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CAS No 49697-38-3 , Rimexolone

  • Name: Rimexolone
  • Synonyms: (11b,16a,17b)-11-Hydroxy-16,17-dimethyl-17-(1-oxopropyl)androsta-1,4-dien-3-one;Rimexolone;
  • CAS Registry Number:
  • Flash Point: 163.314°C
  • Boiling Point: 490.23°C at 760 mmHg
  • Density: 1.12
  • Refractive index: 1.561
  • Flash Point: 163.314°C
  • Molecular Weight: 370.52
  • InChI: InChI=1/C23H32O4/c1-13-10-17-16-7-6-14-11-15(24)8-9-21(14,2)19(16)18(25)12-22(17,3)23(13,4)20(26)27-5/h8-9,11,13,16-19,25H,6-7,10,12H2,1-5H3/t13-,16+,17+,18+,19-,21+,22+,23-/m1/s1
  • Molecular Formula: C24H34O3
  • Molecular Structure:CAS No:49697-38-3 Rimexolone

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49697-38-3 Rimexolone

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49697-38-3 Rimexolone

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49697-38-3 Rimexolone

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References of Rimexolone
Title: Rimexolone
CAS Registry Number: 49697-38-3
CAS Name: (11b,16a,17b)-11-Hydroxy-16,17-dimethyl-17-(1-oxopropyl)androsta-1,4-dien-3-one
Synonyms: 11b-hydroxy-16a,17a-dimethyl-17-propionylandrosta-1,4-dien-3-one; 11b-hydroxy-16a,17a,21-trimethylpregna-1,4-diene-3,20-dione; trimexolone
Manufacturers' Codes: Org-6216
Trademarks: Rimexel (Organon); Vexol (Alcon)
Molecular Formula: C24H34O3
Molecular Weight: 370.52
Percent Composition: C 77.80%, H 9.25%, O 12.95%
Literature References: Prepn: NL 7300313; G. F. Woods et al., US 3947478 (1973, 1976 both to Akzo); J. Cairns et al., J. Chem. Soc. Perkin Trans. 1 1981, 2306. Pharmacology: P. K. Fox et al., Arzneim.-Forsch. 30, 55 (1980). Clinical trial in rheumatoid arthritis: E. van Vliet-Daskalopoulou et al., Br. J. Rheumatol. 26, 450 (1987). Clinical pharmacokinetics: G. Gevers et al., Clin. Rheumatol. 13, 103 (1994).
Properties: Crystals, mp 258-268°. [a]D +100° (c = 0.92 in pyridine). uv max: 244 nm (e 14600).
Melting point: mp 258-268°
Optical Rotation: [a]D +100° (c = 0.92 in pyridine)
Absorption maximum: uv max: 244 nm (e 14600)
Therap-Cat: Anti-inflammatory (local).
Keywords: Glucocorticoid.