CAS No 467-14-1 , Morphinan-6-ol,8,14-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5a,6a)-

Name: Morphinan-6-ol,8,14-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5a,6a)-
Synonyms: Neopin; Neopine (6CI,7CI);Morphinan-6a-ol, 8,14-didehydro-4,5a-epoxy-3-methoxy-17-methyl-(8CI); b-Codeine;Morphinan-6-ol,8,14-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5a,6a)-;
CAS Registry Number:467-14-1
Flash Point: 238.2°C
Boiling Point: 470.3°C at 760 mmHg
Density: 1.34g/cm³
Refractive index: 1.667
Flash Point: 238.2°C
EINECS: 207-387-7
Molecular Weight: 299.3642
InChI: InChI=1/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3-4,6,12-13,17,20H,5,7-9H2,1-2H3/t12-,13+,17+,18+/m1/s1
Molecular Formula: C18H21 N O3
Molecular Structure:

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467-14-1 (5alpha,6alpha)-8,14-didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol

(5alpha,6alpha)-8,14-didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol
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467-14-1 NEOPINE

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References of Morphinan-6-ol,8,14-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5a,6a)-

Title: Neopine
CAS Registry Number: 467-14-1
CAS Name: (5a,6a)-8,14-Didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol
Synonyms: b-codeine
Molecular Formula: C18H21NO3
Molecular Weight: 299.36
Percent Composition: C 72.22%, H 7.07%, N 4.68%, O 16.03%
Literature References: An alkaloid from opium, isomeric with codeine. Prepn from 14-bromocodeinone: Conroy, US 2797222 (1957 to Merck & Co.); from thebaine: S. Makleit et al., Acta Chim. Acad. Sci. Hung. 94, 161 (1977).
Properties: Long needles from petr ether, mp 127.5°. [a]D23 -28° (c = 7.5 in chloroform). The absorption spectrum seems identical with that of codeine: Dobbie, Lauder, J. Chem. Soc. 99, 34 (1911). Solubilities about the same as those of codeine, q.v.
Melting point: mp 127.5°
Optical Rotation: [a]D23 -28° (c = 7.5 in chloroform)

Derivative Type: Hydrobromide
Molecular Formula: C18H21NO3.HBr
Molecular Weight: 380.28
Percent Composition: C 56.85%, H 5.83%, N 3.68%, O 12.62%, Br 21.01%
Properties: Prismatic crystals from water, darkens about 240°, dec 283°. [a]D23 +17° (c = 3.7). Relatively insol in water, making possible a separation from other more sol hydrobromides of various opium alkaloids.
Optical Rotation: [a]D23 +17° (c = 3.7)

NOTE: Incorrectly called hydroxycodeine, cf. L. J. Sargent, U. Weiss, J. Org. Chem. 25, 987 (1960).