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CAS No 34273-10-4 , 2-[[1-[2-[[2-[[2-[[2-[[5-(diaminomethylideneamino)-2-[[2-(methylamino)
acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-
hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]-3-(1H-imidazol-5-
yl)propanoyl]pyrrolidine-2-carbonyl]amino]propanoic acid

  • Name: 2-[[1-[2-[[2-[[2-[[2-[[5-(diaminomethylideneamino)-2-[[2-(methylamino)
    acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-
    hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]-3-(1H-imidazol-5-
    yl)propanoyl]pyrrolidine-2-carbonyl]amino]propanoic acid
  • Synonyms: Saralasinum [INN-Latin]; Saralasin [INN:BAN]; Saralasina [INN-Spanish];2-[[1-[2-[[2-[[2-[[2-[[5-(diaminomethylideneamino)-2-[[2-(methylamino)
    acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-
    hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]-3-(1H-imidazol-5-
    yl)propanoyl]pyrrolidine-2-carbonyl]amino]propanoic acid; Saralasine [INN-French]; Sar-Arg-Val-Tyr-Val-His-Pro-Ala;
  • CAS Registry Number:
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.42 g/cm3
  • Refractive index: 1.653
  • Flash Point: °C
  • Molecular Weight: 912.0466
  • InchiKey: PFGWGEPQIUAZME-UHFFFAOYSA-N
  • InChI: InChI=1S/C42H65N13O10/c1-22(2)33(53-35(58)28(50-32(57)20-45-6)9-7-15-47-
    42(43)44)38(61)51-29(17-25-11-13-27(56)14-12-25)36(59)54-34(23(3)4)39
    (62)52-30(18-26-19-46-21-48-26)40(63)55-16-8-10-31(55)37(60)49-24(5)41
    (64)65/h11-14,19,21-24,28-31,33-34,45,56H,7-10,15-18,20H2,1-6H3,(H,46,
    48)(H,49,60)(H,50,57)(H,51,61)(H,52,62)(H,53,58)(H,54,59)(H,64,65)(H4,
    43,44,47)
  • Molecular Formula: C42H65N13O10
  • Molecular Structure:CAS No:34273-10-4 2-[[1-[2-[[2-[[2-[[2-[[5-(diaminomethylideneamino)-2-[[2-(methylamino)<br />acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-<br />hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]-3-(1H-imidazol-5-<br />yl)propanoyl]pyrrolidine-2-carbonyl]amino]propanoic acid

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References of 2-[[1-[2-[[2-[[2-[[2-[[5-(diaminomethylideneamino)-2-[[2-(methylamino)
acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-
hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]-3-(1H-imidazol-5-
yl)propanoyl]pyrrolidine-2-carbonyl]amino]propanoic acid
Title: Saralasin
CAS Registry Number: 34273-10-4
CAS Name: 1-(N-Methylglycine)-5-L-valine-8-L-alanineangiotensin II
Synonyms: N-[1-[N-[N-[N-[N-[N2-(N-methylglycyl)-L-arginyl]-L-valyl]-L-tyrosyl]-L-valyl]-L-histidyl]-L-prolyl]-L-alanine; 1-sar-8-ala-angiotensin II
Molecular Formula: C42H65N13O10
Molecular Weight: 912.05
Percent Composition: C 55.31%, H 7.18%, N 19.96%, O 17.54%
Literature References: A specific antagonist of angiotensin II. Prepn: Sipos et al., DE 2127393 corresp to US 3751404 (1972, 1973 to Norwich Pharmacal). Activity studies: Pals et al., Circ. Res. 29, 673 (1971); Pals, Fulton, Arch. Int. Pharmacodyn. Ther. 204, 20 (1973); Solomon, Buckley, J. Pharm. Sci. 63, 1109 (1974); Streeten et al., N. Engl. J. Med. 292, 657 (1975). Comprehensive review of the acetate: C. T. Huang et al., in Pharmacological and Biochemical Properties of Drug Substances vol. 3, M. E. Goldberg, Ed. (Am. Pharm. Assoc., Washington, DC, 1981) pp 176-225.
 
Derivative Type: Hydrated acetate
CAS Registry Number: 39698-78-7
Synonyms: Saralasin acetate
Manufacturers' Codes: P-113
Trademarks: Sarenin (Procter & Gamble)
Properties: Described as C42H65N13O10.xC2H4O2.xH2O. Fluffy white powder, mp 256°. Sol in water, 5% aq dextrose, 90-95% aq alcohol. LD50 i.v. in male mice: 1171 mg/kg (Huang).
Melting point: mp 256°
Toxicity data: LD50 i.v. in male mice: 1171 mg/kg (Huang)
 
Therap-Cat: Antihypertensive, diagnostic aid (renin-dependent hypertension).
Keywords: Antihypertensive; Diagnostic Aid.