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CAS No 5072-26-4 , 2-amino-4-(butylsulfonimidoyl)butanoic acid

  • Name: 2-amino-4-(butylsulfonimidoyl)butanoic acid
  • Synonyms: Buthionine sulfoxamine; Buthionine sulphoximine;2-amino-4-(butylsulfonimidoyl)butanoic acid; Butionine sulfoximine; Buthione sulfoximine; Buthionine-S,R-sulfoximine; 5072-26-4;
  • CAS Registry Number:
  • Melting Point: 215 °C (dec.)(lit.)
  • Flash Point: 185°C
  • Boiling Point: 382.3°Cat760mmHg
  • Density: 1.29g/cm3
  • Refractive index: 1.537
  • Safety Statements: S26S36
  • Hazard Symbols: Xi
  • Flash Point: 185°C
  • EINECS: 246-685-1
  • Molecular Weight: 222.30512
  • InchiKey: KJQFBVYMGADDTQ-UHFFFAOYSA-N
  • InChI: InChI=1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,
    1H3,(H,11,12)
  • Risk Statements: 36/37/38
  • Molecular Formula: C8H18N2O3S
  • Molecular Structure:CAS No:5072-26-4 2-amino-4-(butylsulfonimidoyl)butanoic acid

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5072-26-4 DL-BUTHIONINE(S,R)-SULFOXIMINE; 99%

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References of 2-amino-4-(butylsulfonimidoyl)butanoic acid
Title: Buthionine Sulfoximine
CAS Registry Number: 5072-26-4
CAS Name: 2-Amino-4-(S-butylsulfonimidoyl)butanoic acid
Synonyms: S-(3-amino-3-carboxypropyl)-S-butylsulfoximine; S-(n-butyl)homocysteine sulfoximine; BSO
Molecular Formula: C8H18N2O3S
Molecular Weight: 222.31
Percent Composition: C 43.22%, H 8.16%, N 12.60%, O 21.59%, S 14.42%
Literature References: Selective inhibitor of g-glutamyl cysteine synthetase, an enzyme in the glutathione, q.v., biosynthetic pathway. BSO-mediated depletion of intracellular glutathione has been associated with increased sensitivity of tumor cells to antineoplastic agents. Prepn: K. Hayashi, Chem. Pharm. Bull. 8, 177 (1960). Synthesis and in vitro and in vivo enzyme inhibition: O. W. Griffith, A. Meister, J. Biol. Chem. 254, 7758 (1979). Mechanism of action and metabolism in animals O. W. Griffith, ibid. 257, 13704 (1982). Chemosensitization by BSO of melphalan-resistant murine leukemia cells in vivo: S. Somfai-Relle et al., Biochem. Pharmacol. 33, 485 (1984); R. A. Kramer et al., Cancer Res. 47, 1593 (1987). Enhanced melphalan, q.v., cytotoxicity in human cancer cells in vitro: J. A. Green et al., ibid. 44, 5427 (1984); and in mice bearing human tumor xenografts: H. S. Friedman et al., J. Natl. Cancer Inst. 81, 524 (1989).
Properties: Crystals from aq ethanol, mp 214-215.5° (dec). Sol in water. Partition coefficient (octanol/water): 4.34 ±0.0004.
Melting point: mp 214-215.5° (dec)
Log P: Partition coefficient (octanol/water): 4.34 ±0.0004
Use: Biological tool for depletion of glutathione.