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CAS No 42794-76-3 , 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide

  • Name: 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide
  • Synonyms: Midodrine HCL; Midodrina; ProAmatine;Midodrin; Midodrine [INN:BAN]; Midodrinum [INN-Latin]; Midodrina [INN-Spanish]; Midodrinum;2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide;
  • CAS Registry Number:
  • EINECS: 255-945-3
  • Molecular Weight: 254.28232
  • InchiKey: PTKSEFOSCHHMPD-UHFFFAOYSA-N
  • InChI: InChI=1S/C12H18N2O4/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13/h3-
    5,10,15H,6-7,13H2,1-2H3,(H,14,16)
  • Molecular Formula: C12H18N2O4
  • Molecular Structure:CAS No:42794-76-3 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide

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42794-76-3 Acetamide,2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]-

  • United States HBCChem, Inc. [Manufacturers]
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42794-76-3 Midodrine

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42794-76-3 MIDODRINE

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
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References of 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide
Title: Midodrine
CAS Registry Number: 42794-76-3
CAS Name: 2-Amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide
Synonyms: 1-(2￠,5￠-dimethoxyphenyl)-2-glycinamidoethanol
Molecular Formula: C12H18N2O4
Molecular Weight: 254.28
Percent Composition: C 56.68%, H 7.14%, N 11.02%, O 25.17%
Literature References: a-Adrenergic agonist. Prepn: K. Wismayr et al., AT 241435; eidem, US 3340298 (1965, 1967 both to OSSW). Hemodynamic effects: G. Hitzenberger et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 7, 323 (1973). Pharmacodynamic actions: H. Pittner et al., Arzneim.-Forsch. 26, 2145 (1976). Plasma levels: N. Kolassa et al., Arch. Int. Pharmacodyn. Ther. 238, 96 (1979). Use in ejaculation disorders: D. Jonas et al., Eur. Urol. 5, 184 (1979); in circulatory disorders: H. Sazovsky, H. Pittner, Fortschr. Med. 97, 733 (1979). Synthesis of potential metabolites: T. Kappe, W. Witoszynaky, Arch. Pharm. 308, 339 (1975).
 
Derivative Type: Hydrochloride
CAS Registry Number: 3092-17-9
Manufacturers' Codes: ST-1085
Trademarks: Amatine (Roberts); Gutron (Nycomed); Hipertan (Gramon); Metligine (Taisho); ProAmatine (Roberts)
Molecular Formula: C12H18N2O4.HCl
Molecular Weight: 290.74
Percent Composition: C 49.57%, H 6.59%, N 9.64%, O 22.01%, Cl 12.19%
Properties: Crystals, mp 192-193°.
Melting point: mp 192-193°
 
Therap-Cat: Antihypotensive.
Keywords: a-Adrenergic Agonist; Antihypotensive.