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CAS No 356-12-7 , Fluocinonide Search by region : China

  • Name: Fluocinonide
  • Synonyms: Cortalar; Lidex;Fluocinonide; Topsymin; Vanos; Straderm; Metosyn;Fluocinolide; Biscosal; Bestasone;
  • CAS Registry Number:
  • Transport: UN 2811 6.1/PG 2
  • Melting Point: 309 ºC
  • Flash Point: 311.3°C
  • Boiling Point: 591.1°Cat760mmHg
  • Density: 1.34g/cm3
  • Refractive index: 1.56
  • Safety Statements: Poison by ingestion, subcutaneous, and intraperitoneal routes. Mutation data reported. Experimental reproductive effects. A steroid. When heated to decomposition it emits toxic fumes of F−.
  • Hazard Symbols: T+: Very toxic;
  • Flash Point: 311.3°C
  • EINECS: 206-597-6
  • Molecular Weight: 494.524886
  • InchiKey: WJOHZNCJWYWUJD-IUGZLZTKSA-N
  • InChI: InChI=1S/C26H32F2O7/c1-13(29)33-12-20(32)26-21(34-22(2,
    3)35-26)10-15-16-9-18(27)17-8-14(30)6-7-23(17,4)25(16,28)19(31)11-24(15,
    26)5/h6-8,15-16,18-19,21,31H,9-12H2,1-5H3/t15-,16-,18-,19-,21+,23-,24-,
    25-,26+/m0/s1
  • Risk Statements: 28-63
  • Molecular Formula: C26H32F2O7
  • Molecular Structure:CAS No:356-12-7 Fluocinonide

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References of Fluocinonide
Title: Fluocinonide
CAS Registry Number: 356-12-7
CAS Name: (6a,11b,16a)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
Synonyms: 6a,9-difluoro-11b,16a,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, cyclic 16,17-acetal with acetone, 21-acetate; 21-acetoxy-6a,9a-difluoro-11b-hydroxy-16a,17a-isopropylidenedioxy-1,4-pregnadiene-3,20-dione; 16a,17a-isopropylidene-6a-fluorotriamcinolone 21-acetate; fluocinolide (obsolete); fluocinolide acetate (obsolete); fluocinolone acetonide acetate
Trademarks: Biscosal (Ohta); Dermaplus (Ripari-Gero); Lidex (Syntex); Metosyn (Zeneca); Synalate (rescinded) (Syntex); Straderm (ITA); Topsym (Grñenthal); Topsymin (Grñenthal); Topsyne (Cassenne); Topsyn (Syntex)
Molecular Formula: C26H32F2O7
Molecular Weight: 494.52
Percent Composition: C 63.15%, H 6.52%, F 7.68%, O 22.65%
Literature References: Prepn: GB 916996 (1963 to Olin Mathieson), C.A. 59, 1716b (1963); H. J. Ringold, G. Rosenkranz, US 3124571; H. J. Ringold et al., US 3126375 (both 1964 to Syntex); J. Fried, US 3197469 (1965 to Pharm. Res. Prod.). NMR: A. D. Cross, P. W. Landis, J. Am. Chem. Soc. 86, 4005 (1964).
Properties: Crystals from methanol. mp 308-311°. [a]D +83° (chloroform). uv max: 237 nm (log e 4.18).
Melting point: mp 308-311°
Optical Rotation: [a]D +83° (chloroform)
Absorption maximum: uv max: 237 nm (log e 4.18)
Therap-Cat: Anti-inflammatory; glucocorticoid.
Keywords: Glucocorticoid.