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CAS No 35457-80-8 , medemycin

  • Name: medemycin
  • Synonyms: medemycin;Midecamycin;
  • CAS Registry Number:
  • Flash Point: 482.4°C
  • Boiling Point: 874°Cat760mmHg
  • Density: 1.21g/cm3
  • Refractive index: 1.536
  • Safety Statements: Moderately toxic by intravenous route. Mildly toxic by ingestion. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: 482.4°C
  • EINECS: 252-578-0
  • Molecular Weight: 813.97
  • InChI: InChI=1/C41H67NO15/c1-11-30(45)54-29-21-32(47)51-24(4)16-14-13-15-17-28(44)23(3)20-27(18-19-43)37(38(29)50-10)57-40-35(48)34(42(8)9)36(25(5)53-40)56-33-22-41(7,49)39(26(6)52-33)55-31(46)12-2/h13-15,17,19,23-29,33-40,44,48-49H,11-12,16,18,20-22H2,1-10H3/b14-13+,17-15-/t23?,24?,25-,26-,27?,28?,29?,33+,34-,35-,36-,37?,38?,39-,40+,41-/m1/s1
  • Molecular Formula: C41H67NO15
  • Molecular Structure:CAS No:35457-80-8 medemycin
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35457-80-8 Midecamycin

  • Midecamycin, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,China
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35457-80-8 Midecamycin

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35457-80-8 Midecamycin

  • China Facus Pharmaceutical Co., Ltd. [Manufacturers]
  • Tel: +86-(574)-6237-8411
  • Fax: +86-(574)-6237-8410
  • Address: 24Fl, Yuanjing Building, Beilun, Ningbo, Zhejiang 315800, Ningbo,ZhejiangChina
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35457-80-8 Midecamycin

  • Midecamycin, 99%
  • China Tianjin Pharmacn Science Co., Ltd. [Manufacturer]
  • Tel: 86-22-23359620/ 86-13612042162 (mobile)
  • Fax: 86-22-23359620
  • Address: 1006 Sinochem Building, 707 Lianmeng RD, Shijiazhuang 050061, Hebei, China ,China
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35457-80-8 Midecamycin

  • United States Tecoland Corporation []
  • Tel: +1-(732)-603-9577
  • Fax: +1-(732)-906-1522
  • Address: 100 Menlo Park Drive, Suite 316, Edison, New Jersey 08837-2428, ,United States
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35457-80-8 Midecamycin

  • Midecamycin
  • United States AvaChem Scientific LLC [Manufacturer]
  • Tel: 210-667-3815
  • Fax: 210-764-2240
  • Address: P.O.Box 78044278278 San Antonio, TexasUNITED STATES 78278 San Antonio, Texas,United States
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35457-80-8 Midecamycin

  • Midecamycin
  • China Hallopharma [Manufacturer]
  • Tel: 0086-23-67030808
  • Fax: 0086-23-67030818
  • Address: 17F,Venus Science Incubate Center,No.60 Xingguang Road,New North Zone,401121 ChongqingCHINA Chongqing,China
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35457-80-8 Midecamycin

  • Midecamycin
  • China Inter-Chemical [Manufacturer]
  • Tel: 0086-23-67030808
  • Fax: 0086-23-67030818
  • Address: 17F,Venus Science Incubate Center,No.60 Xingguang Road,New North Zone,401121 ChongqingCHINA Chongqing,China
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35457-80-8 medemycin

  • Hong kong Leawell International Limited [Importer/Exporter]
  • Tel: +852-(2576)-0298
  • Fax: +852-(2895)-4635
  • Address: 18/F Catic Plaza, 8 Causeway Road Causeway Bay, Guangzhou,GuangdongHong kong
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35457-80-8 Midecamycin

  • Midecamycin
  • China Sinopharma [Manufacturer]
  • Tel: 0311-86671742
  • Fax: 0311-86046662
  • Address: 219 East Heping Road, Shijiazhuang, Hebei, China050015 ShijiangzhuangCHINA Shijiangzhuang,China
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References of medemycin
Title: Midecamycins
Literature References: Macrolide antibiotic complex produced by Streptomyces mycarofaciens nov. sp. Isoln and characterization of the major component, midecamycin A1: T. Tsuruoka et al., JP 71 28834; eidem, US 3761588 (1971, 1973 both to Meiji); eidem, J. Antibiot. 24, 319, 452 (1971). Structure: I. Shigeharu et al., ibid. 460. Isoln, properties, structures of the minor components, midecamycins A2, A3, A4: T. Tsuruoka et al., ibid. 476, 526. Enzymatic interconversion of A1 and A3: Y. Matsuhashi et al., ibid. 32, 777 (1979). Metabolism: T. Shomura et al., Chem. Pharm. Bull. 22, 2427 (1974). Pharmacokinetics: K. Fukaya et al., Chemotherapy (Tokyo) 21, 692 (1973). Pharmacology: K. Mashimo et al., ibid. 729. Antibacterial activity: T. Watanabe et al., ibid. 25, 1624 (1977). Toxicity and teratogenicity study in mice: M. Moriguchi et al., Jpn. J. Antibiot. 15, 187, 193 (1972), C.A. 78, 11652a, 11653b (1973).
 
Derivative Type: Midecamycin A1
CAS Registry Number: 35457-80-8
Synonyms: Leucomycin V 3,4B-dipropanoate; espinomycin A; mydecamycin; turimycin P3
Manufacturers' Codes: SF-837; YL-704B1
Trademarks: Aboren (Promeco); Medemycin (Meiji); Midecin (Farmaka); Momicine (Morrith); Myoxam (Menarini); Normicina (Meiji Seika); Rubimycin (Nikken)
Molecular Formula: C41H67NO15
Molecular Weight: 813.97
Percent Composition: C 60.50%, H 8.30%, N 1.72%, O 29.48%
Properties: Colorless needles from benzene, mp 155-156° (after drying at 80° for 8 hrs in vacuo). [a]D23 -67° (c = 1 in ethanol). uv max (ethanol): 232 nm (E1%1cm 325). Weakly basic; pKa¢ 6.9 in 50% aq ethanol. Sol in methanol, ethanol, acetone, chloroform, ethyl acetate, benzene, ethyl ether, acidic water. Practically insol in n-hexane, petr ether, water.
Melting point: mp 155-156° (after drying at 80° for 8 hrs in vacuo)
pKa: pKa¢ 6.9 in 50% aq ethanol
Optical Rotation: [a]D23 -67° (c = 1 in ethanol)
Absorption maximum: uv max (ethanol): 232 nm (E1%1cm 325)
 
Derivative Type: Midecamycin A3
CAS Registry Number: 36025-69-1
Synonyms: 9-Deoxy-9-oxoleucomycin V 3,4B-dipropanoate; antibiotic SF-837A3
Molecular Formula: C41H65NO15
Molecular Weight: 811.95
Percent Composition: C 60.65%, H 8.07%, N 1.73%, O 29.56%
Properties: White powder, mp 122-125°. [a]D22 -44° (c = 1 in ethanol). uv max (ethanol): 280 nm (E1%1cm 295). pKa¢ 7.0 in 50% aq ethanol. Solubilities similar to midecamycin A1.
Melting point: mp 122-125°
pKa: pKa¢ 7.0 in 50% aq ethanol
Optical Rotation: [a]D22 -44° (c = 1 in ethanol)
Absorption maximum: uv max (ethanol): 280 nm (E1%1cm 295)
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); Macrolides.