Home > Name List By other > [(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2, 3-dihydro-1,5-benzothiazepin-3-yl] acetate

CAS No 42399-41-7 , [(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,
3-dihydro-1,5-benzothiazepin-3-yl] acetate

  • Name: [(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,
    3-dihydro-1,5-benzothiazepin-3-yl] acetate
  • Synonyms: Endrydil; Dilta-Hexal; Anoheal;[(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,
    3-dihydro-1,5-benzothiazepin-3-yl] acetate; Dilcontin; Dilticard; d-cis-Diltiazem; Dilzen; Acalix;Cardizem;
  • CAS Registry Number:
  • Density: 1.26 g/cm3
  • EINECS: 255-796-4
  • Molecular Weight: 414.51784
  • InchiKey: HSUGRBWQSSZJOP-RTWAWAEBSA-N
  • InChI: InChI=1S/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-
    6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,
    21+/m1/s1
  • Molecular Formula: C22H26N2O4S
  • Molecular Structure:CAS No:42399-41-7 [(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,<br />3-dihydro-1,5-benzothiazepin-3-yl] acetate
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42399-41-7 DILTIAZEM

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
    17 Walnut St., Tai Kok Tsui, Kln,
    Hong Kong ,Hong kong
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42399-41-7 8482.22-K-ME DILTIAZEM (FREE BASE)

  • Germany Campro Scientific GmbH [Manufacturer]
  • Tel: +49.(0)30.629.01.89.0 (Germany)/ +31.(0)318.529.437 (Netherlands)
  • Fax: +49.(0)30.629.01.89.89
    +31.(0)318.542.181
  • Address: Campro Scientific GmbH
    Postfach 36 20 65
    D-10972 Berlin
    Germany
    Tel. +49.(0)30.629.01.89.0
    Fax +49.(0)30.629.01.89.89
    info@campro.eu ,Germany
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42399-41-7 DILTIAZEM (FREE BASE)

  • Norway Chiron AS [Manufacturer]
  • Tel: +47 73 87 44 90
  • Fax: +47 73 87 44 99
  • Address: Chiron AS
    Stiklestadveien 1
    N-7041 Trondheim
    Norway ,Norway
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42399-41-7 Diltiazem

  • Germany Fox Chemicals GmbH [Manufacturer]
  • Tel: +49.7240.927151/ +49.160.95781845 (Mobile)
  • Fax: +49.7240.927150
  • Address: Fox Chemicals GmbH
    Bockstalstr.10 A
    D-76327 Pfinztal-Germany ,Germany
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42399-41-7 Diltiazem

  • United States Parchem Trading [Manufacturer]
  • Tel: 914.654.6800
  • Fax: 914.654.6899
  • Address: Parchem Trading Ltd.
    415 Huguenot Street
    New Rochelle, NY 10801 ,United States
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42399-41-7 Diltiazem

  • China Qingdao Chinaoil Co., Ltd []
  • Fax: +86-532-85713888 85723888
  • Address: 22/F,Golden Light Tower,No.56, Xianggang Zhong Road, Qingdao 266071, China ,China
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42399-41-7 Diltiazem

  • China Huei-Ho International Co., Ltd. [Importer/Exporter]
  • Tel: +86-(21)-6273-7219, 6273-6279
  • Fax: +86-(21)-6129-4387, 62735948
  • Address: 20B,No.2,Lane 600,Peakway Tower,Tianshan Road, Shanghai, shanghai 200051, ,ShanghaiChina
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References of [(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,
3-dihydro-1,5-benzothiazepin-3-yl] acetate
Title: Diltiazem
CAS Registry Number: 42399-41-7
CAS Name: (2S-cis)-3-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
Synonyms: (+)-cis-5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate (ester)
Molecular Formula: C22H26N2O4S
Molecular Weight: 414.52
Percent Composition: C 63.74%, H 6.32%, N 6.76%, O 15.44%, S 7.74%
Literature References: Calcium channel blocker with vasodilating activity. Prepn (unspec stereochem): H. Kugita et al., DE 1805714; eidem, US 3562257 (1969, 1971 both to Tanabe Seiyaku); eidem, Chem. Pharm. Bull. 19, 595 (1971). Resolution of optical isomers: H. Inoue et al., Yakugaku Zasshi 93, 729 (1973), C.A. 79, 66331w (1974). Stereospecific synthesis: K. Igarashi, T. Honma, DE 3415035; eidem, US 4552695 (1984, 1985 both to Shionogi). Structure-activity studies: Sato et al., Arzneim.-Forsch. 21, 1338 (1971); T. Nagao et al., Chem. Pharm. Bull. 21, 92 (1973). Pharmacology and toxicity: eidem, Jpn. J. Pharmacol. 22, 467 (1972). Metabolism: Meshi et al., Chem. Pharm. Bull. 19, 1546 (1971). Review of synthesis and pharmacology: H. Inoue, T. Nagao, Chron. Drug Discovery 3, 207-238 (1993). Comprehensive description: D. J. Mazzo et al., Anal. Profiles Drug Subs. Excip. 23, 53-98 (1994). Review of pharmacology and efficacy in angina: M. Chaffman, R. N. Brogden, Drugs 29, 387-454 (1985); in hypertension: M. R. Weir, J. Clin. Pharmacol. 35, 220-232 (1995). Comparative clinical trial in prevention of complications of hypertension: L. Hansson et al., Lancet 356, 359 (2000).
 
Derivative Type: Hydrochloride
CAS Registry Number: 33286-22-5
Manufacturers' Codes: CRD-401
Trademarks: Adizem (Napp); Altiazem (Lusofarmaco); Angizem (Inverni); Cardizem (Biovail); Deltazen (Sanofi-Aventis); Dilacor XR (Watson); Diladel (Polifarma); Dilpral (Orion); Dilrene (Sanofi-Aventis); Dilzem (Gecke); Dilzene (Sigma-Tau); Masdil (Esteve); Tiazac (Forest); Tildiem (Sanofi-Aventis); Zilden (Pharmacia)
Molecular Formula: C22H26N2O4S.HCl
Molecular Weight: 450.98
Percent Composition: C 58.59%, H 6.03%, N 6.21%, O 14.19%, S 7.11%, Cl 7.86%
Properties: Fine needles from ethanol-isopropanol, mp 207.5-212°. Odorless, with a bitter taste. [a]D24 +98.3 ± 1.4° (c = 1.002 in methanol). Freely sol in water, methanol, chloroform, formic acid; slightly sol in abs ethanol. Practically insol in benzene. Insol in ether. LD50 in male, female mice, male, female rats (mg/kg): 61, 58, 38, 39 i.v.; 260, 280, 520, 550 s.c.; 740, 640, 560, 610 orally (Nagao, 1972).
Melting point: mp 207.5-212°. Odorless
Optical Rotation: [a]D24 +98.3 ± 1.4° (c = 1.002 in methanol)
Toxicity data: LD50 in male, female mice, male, female rats (mg/kg): 61, 58, 38, 39 i.v.; 260, 280, 520, 550 s.c.; 740, 640, 560, 610 orally (Nagao, 1972)
 
Therap-Cat: Antianginal; antihypertensive; antiarrhythmic (class IV).
Keywords: Antianginal; Calcium Channel Blocker; Benzothiazepines.