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CAS No 476-32-4 , Chelidonine

  • Name: Chelidonine
  • Synonyms: (+)-Chelidonine; Khelidonin; Chelidonin [German]; CHEBI:31389;Chelidonine; Chelidonin; CHELIDONINE; Helidonine; 476-32-4;Stylophorin;
  • CAS Registry Number:
  • Transport: UN 2811
  • Melting Point: 135-140 ºC
  • Flash Point: 260.7°C
  • Boiling Point: 507.4°C at 760 mmHg
  • Density: 1.422g/cm3
  • Refractive index: 1.667
  • Safety Statements: R20/21/22;R25
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 260.7°C
  • EINECS: 207-504-1
  • Molecular Weight: 353.36856
  • InchiKey: GHKISGDRQRSCII-ZOCIIQOWSA-N
  • InChI: InChI=1S/C20H19NO5/c1-21-7-13-11(2-3-15-20(13)26-9-23-15)18-14(22)4-10-
    5-16-17(25-8-24-16)6-12(10)19(18)21/h2-3,5-6,14,18-19,22H,4,7-9H2,
    1H3/t14-,18-,19+/m0/s1
  • Risk Statements: S20;S36/37;S45
  • Molecular Formula: C20H19NO5
  • Molecular Structure:CAS No:476-32-4 Chelidonine
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476-32-4 Chelidonine

  • Chelidonine Type: Chelidonium Majus Extract Latin Name: Chelidonium majus L Origin: China Part: Whole plant Form: Powder Colour: Brown yellow BSE/TSE: Free Active Ingredient: Chelidonine CAS: 476-32-4 MF: C20H19NO5 MW: 353.37 EINECS: 207-504-1 Assay:...
  • Min. Order: 500
  • China Hubei Saichuang Group [Manufacturer, Trading Company]
  • Tel: 86-027-50756064
  • Address: Zhongshan Road wuhan,HubeiChina
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476-32-4 Gmp factory supplier of Celandine Extract Chelidonine

  • Gmp factory supplier of Celandine Extract Chelidonine Min.Order Quantity: 1 Kilogram/Kilograms Supply Ability: 500 Kilogram/Kilograms per Month Port: DaLian in China Payment Terms: L/C,T/T,Western Union,MoneyGram Specifications 1.Appearance:Brown yel...
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  • China DaXingAnLing Lingonberry Boreal Biotech Co.,Ltd. [Manufacturer]
  • Tel: 86-452-6197119
  • Fax: 86-452-6197939
  • Address: Yongxing Street, Xiaoyangqi Town, Songling District Daxinganling,HeilongjiangChina
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476-32-4 CHELIDONINE

  • Germany ABCR GmbH & Co KG [Manufacturer]
  • Tel: +49 721 95061-0
  • Fax: +49 721 95061-80
  • Address: Im Schlehert 10
    76187 Karlsruhe
    Germany ,Germany
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476-32-4 Chelidonine

  • China Chemrio International Limited [Manufacturer]
  • Tel: +86 574 2789 1268/ +86-139 5789 5864 (mobile)
  • Fax: +86 574 2789 1266
  • Address: Chemrio International Limited
    Room 611-612, Wante Business Center
    No.487 Yangmuqi Road,
    Hi-tech Park Ningbo, 315040,China ,China
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476-32-4 Chelidonine

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476-32-4 Chelidonine

  • China Taiyuan RHF CO., ltd. [Manufacturers]
  • Tel: 0351-7436719
  • Fax: +86-351-7436719
  • Address: Shuangta South Alley 46,2-1, YingZe Area,Taiyuan, ShanXi ,ShanXiChina
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476-32-4 CHELIDONINE

  • Germany Cfm Oskar Tropitzsch [Manufacturer]
  • Tel: +49-9231-9619-0
  • Fax: +49-9231-9619-60
  • Address: Cfm Oskar Tropitzsch
    Waldershofer Str. 49-51
    95615 Marktredwitz
    Germany ,Germany
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476-32-4 CHELIDONINE (+)-(RG)

  • CHELIDONINE (+)-(RG)Stylophorin
  • United States ChromaDex Inc. [Manufacturer]
  • Tel: 949-419-0288
  • Fax: 949-419-0294
  • Address: ChromaDex Inc.
    10005 Muirlands Blvd. Suite G - First Floor
    Irvine, CA 92618 ,United States
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476-32-4 CHELIDONIN HPLC GRADE

  • Germany AppliChem GmbH [Manufacturer]
  • Tel: +49 6151 93 57 0
  • Fax: +49 6151 93 57 11
  • Address: AppliChem GmbH
    Ottoweg 4
    64291 Darmstadt
    Germany ,Germany
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476-32-4 Chelidonine

