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CAS No 484-23-1 , (4-hydrazinylphthalazin-1-yl)hydrazine

  • Name: (4-hydrazinylphthalazin-1-yl)hydrazine
  • Synonyms: Ophthazin; Dihydrallazine; Nepresol; 1,4-Dihydrazinophthalazine; Dihydralazin;Dihydrallazin; Hypopresol; Nepresolin;(4-hydrazinylphthalazin-1-yl)hydrazine;
  • CAS Registry Number:
  • Melting Point: 180ºC
  • Density: 1.543 g/cm3
  • Refractive index: 1.899
  • Safety Statements: Poison by intravenous route. An experimental teratogen. When heated to decomposition it emits toxic fumes of NOx.
  • EINECS: 207-605-0
  • Molecular Weight: 190.2052
  • InchiKey: VQKLRVZQQYVIJW-UHFFFAOYSA-N
  • InChI: InChI=1S/C8H10N6/c9-11-7-5-3-1-2-4-6(5)8(12-10)14-13-7/h1-4H,9-10H2,(H,
    11,13)(H,12,14)
  • Molecular Formula: C8H10N6
  • Molecular Structure:CAS No:484-23-1 (4-hydrazinylphthalazin-1-yl)hydrazine

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484-23-1 Dihydralazine

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484-23-1 Dihydralazine

  • China Facus Pharmaceutical Co., Ltd. [Manufacturers]
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484-23-1 Dihydralazine

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484-23-1 Ophthazin

  • China Shanghai Luer Chemical Trading Co., Ltd [Importer/Exporter]
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484-23-1 OPHTHAZIN

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
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  • Address: Rm.902 Longyin Plaza,
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References of (4-hydrazinylphthalazin-1-yl)hydrazine
Title: Dihydralazine
CAS Registry Number: 484-23-1
CAS Name: 2,3-Dihydro-1,4-phthalazinedione dihydrazone
Synonyms: 1,4-dihydrazinophthalazine
Molecular Formula: C8H10N6
Molecular Weight: 190.21
Percent Composition: C 50.52%, H 5.30%, N 44.18%
Literature References: Vasodilator. Prepn: J. Druey, US 2484785 (1949 to Ciba); J. Druey, B. H. Ringier, Helv. Chim. Acta 34, 195 (1951); Zerweck, Kunze, US 2786839 (1957 to Cassella Farbw.). Pharmacology: P. A. Van Zwieten, Arzneim.-Forsch. 18, 79 (1968). Mechanism of action: I. W. Reimann et al., Clin. Sci. 61, 319s (1981); eidem, Clin. Exp. Pharmacol. Physiol. 12, 79 (1985). Cerebrovascular effects in rats: L. M. Auer et al., Acta Med. Scand. Suppl. 678, 73 (1983); D. I. Barry et al., Stroke 15, 102 (1984). Hemodynamic responses in man: G. G. Belz, Clin. Pharmacol. Ther. 37, 48 (1985). Clinical studies: A. Salvadeo et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 19, 372 (1981); P. I. Salmela et al., Ann. Clin. Res. 13, 433 (1981). Toxicity data: G. Steiner et al., J. Med. Chem. 24, 59 (1981).
Properties: Orange needles from water, dec about 180°. LD50 i.p. in rats: 1084 mmol/kg (Steiner).
Toxicity data: LD50 i.p. in rats: 1084 mmol/kg (Steiner)
 
Derivative Type: Sulfate
CAS Registry Number: 7327-87-9
Trademarks: Pressunic (Unipharm)
Molecular Formula: C8H10N6.H2SO4
Molecular Weight: 288.28
Percent Composition: C 33.33%, H 4.20%, N 29.15%, S 11.12%, O 22.20%
Properties: Needles, dec 233°.
 
Derivative Type: Sulfate hemipentahydrate
Trademarks: Depressan (OPW); Dihyzin (Henning); Nepresol (Novartis); Népressol (Novartis)
 
Derivative Type: Methanesulfonate
Synonyms: Dihydralazine mesylate
Trademarks: Nepresol Inject (Novartis)
Molecular Formula: C8H10N6.CH3SO3H
Molecular Weight: 286.31
Percent Composition: C 37.75%, H 4.93%, N 29.35%, S 11.20%, O 16.76%
 
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive; Hydrazines/Phthalazines.