Home > Name List By other > (3-hydrazinyl-7,8-dihydro-5H-pyrido[4, 3-c]pyridazin-6-yl)-phenylmethanone

CAS No 39715-02-1 , (3-hydrazinyl-7,8-dihydro-5H-pyrido[4,
3-c]pyridazin-6-yl)-phenylmethanone

  • Name: (3-hydrazinyl-7,8-dihydro-5H-pyrido[4,
    3-c]pyridazin-6-yl)-phenylmethanone
  • Synonyms: Endralazina [INN-Spanish];Miretilan; Endralazine [INN:BAN]; 39715-02-1;(3-hydrazinyl-7,8-dihydro-5H-pyrido[4,
    3-c]pyridazin-6-yl)-phenylmethanone; ENDRALAZINE; Endralazinum [INN-Latin];
  • CAS Registry Number:
  • Flash Point: 300.1°C
  • Boiling Point: 572.6°Cat760mmHg
  • Density: 1.364g/cm3
  • Refractive index: 1.7
  • Flash Point: 300.1°C
  • Molecular Weight: 269.3018
  • InchiKey: ALAXZYHFVBSJKZ-UHFFFAOYSA-N
  • InChI: InChI=1S/C14H15N5O/c15-16-13-8-11-9-19(7-6-12(11)17-18-13)14(20)10-4-2-
    1-3-5-10/h1-5,8H,6-7,9,15H2,(H,16,18)
  • Molecular Formula: C14H15N5O
  • Molecular Structure:CAS No:39715-02-1 (3-hydrazinyl-7,8-dihydro-5H-pyrido[4,<br />3-c]pyridazin-6-yl)-phenylmethanone

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39715-02-1 ENDRALAZINE

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39715-02-1 Endralazine

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References of (3-hydrazinyl-7,8-dihydro-5H-pyrido[4,
3-c]pyridazin-6-yl)-phenylmethanone
Title: Endralazine
CAS Registry Number: 39715-02-1
CAS Name: 6-Benzoyl-5,6,7,8-tetrahydropyrido[4,3-c]pyridazin-3(2H)-one hydrazone
Synonyms: 6-benzoyl-3-hydrazino-5,6,7,8-tetrahydropyrido[4,3-c]pyridazine
Molecular Formula: C14H15N5O
Molecular Weight: 269.30
Percent Composition: C 62.44%, H 5.61%, N 26.01%, O 5.94%
Literature References: Prepn: E. Schenker, DE 2221808; idem, US 3838125 (1972, 1974 both to Sandoz); E. Schenker, R. Salzmann, Arzneim.-Forsch. 29, 1835 (1979). Pharmacology: R. Salzmann et al., ibid. 1843. Hemodynamic study: H. U. Lehmann et al., Z. Cardiol. 66, 203 (1977). HPLC determn in human plasma: P. A. Reece et al., J. Chromatogr. 225, 151 (1981). Clinical pharmacology: F. C. Reubi, Eur. J. Clin. Pharmacol. 13, 185 (1978). Clinical study in hypertension: H. U. Lehmann et al., Med. Welt 29, 1007 (1978).
Properties: Crystals from acetonitrile/water, mp 220-223° (dec).
Melting point: mp 220-223° (dec)
 
Derivative Type: Methanesulfonate
CAS Registry Number: 65322-72-7
Synonyms: Endralazine mesylate
Manufacturers' Codes: BQ 22-708
Trademarks: Miretilan (Sandoz)
Molecular Formula: C14H15N5O.CH3SO3H
Molecular Weight: 365.41
Percent Composition: C 49.30%, H 5.24%, N 19.17%, O 17.51%, S 8.78%
Properties: Cryst, mp 185-188° (dec).
Melting point: mp 185-188° (dec)
 
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive; Hydrazines/Phthalazines.