognex; Tetrahydroaminacrine; Tetrahydroaminocrin;
  • CAS Registry Number:
  • Flash Point: 230.5°C
  • Boiling Point: 409.4°Cat760mmHg
  • Density: 1.195g/cm3
  • Safety Statements: Poison by ingestion, intraperitoneal, and subcutaneous routes. Mutation data reported. Human systemic effects: changes in blood cell count, fatty degeneration, liver function tests impaired. When heated to decomposition it emits toxic fumes of NOx.
  • Hazard Symbols: T
  • Flash Point: 230.5°C
  • EINECS: 206-291-2
  • Molecular Weight: 198.26366
  • InchiKey: YLJREFDVOIBQDA-UHFFFAOYSA-N
  • InChI: InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,
    7H,2,4,6,8H2,(H2,14,15)
  • Risk Statements: R25;
  • Molecular Formula: C13H14N2
  • Molecular Structure:CAS No:321-64-2 1,2,3,4-tetrahydroacridin-9-amine
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321-64-2 Tacrine

  • IUPAC NAME-1,2,3,4-tetrahydroacridin-9-amine MOLECULAR FORMULA-C13H14N2 MOLAR MASS-C13H14N2 Tacrine is a centrally acting anticholinesterase and indirect cholinergic. It was the first centrally-acting cholinesterase inhibitor approved for the treatme...
  • India Swapnroop Drugs & Pharmaceuticals [Manufacturer, Trading Company]
  • Tel: 91-240-6641875
  • Fax: 91-240-6641875
  • Address: Harsool Aurangabad,MaharashtraIndia

321-64-2 Tacrine hydrochloride

  • Tacrine hydrochloride
  • China Sunkingchem Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-28-88007744
  • Fax: +86-28-85193812
  • Address: A-703, Gaofa Building, Jiuxing Road 6#, Hi-Tech Zone 610041, Chengdu, Sichuan, China.610041 ChengduCHINA Chengdu,nullChina
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321-64-2 Tacrine

  • Tacrine, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,nullChina
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321-64-2 Tacrine hydrochloride

  • Tacrine hydrochloride, > 99%
  • Switzerland BIOTREND Chemicals AG [Manufacturer]
  • Tel: +41 44 805 76 76
  • Fax: +41 44 805 76 77
  • Address: BIOTREND Chemicals AG
    Unterdorfstr. 21b
    CH-8602 Wangen/Zuerich
    Switzerland null,nullSwitzerland
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321-64-2 9-Amino-1,2,3,4-tetrahydroacridine

  • 9-Amino-1,2,3,4-tetrahydroacridine
  • France Interchim S.A. [Importer/Exporter]
  • Tel: (33) 4 70 03 88 55
  • Fax: (33) 4 70 03 82 60
  • Address: 211, AVENUE, J.F. KENNEDY, MONTLUCON - 03100, ALLIER, FRANCE null,nullFrance
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321-64-2 Tacrine

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321-64-2 1,2,3,4-TETRAHYDROACRIDIN-9-AMINE

  • China Syntechem Co.,Ltd [Manufacturer]
  • Tel: +86-519-89882658
  • Fax: +86-519-8512 5369
  • Address: Syntechem Co.,Ltd
    18 South Zhulin Rd.
    Tianning district,Changzhou
    Jiangsu China 213022 null,nullChina
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321-64-2 9-Amino-1,2,3,4-tetrahydroacridine hydrochloride hydrate

  • 9-Amino-1,2,3,4-tetrahydroacridine hydrochloride hydrate Tacrine hydrochloride hydrate THA 9-Amino-1,2,3,4-tetrahydroacridine, Hydrochloride Hydrate Tacrine Tacrine hydrochloride 9-Amino-1,2,3,4-tetrahydroacridine Acridine 1,2,3,4-tetrahydro-9-amino ...
  • Netherlands Vitas-M Laboratory [Manufacturer]
  • Tel: +31 (0)55 50 500 33
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  • Address: PO Box 200477302 HA ApeldoornNETHERLANDS 7302 HA Apeldoorn,nullNetherlands
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321-64-2 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE TLC