  • Synonyms Chelidonine CAS RN 476-32-4 Formula C20H19NO5 Molecular Weight 353.37 Melting Point 212-213centigrade Resource Chelidonium majus Package 20mg,100mg or more Storage Store below 25centigrade and keep away from moisture and light.
  • China Nanjing Spring&Autumn Biological Engineering Co., Ltd. [Manufacturer, Distributor/Wholesaler]
  • Tel: 86-25-84430028
  • Address: Room 805, No. 2, Sheng Li Cun Road, Xuanwu District, Nanjing(Xiao-Wei Street, Nanjing Jinling Biomedical Science and Technology Industrial Park) Nanjing,JiangsuChina
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References of Chelidonine
Title: Chelidonine
Synonyms: Stylophorin
Molecular Formula: C20H19NO5
Molecular Weight: 353.37
Percent Composition: C 67.98%, H 5.42%, N 3.96%, O 22.64%
Literature References: Hexahydrobenzophenanthridine alkaloid. Occurs in nature in (+)-form, (-)-form and racemic form. Isoln of (+)-form from root of Chelidonium majus L., Stylophorum diphyllum (Michx.) Nutt., and Dicranostigma franchetianum (Prain) Fedde, Papaveraceae: J. M. Probst, Ann. 29, 113 (1839); E. Schmidt, F. Selle, Arch. Pharm. 228, 441 (1890); F. Selle, ibid. 96; Manske, Can. J. Res. 20B, 53 (1942); J. Slavik, Collect. Czech. Chem. Commun. 20, 198 (1955); from Symphoricarpos albus L., Blake, Caprifoliaceae: M. Szaufer et al., Phytochemistry 17, 1446 (1978). Isoln of (-)-form from Glaucium corniculatum Curt., Papaveraceae: J. Slavik, L. Slavikova, Collect. Czech. Chem. Commun. 22, 279 (1957). Structure: F. von Bruchhausen, H. W. Bersch, Ber. 63, 2520 (1930); E. Sp?th, F. Kuffner, ibid. 64, 370 (1931); H. W. Bersch, Arch. Pharm. 291, 491 (1958). Identity of (±)-form with diphylline: J. Slavik, Collect. Czech. Chem. Commun. 26, 2933 (1961). Absolute configuration of (+)-p-bromobenzoate: N. Takao et al., Tetrahedron Lett. 1979, 495. Conformation: M. Cushman, T.-C. Choong, Heterocycles 14, 1935 (1980); M. Sugiura et al., J. Chem. Soc. Perkin Trans. 2 1986, 175. Chiroptic properties and absolute configuration of (+)-chelidonine: N. Takao et al., Arch. Pharm. 317, 223 (1984). Biosynthesis: E. Leete, J. Am. Chem. Soc. 85, 473 (1963). Total synthesis of (±)-form: W. Oppolzer, K. Keller, ibid. 93, 3836 (1971); M. Cushman et al., J. Org. Chem. 45, 5067 (1980); W. Oppolzer, C. Rabbiani, Helv. Chim. Acta 66, 1119 (1983); M. Hanaoka et al., Chem. Lett. 1986, 736. Effect on smooth muscle: P. J. Hanzlik: J. Pharmacol. Exp. Ther. 7, 99 (1915). Inhibition of reverse transcriptase activity: M. L. Sethi, Can. J. Pharm. Sci. 16, 29 (1981). Cytotoxic effects: M. Cushman et al., loc. cit. Review of pharmacological effects: V. Preininger, "The Biology of Papaveraceae Alkaloids" in The Alkaloids vol. 15, R. H. F. Manske, Ed. (Academic Press, Orlando, 1975) pp 241-242. General review: V. Simanek, "Benzophenanthridine Alkaloids" ibid. vol. 26, A. Brossi, Ed. (1985) pp 185-240. Toxicity data: R. C. Anderson, K. K. Chen, Fed. Proc. 5, 163 (1946).
 
Derivative Type: (+)-Form
CAS Registry Number: 476-32-4
Synonyms: [5bR-(5ba,6b,12ba)]-5b,6,7,12b,13,14-Hexahydro-13-methyl[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridin-6-ol
Properties: Monoclinic prisms from methanol, ethanol or ethanol + chloroform, mp 135-136°. bp0.002 220° (air-bath temp). [a]D22 +115 ±3° (ethanol); [a]D20 +117° (c = 3 in CHCl3). uv max (methanol): 289, 239, 208 nm (log e 3.89, 3.88, 4.69). Sol in alc, chloroform, ether, amyl alc. Practically insol in water. LD50 in mice (mg/kg): 34.6 ±2.44 i.v. (Anderson, Chen).
Melting point: mp 135-136°
Boiling point: bp0.002 220° (air-bath temp)
Optical Rotation: [a]D22 +115 ±3° (ethanol); [a]D20 +117° (c = 3 in CHCl3)
Absorption maximum: uv max (methanol): 289, 239, 208 nm (log e 3.89, 3.88, 4.69)
Toxicity data: LD50 in mice (mg/kg): 34.6 ±2.44 i.v. (Anderson, Chen)
 
Derivative Type: (+)-O-Acetylchelidonine
Molecular Formula: C22H21NO6
Molecular Weight: 395.41
Percent Composition: C 66.83%, H 5.35%, N 3.54%, O 24.28%
Properties: Crystals from chloroform, mp 184-186°. [a]D +110°.
Melting point: mp 184-186°
Optical Rotation: [a]D +110°
 
Derivative Type: (+)-Benzoylchelidonine
Molecular Formula: C27H23NO6
Molecular Weight: 457.47
Percent Composition: C 70.89%, H 5.07%, N 3.06%, O 20.98%
Properties: Crystals from chloroform, mp 210-211°.
Melting point: mp 210-211°
 
Derivative Type: (-)-Form
CAS Registry Number: 88200-01-5
Properties: Crystals from aqueous ethanol, mp 136°. [a]D22 -112 ±3° (c = 0.47 in ethanol).
Melting point: mp 136°
Optical Rotation: [a]D22 -112 ±3° (c = 0.47 in ethanol)
 
Derivative Type: (±)-Form
CAS Registry Number: 20267-87-2
Synonyms: Diphylline
Properties: Crystals from ethanol, mp 215-216°.
Melting point: mp 215-216°