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CAS No 3922-90-5 , OLEANDOMYCIN

  • Name: OLEANDOMYCIN
  • Synonyms: OLEANDOMYCIN;
  • CAS Registry Number:
  • Flash Point: 439.2°C
  • Boiling Point: 802.6°C at 760 mmHg
  • Density: 1.21g/cm3
  • Refractive index: 1.533
  • Safety Statements: A poison by intravenous route. Low toxicity by ingestion. When heated to decomposition it emits toxic vapors of NOx.
  • Flash Point: 439.2°C
  • EINECS: 223-495-7
  • Molecular Weight: 687.8583
  • InChI: InChI=1/C35H61NO12/c1-16-14-35(15-43-35)32(40)19(4)27(37)18(3)22(7)46-33(41)21(6)31(47-26-13-25(42-11)28(38)23(8)45-26)20(5)30(16)48-34-29(39)24(36(9)10)12-17(2)44-34/h16-31,34,37-39H,12-15H2,1-11H3/t16-,17+,18-,19+,20+,21+,22+,23-,24-,25-,26-,27-,28-,29+,30-,31-,34-,35-/m0/s1
  • Molecular Formula: C35H61NO12
  • Molecular Structure:CAS No:3922-90-5 OLEANDOMYCIN

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3922-90-5 OLEANDOMYCIN

  • China HANGZHOU THINK CHEMICAL CO. [Manufacturer]
  • Tel: +86-571-81956191/ +86-571-81956192
  • Fax: +86-571-81956190
  • Address: 425 MOGAN HILL ROAD ,
    HANGZHOU, 310011 CHINA null,nullChina
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3922-90-5 OLEANDOMYCIN

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China null,nullChina
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References of OLEANDOMYCIN
Title: Oleandomycin
CAS Registry Number: 3922-90-5
Manufacturers' Codes: PA-105
Trademarks: Amimycin; Landomycin; Romicil
Molecular Formula: C35H61NO12
Molecular Weight: 687.86
Percent Composition: C 61.11%, H 8.94%, N 2.04%, O 27.91%
Literature References: Antibiotic substance produced by Streptomyces antibioticus no. ATCC 11891: Sobin et al.; Ratajak, Nubel, US 2757123; US 2842481 (1956, 1958 to Pfizer). Structure: Hochstein et al., J. Am. Chem. Soc. 82, 3225 (1960). Absolute configuration: Celmer, ibid. 87, 1797 (1965); Celmer, Hobbs, Carbohydr. Res. 1, 137 (1965); S. Omura et al., Tetrahedron Lett. 1975, 2939. Synthetic study: K. Tatsuta et al., ibid. 29, 3975 (1988). Activity: Hahn, Antibiotics 1, 378, 755 (1967). For a review of macrolide antibiotics see Keller-Schierlein, Fortschr. Chem. Org. Naturst. 30, 313-460 (1973). Toxicity: H. Sous et al., Arzneim.-Forsch. 8, 386 (1958).
Properties: White amorphous powder. uv max (methanol): 286-289 nm. Moderately sol in water. Sol in dil acids. Freely sol in methanol, ethanol, butanol, acetone. Practically insol in hexane, carbon tetrachloride, dibutyl ether.
Absorption maximum: uv max (methanol): 286-289 nm
 
Derivative Type: Hydrochloride
CAS Registry Number: 6696-47-5
Molecular Formula: C35H61NO12.HCl
Molecular Weight: 724.32
Percent Composition: C 58.04%, H 8.63%, N 1.93%, O 26.51%, Cl 4.89%
Properties: Long needles from ethyl acetate, mp 134-135°. [a]D25 -54° (methanol). Freely sol in water. Forms various cryst hydrates. LD50 in mice, rats (mg/kg): 8200, >10000 orally; 600, 400 i.v. (Sous).
Melting point: mp 134-135°
Optical Rotation: [a]D25 -54° (methanol)
Toxicity data: LD50 in mice, rats (mg/kg): 8200, >10000 orally; 600, 400 i.v. (Sous)
 
Derivative Type: Phosphate
CAS Registry Number: 7060-74-4
Trademarks: Matromycin (Pfizer)
Molecular Formula: C35H61NO12.H3PO4
Molecular Weight: 785.85
Percent Composition: C 53.49%, H 8.21%, N 1.78%, O 32.57%, P 3.94%
 
Derivative Type: Triacetyl deriv see Troleandomycin
 
Therap-Cat: Antibacterial.
Therap-Cat-Vet: Antibacterial.
Keywords: Antibacterial (Antibiotics); Macrolides.