Home > Name List By other > (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3, 5-diiodophenyl]propanoic acid

CAS No 51-48-9 , (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,
5-diiodophenyl]propanoic acid

  • Name: (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,
    5-diiodophenyl]propanoic acid
  • Synonyms: Thyrax; Tetraiodothyronine;L-thyroxine; Thyreoideum; Thyroxinal; synthroid; Thyroxine iodine; Thyratabs; levothyroxine;(2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,
    5-diiodophenyl]propanoic acid; thyroxin;
  • CAS Registry Number:
  • Melting Point: 223 ºC (DEC.)
  • Flash Point: 302.3°C
  • Boiling Point: 576.3°Cat760mmHg
  • Density: 2.635g/cm3
  • Refractive index: 1.795
  • Alpha: -5 º (1N NAOH:ETOH 1:2)
  • Safety Statements: R20/21/22:Harmfulbyinhalation,incontactwithskinandifswallowed.;
  • Hazard Symbols: Xn:Harmful;
  • Flash Point: 302.3°C
  • EINECS: 200-101-1
  • Molecular Weight: 776.87002
  • InchiKey: XUIIKFGFIJCVMT-LBPRGKRZSA-N
  • InChI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)
    19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1
  • Risk Statements: S24/25
  • Molecular Formula: C15H11I4NO4
  • Molecular Structure:CAS No:51-48-9 (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,<br />5-diiodophenyl]propanoic acid
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51-48-9 L-Thyroxine 51-48-9 99 %

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  • Steroids powder L-Thyroxine Synonyms: levothyroxine; l-t4; t4(hormone); o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-l-tyrosin; o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine; tetraiodothyronine CAS: 51-48-9 EINECS: 200-101-1 Assay: 99% min. USP30 Pa...
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    • Synonyms: levothyroxine; l-t4; t4(hormone); o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-l-tyrosin; o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine; tetraiodothyronine CAS: 51-48-9 EINECS: 200-101-1 Assay: 99% min. USP30 Packing: 1 kg /foil bag or tin...
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    51-48-9 L-Thyroxine CAS 51-48-9

    • L-Thyroxine Synonyms: levothyroxine; l-t4; t4(hormone); o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-l-tyrosin; o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine; tetraiodothyronine CAS: 51-48-9 EINECS: 200-101-1 Assay: 99% min. USP30 Packing: 1 kg /foi...
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    51-48-9 L-Thyroxine

    • Synonyms: levothyroxine; l-t4; t4(hormone); o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-l-tyrosin; o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine; tetraiodothyronine CAS: 51-48-9 EINECS: 200-101-1 Assay: 99% min. USP30 Packing: 1 kg /foil bag or tin...
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    51-48-9 L-Thyroxine (Steroids)