  • 9-AMINO-1,2,3,4-TETRAHYDROACRIDINE TLC
  • India CHEMPURE [Manufacturer]
  • Tel: 0091-22-26764461/ 0091-22-26764462
  • Fax: 0091-22-26764023
  • Address: 328,Ashirwad Industrial Estate Bldg No.3 Ram Mandir Road,Goregaon (West) Mumbai- 400104 India Tel:0091-22-26764461 0091-22-26764462 0091-22-26764139 Fax:0091-22-26764023 Cell: 09821531478 email: chempure@bom2.vsnl.net.in 400104 MUMBAI MUMBAI,nullIndia
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321-64-2 1,2,3,4-Tetrahydro-5-aminoacridine hydrochloride

  • 1,2,3,4-Tetrahydro-5-aminoacridine hydrochlorideTacrine hydrochloride, >99%
  • United Kingdom Tocris Bioscience [Manufacturer]
  • Tel: + 44 (0)117 916 3333
  • Fax: + 44 (0)117 916 3344
  • Address: Tocris Bioscience Tocris House Hung Road BS11 9XJ BristolUNITED KINGDOM BS11 9XJ Bristol,nullUnited Kingdom
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References of 1,2,3,4-tetrahydroacridin-9-amine
Title: Tacrine
CAS Registry Number: 321-64-2
CAS Name: 1,2,3,4-Tetrahydro-9-acridinamine
Synonyms: 9-amino-1,2,3,4-tetrahydroacridine; 5-amino-1,2,3,4-tetrahydroacridine; 1,2,3,4-tetrahydro-5-aminoacridine
Molecular Formula: C13H14N2
Molecular Weight: 198.26
Percent Composition: C 78.75%, H 7.12%, N 14.13%
Literature References: Centrally active anticholinesterase; cognition enhancer. Prepn: Braun et al., Ber. 64, 227 (1931); Albert, Gledhill, J. Soc. Chem. Ind. 64, 169T (1945); Petrow, J. Chem. Soc. 1947, 634; J. A. Moore, L. D. Kornreich, Tetrahedron Lett. 4, 1277 (1963). Pharmacology and toxicity: S. Gershon, F. H. Shaw, J. Pharm. Pharmacol. 10, 638 (1958). Enzyme inhibiting activity: P. N. Kaul, ibid. 14, 243 (1962). Neuropharmacology: B. Drukarch et al., Life Sci. 42, 1011 (1988). Spectrofluorimetric determn in serum: I. Aparico et al., Analyst 123, 1575 (1998). Clinical trial in severe Alzheimer's disease: W. K. Summers et al., N. Engl. J. Med. 315, 1241 (1986). See also: ibid. 316, 1603-1606. Clinical evaluation of reduced mortality in dementia: B. R. Ott, K. L. Lapane, J. Am. Geriatr. Soc. 50, 35 (2002). Review of pharmacology and clinical uses: W. K. Summers et al., Clin. Toxicol. 16, 269-281 (1980); of cholinesterase inhibition in Alzheimer's disease: N. Qizilbash et al., J. Am. Med. Assoc. 280, 1777-1782 (1998).
Properties: Octahedra from very dil alc, mp 183-184°.
Melting point: mp 183-184°
 
Derivative Type: Hydrochloride
CAS Registry Number: 1684-40-8
Trademarks: Cognex (Warner-Lambert); THA (Woods)
Molecular Formula: C13H14N2.HCl
Molecular Weight: 234.72
Percent Composition: C 66.52%, H 6.44%, N 11.93%, Cl 15.10%
Properties: Yellow needles from concd hydrochloric acid, mp 283-284°. Bitter taste. Sol in water. pH of 1.5% soln: 4.5-6. uv max (acetate buffer, pH 1-7): 242 nm. Emission max: 362 nm.
Melting point: mp 283-284°
Absorption maximum: uv max (acetate buffer, pH 1-7): 242 nm
 
Therap-Cat: Nootropic. Antidote to curare. Respiratory stimulant.
Keywords: Antidote (Curare); Cholinesterase Inhibitor; Nootropic; Respiratory Stimulant.