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CAS No 42597-57-9 , 3-[2-(4-chlorophenoxy)-2-methylpropanoyl]oxypropyl
pyridine-3-carboxylate

  • Name: 3-[2-(4-chlorophenoxy)-2-methylpropanoyl]oxypropyl
    pyridine-3-carboxylate
  • Synonyms: I 612; Cloprane; Ronifibrato [DCIT,Spanish];Ronifibrate; Ronifibratum [Latin]; Ronifibrate [INN];3-[2-(4-chlorophenoxy)-2-methylpropanoyl]oxypropyl
    pyridine-3-carboxylate; Ronifibrate (INN);
  • CAS Registry Number:
  • Flash Point: 257.3°C
  • Boiling Point: 501.8°Cat760mmHg
  • Density: 1.245g/cm3
  • Refractive index: 1.55
  • Flash Point: 257.3°C
  • Molecular Weight: 377.8188
  • InchiKey: AYJVGKWCGIYEAK-UHFFFAOYSA-N
  • InChI: InChI=1S/C19H20ClNO5/c1-19(2,
    26-16-8-6-15(20)7-9-16)18(23)25-12-4-11-24-17(22)14-5-3-10-21-13-14/h3,
    5-10,13H,4,11-12H2,1-2H3
  • Molecular Formula: C19H20ClNO5
  • Molecular Structure:CAS No:42597-57-9 3-[2-(4-chlorophenoxy)-2-methylpropanoyl]oxypropyl<br />pyridine-3-carboxylate

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References of 3-[2-(4-chlorophenoxy)-2-methylpropanoyl]oxypropyl
pyridine-3-carboxylate
Title: Ronifibrate
CAS Registry Number: 42597-57-9
CAS Name: 3-Pyridinecarboxylic acid 3-[2-(4-chlorophenoxy)-2-methyl-1-oxopropoxy]propyl ester
Synonyms: 3-(nicotinoyloxy)propyl p-chlorophenoxyisobutyrate; 3-[a-(p-chlorophenoxy)isobutyryloxy]propyl nicotinate
Manufacturers' Codes: I-612
Trademarks: Cloprane (Luitpold)
Molecular Formula: C19H20ClNO5
Molecular Weight: 377.82
Percent Composition: C 60.40%, H 5.34%, Cl 9.38%, N 3.71%, O 21.17%
Literature References: Diester of clofibric and nicotinic acids, q.q.v. Prepn: Y. Hirata et al., JP Kokai 73 40777 (1973 to Yamanouchi), C.A. 79, 66180w (1973); H. Shindo et al., JP Kokai 74 30377 (1974 to Kowa Pharm.), C.A. 81, 135984s (1974). Clinical trial in hyperdyslipidemia: A. Bucalossi et al., Clin. Ter. 89, 127 (1979). Efficacy and tolerability: G. Buzzelli et al., ibid. 251.
Properties: LD50 orally in mice: 4.08 g/kg (Bucalossi).
Toxicity data: LD50 orally in mice: 4.08 g/kg (Bucalossi)
Therap-Cat: Antilipemic.
Keywords: Antilipemic; Fibrates.