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    References of (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,
    5-diiodophenyl]propanoic acid
    Title: Thyroxine
    CAS Registry Number: 51-48-9
    CAS Name: O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine
    Synonyms: (-)-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]alanine; 3,5,3¢,5¢-tetraiodo-L-thyronine; levothyroxine; T4
    Molecular Formula: C15H11I4NO4
    Molecular Weight: 776.87
    Percent Composition: C 23.19%, H 1.43%, I 65.34%, N 1.80%, O 8.24%
    Literature References: One of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone, TSH, q.v. Circulates in the serum bound to specific proteins, primarily thyroxine-binding globulin, transthyretin, and albumin. Deiodinated in peripheral tissues to the active metabolite, liothyronine, q.v. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia. Isoln from thyroid: E. C. Kendall, J. Am. Med. Assoc. 64, 2042 (1915); idem, J. Biol. Chem. 39, 125 (1919). Structure: C. R. Harington, Biochem. J. 20, 293, 300 (1926). Synthesis: C. R. Harington, G. Barger, ibid. 21, 169 (1927); of naturally occurring L-form: J. R. Chalmers et al., J. Chem. Soc. 1949, 3424; of isomers and racemate: L. G. Ginger, P. Z. Anthony, US 2889363; US 2889364 (both 1959 to Baxter Labs.). Direct determn in serum by RIA: J. C. Nelson, R. T. Tomel, Clin. Chem. 34, 1737 (1988). Comprehensive description of levothyroxine sodium: A. Post, R. J. Warren, Anal. Profiles Drug Subs. 5, 225-281 (1976). Review of pharmacology: E. Sypniewski, Ann. Thorac. Surg. 56, S2-S8 (1993); of therapeutic use: A. D. Toft, N. Engl. J. Med. 331, 174-180 (1994). Review of thyroid physiology: D. A. Fisher, Clin. Chem. 42, 135-139 (1996); R. R. Cavalieri, Thyroid 7, 177-181 (1997).
    Properties: Crystals, dec 235-236°. [a]25546 -3.2° (0.66 g in 6.07 g of 0.5N NaOH and 13.03 g alc); [a]D20 -4.4° (3% in 0.13N NaOH in 70% EtOH).
    Optical Rotation: [a]25546 -3.2° (0.66 g in 6.07 g of 0.5N NaOH and 13.03 g alc); [a]D20 -4.4° (3% in 0.13N NaOH in 70% EtOH)
     
    Derivative Type: Sodium salt
    CAS Registry Number: 55-03-8
    Synonyms: Levothyroxine sodium
    Trademarks: Eferox (Wyeth); Eltroxin (GSK); Euthyrox (Merck KGaA); Levaxin (Nycomed); Levothroid (Forest); Levothyrox (Merck-Cl¢enot); Levoxyl (Jones); Oroxine (GSK); Soloxine (Virbac); Synthroid (Knoll); Thyro-Tabs (VET A MIX)
    Molecular Formula: C15H10I4NNaO4
    Molecular Weight: 798.85
    Percent Composition: C 22.55%, H 1.26%, I 63.54%, N 1.75%, Na 2.88%, O 8.01%
    Properties: Occurs as the hydrate. Triclinic crystals or cream-colored powder. Odorless, tasteless, somewhat hygroscopic. d420 2.381. [a]D20 -4.4° (c = 3 in 70% ethanol). Soly in water (25°): about 15 mg/100 ml. Sol in mineral acids and in solns of alkali hydroxides and carbonates. More sol in alcohol. Very slightly sol in chloroform, ether. pH of a satd water soln: 8.35 to 9.35.
    Optical Rotation: [a]D20 -4.4° (c = 3 in 70% ethanol)
    Density: d420 2.381
     
    Derivative Type: DL-Thyroxine
    CAS Registry Number: 300-30-1
    Properties: Needle-like crystals. Dec 231-233°. Insol in water, in alcohol, and in the other usual organic solvents, but in the presence of mineral acids or alkalies it dissolves in alcohol; sol in solns of the alkali hydroxides and in hot solns of the alkali carbonates.
     
    Derivative Type: D-Thyroxine
    CAS Registry Number: 51-49-0
    Synonyms: Dextrothyroxine
    Properties: Crystals, dec 237°. [a]21546 +2.97° (0.74 g in 6 g of 0.5N NaOH and 14 g of alcohol).
    Optical Rotation: [a]21546 +2.97° (0.74 g in 6 g of 0.5N NaOH and 14 g of alcohol)
     
    Derivative Type: D-Thyroxine sodium salt
    CAS Registry Number: 137-53-1
    Synonyms: Dextrothyroxine sodium
    Trademarks: Choloxin (Knoll); Debetrol (Sanofi); Dethyrona (Abbott); Dextroid (Baxter); Dynothel (Henning); Eulipos (Boehringer, Mann.)
     
    Therap-Cat: Thyroid hormone. Dextrothyroxine as antilipemic.
    Therap-Cat-Vet: Thyroid hormone.
    Keywords: Antihypothyroid; Thyroid Hormone.