Home > Name List By other > (6S,8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,10,13-trimethyl-2,6,7, 8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenant...

CAS No 520-85-4 , (6S,8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,10,13-trimethyl-2,6,7,
8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one

  • Name: (6S,8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,10,13-trimethyl-2,6,7,
    8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
  • Synonyms: Hydroxymethylprogesterone;(6S,8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,10,13-trimethyl-2,6,7,
    8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one; Asconale;Medroxyprogesteron; Medroxiprogesteronum; Medroxyprogesteronum; Medroxiprogesterona; Farlutal;
  • CAS Registry Number:
  • Melting Point: 220-223.5 DEG C
  • Flash Point: 263°C
  • Boiling Point: 488°Cat760mmHg
  • Density: 1.13g/cm3
  • Refractive index: 1.538
  • Safety Statements: An experimental teratogen. Experimental reproductive effects. A steroid. When heated to decomposition it emits acrid smoke and irritating fumes.
  • Hazard Symbols: Xn
  • Flash Point: 263°C
  • EINECS: 208-298-6
  • Molecular Weight: 344.48768
  • InchiKey: FRQMUZJSZHZSGN-HBNHAYAOSA-N
  • InChI: InChI=1S/C22H32O3/c1-13-11-16-17(20(3)8-5-15(24)12-19(13)20)6-9-21(4)18
    (16)7-10-22(21,25)14(2)23/h12-13,16-18,25H,5-11H2,1-4H3/t13-,16+,17-,
    18-,20+,21-,22-/m0/s1
  • Risk Statements: 48-63-68
  • Molecular Formula: C22H32O3
  • Molecular Structure:CAS No:520-85-4 (6S,8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,10,13-trimethyl-2,6,7,<br />8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one

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520-85-4 Medroxyprogesterone

  • IUPAC NAME-(6α)-17-hydroxy-6-methylpregn-4-ene-3,20-dione MOLECULAR FORMULA-C22H32O3 MOLAR MASS-344.488 g/mol MP itself is not used clinically, though it has seen limited use in veterinary medicine under the trade name Controlestril in France. In ad...
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520-85-4 Pregn-4-ene-3,20-dione,17-hydroxy-6-methyl-, (6a)-

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520-85-4 Medroxyprogesterone

  • United States LGM Pharma [Manufacturer]
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520-85-4 Medroxyprogesterone

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520-85-4 Medroxyprogesterone USP

  • China AFINE CHEMICALS LIMITED [Manufacturer]
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520-85-4 Medroxyprogesterone

  • China CIDIC Co.,Ltd. []
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520-85-4 Pregn-4-ene-3,20-dione,17-hydroxy-6-methyl-, (6a)-

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520-85-4 Medroxyprogesterone

  • China N-Techem International Co.Ltd. []
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520-85-4 Medroxyprogesterone

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520-85-4 Medroxyprogesterone

  • China Unitechem CO., Ltd []
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References of (6S,8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,10,13-trimethyl-2,6,7,
8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
Title: Medroxyprogesterone
CAS Registry Number: 520-85-4
CAS Name: (6a)-17-Hydroxy-6-methylpregn-4-ene-3,20-dione
Synonyms: 17a-hydroxy-6a-methylprogesterone; 6a-methyl-17a-hydroxyprogesterone; 6a-methyl-4-pregnen-17a-ol-3,20-dione
Molecular Formula: C22H32O3
Molecular Weight: 344.49
Percent Composition: C 76.70%, H 9.36%, O 13.93%
Literature References: Orally active progestogen; formerly used in combinations as oral contraceptive. Prepn: J. C. Babcock et al., J. Am. Chem. Soc. 80, 2904 (1958); GB 866381; G. B. Spero, US 3377364 (1961, 1968 both to Upjohn); P. Ruggieri, C. Ferrari, US 3043832 (1962 to Ormonoterapia Richter); B. Camerino et al., US 3061616 (1962 to Farmitalia). HPLC determn in plasma: J. Read, G. Mould, J. Chromatogr. 341, 437 (1985). Comparative clinical trial with norethisterone as injectable contraceptive: H. K. Toppozada et al., Contraception 28, 1 (1983). Clinical trial in advanced breast cancer: M. Izuo et al., Cancer 56, 2576 (1985). Review of pharmacology and clinical uses: I. S. Fraser, E. Weisberg, Med. J. Aust. 1, Suppl. 1, 3-19 (1981).
Properties: Crystals from chloroform, mp 220-223.5°. [a]D25 +75° (in chloroform). uv max (ethanol): 241 nm (e 16000).
Melting point: mp 220-223.5°
Optical Rotation: [a]D25 +75° (in chloroform)
Absorption maximum: uv max (ethanol): 241 nm (e 16000)
 
Derivative Type: 17-Acetate
CAS Registry Number: 71-58-9
Synonyms: 17a-Acetoxy-6a-methylprogesterone; 6-a-methyl-17a-acetoxyprogesterone; MAP
Trademarks: Amen (Elan); Clinovir (Pharmacia); Cycrin (Wyeth); Depo-Clinovir (Pharmacia); Depo-Prodasone (Pfizer); Depo-Provera (Pharmacia & Upjohn); Farlutal (Pharmacia); Gestoral (Novartis); Hysron (Kyowa); Oragest (Pharmagyn); Perlutex (Leo Pharm); Provera (Pharmacia & Upjohn); Veramix (Pharmacia)
Molecular Formula: C24H34O4
Molecular Weight: 386.52
Percent Composition: C 74.58%, H 8.87%, O 16.56%
Properties: Crystals from methanol, mp 207-209°. [a]D +61° (in chloroform). uv max (ethanol): 240 nm (e 15900). Freely sol in chloroform; sol in acetone, dioxane; sparingly sol in ethanol, methanol; slightly sol in ether. Insol in water.
Melting point: mp 207-209°
Optical Rotation: [a]D +61° (in chloroform)
Absorption maximum: uv max (ethanol): 240 nm (e 15900)
 
Therap-Cat: Progestogen; contraceptive (injectable); antineoplastic (hormonal).
Therap-Cat-Vet: Progestogen; estrus regulator.
Keywords: Antineoplastic (Hormonal); Progestogens; Contraceptive (Injectable); Progestogen.