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CAS No 4360-12-7 , ajmaline Search by region : Germany

  • Name: ajmaline
  • Synonyms: ajmaline;-;
  • CAS Registry Number:
  • Transport: 1544
  • Melting Point: 189°C
  • Flash Point: 285.155°C
  • Boiling Point: 519.406°C at 760 mmHg
  • Density: 1.373g/cm3
  • Refractive index: 1.701
  • Safety Statements: 13-45-36
  • Hazard Symbols: Xn
  • Flash Point: 285.155°C
  • EINECS: 224-439-4
  • Molecular Weight: 326.43
  • InChI: InChI=1/C20H26N2O2/c1-3-10-11-8-14-17-20(12-6-4-5-7-13(12)21(17)2)9-15(16(11)18(20)23)22(14)19(10)24/h4-7,10-11,14-19,23-24H,3,8-9H2,1-2H3/t10?,11?,14?,15?,16?,17-,18+,19+,20?/m0/s1
  • Risk Statements: 25-20/21/22
  • Molecular Formula: C20H26N2O2
  • Molecular Structure:CAS No:4360-12-7 ajmaline

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4360-12-7 Ajmaline

  • Ajmaline
  • Germany ABCR GmbH & Co KG [Manufacturer]
  • Tel: +49 721 95061-0
  • Fax: +49 721 95061-80
  • Address: Im Schlehert 10
    76187 Karlsruhe
    Germany null,nullGermany
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4360-12-7 Ajmaline

  • Ajmaline
  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
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References of ajmaline
Title: Ajmaline
CAS Registry Number: 4360-12-7
CAS Name: Ajmalan-17,21-diol
Synonyms: rauwolfine
Trademarks: Aritmina (Altana); Gilurytmal (Solvay); Ritmos (Sanofi-Synthelabo); Tachmalin (AWD)
Molecular Formula: C20H26N2O2
Molecular Weight: 326.43
Percent Composition: C 73.59%, H 8.03%, N 8.58%, O 9.80%
Literature References: From roots of Rauwolfia serpentina (L.) Benth. (Ophioxylon serpentinum L.), Apocynaceae. Isolation: S. Siddiqui, R. H. Siddiqui, J. Indian Chem. Soc. 8, 667 (1931); 9, 539 (1932); 12, 37 (1935); L. van Itallie, A. J. Steenhauer, Arch. Pharm. 270, 313 (1932). Structure: A. Chatterjee, S. Bose, J. Indian Chem. Soc. 31, 17 (1954); F. A. L. Anet et al., J. Chem. Soc. 1954, 1242. Stereochemistry: M. F. Bartlett et al., J. Am. Chem. Soc. 84, 622 (1962). Synthesis: S. Masamune et al., ibid. 89, 2506 (1967); E. E. Van Tamelen, L. K. Oliver, ibid. 92, 2136 (1970); K. Mashimo, Y. Sato, Chem. Pharm. Bull. 18, 353 (1970). Physico-chemical properties: A. Petter, Arzneim.-Forsch. 24, 874 (1974). Antiarrhythmic activity: A. Petter, K. Engelmann, ibid. 876. Reviews: R. Robinson in Festschrift Arthur Stoll (Birkh?user-Verlag, Basel, 1957) pp 457-467; A. Koskinen, M. Lounasmaa in Progress in the Chemistry of Natural Products vol. 43, W. Herz et al., Eds. (Springer-Verlag, New York, 1983) pp 268-346.
Properties: Pale amber, solvated, tetragonal prisms from methanol, C20H26N2O2.CH3OH, mp 158-160°. [a]D18 +131° (c = 0.4 in chloroform). Anhydr mp 205-207°. [a]D20 +144° (c = 0.8 in chloroform). uv max (ethanol): 247, 295 nm (log e 3.94, 3.49). Sol in methanol, ethanol, ether, chloroform; slightly sol in water.
Melting point: mp 158-160°; mp 205-207°
Optical Rotation: [a]D18 +131° (c = 0.4 in chloroform); [a]D20 +144° (c = 0.8 in chloroform)
Absorption maximum: uv max (ethanol): 247, 295 nm (log e 3.94, 3.49)
 
Derivative Type: Hydrochloride dihydrate
Molecular Formula: C20H26N2O2.2HCl.2H2O
Molecular Weight: 435.39
Percent Composition: C 55.17%, H 7.41%, N 6.43%, O 14.70%, Cl 16.29%
Properties: Hexagonal bipyramidal crystals from water, mp 140°. [a]D18 +96.6°. One gram dissolves in 40 ml water.
Melting point: mp 140°
Optical Rotation: [a]D18 +96.6°
 
Therap-Cat: Antihypertensive; antiarrhythmic.
Keywords: Antiarrhythmic; Antihypertensive.