Home > Name List By 2 > 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

CAS No 53-86-1 , 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

  • Name: 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
  • Synonyms: Amuno;indometacin; Tannex; Imbrilon; Metindol;2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid; Indocid; Indocin; Indomethacine; Indomethacinum;
  • CAS Registry Number:
  • Transport: UN 2811
  • Melting Point: 155-162 ºC
  • Flash Point: 255.8 °C
  • Boiling Point: 499.4 °C at 760 mmHg
  • Density: 1.32g/cm3
  • Water Solubility: Insoluble
  • Safety Statements: R28
  • Hazard Symbols: T+: Very toxic;
  • Flash Point: 255.8 °C
  • EINECS: 200-186-5
  • Molecular Weight: 357.78764
  • InchiKey: CGIGDMFJXJATDK-UHFFFAOYSA-N
  • InChI: InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)
    19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
  • Risk Statements: S28;S36/37;S45
  • Molecular Formula: C19H16ClNO4
  • Molecular Structure:CAS No:53-86-1 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
Search by region :

Select to

53-86-1 Indomethacin

  • CAT NO:MC20843,chemical name:Indomethacin,CAS NO:53-86-1,Purity:98%,MF:C17H19N3,MW:265.35,Link:http://www.molcore.com/product/53-86-1.html
  • China Hangzhou molcore Biopharmatech Co., Ltd [Manufacturer, Trading Company]
  • Tel: 86--17767106207
  • Fax: --
  • Address: Joinhands Sci Park No.4028 Nanhuan RD Hangzhou,China. Hangzhou,ZhejiangChina
Contact Supplier

53-86-1 Indometacin

  • Indometacin Product name: Indometacin Other name: indomethacin methanol solution; indomethacin crystalline; indomethacin usp; indometacin;INDOMETHACINE CAS No.: 53-86-1 Assay: 98.5-100.5% Packing: 25kg/drum M.F.: C19H16ClNO4 M.W.: 357.79 Appearance: ...
  • China Hubei Yuancheng Pharmaceutical Co., Ltd [Manufacturer]
  • Tel: 086-027-50756084
  • Fax: --
  • Address: Zhongshan Road Wuhan,HubeiChina
Contact Supplier

53-86-1 Indometacin

  • Product Name: Indometacin Synonyms: AURORA KA-6542;INDOCIN;INDOMETACIN;INDOMETACINE;INDOMETHACIN;INDOMETHACINE;LABOTEST-BB LT00244830;1-(P-CHLOROBENZYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID CAS: 53-86-1 MF: C19H16ClNO4 MW: 357.79 EINECS: 200-186-5 ...
  • Min. Order: 500
  • FOB Price: USDfalse - false /
  • China Wuhan Hezhong Bio-Chemical Manufature Co.,Ltd [Manufacturer]
  • Tel: 86-27-50756046
  • Address: Zhongshan Road No 496 Wuhan,HubeiChina
Contact Supplier

53-86-1 Indometacin 53-86-1

  • Indometacin 53-86-1 Synonyms: AURORA KA-6542;INDOCIN;INDOMETACIN;INDOMETACINE;INDOMETHACIN;INDOMETHACINE;LABOTEST-BB LT00244830;1-(P-CHLOROBENZYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID CAS: 53-86-1 MF: C19H16ClNO4 MW: 357.79 EINECS: 200-186-5 Produc...
  • China Hubei Yuancheng Saichuang Technology Co.Ltd [Manufacturer]
  • Tel: 86-027-50756140
  • Address: Zhongshan Road Wuhan,HubeiChina
Contact Supplier

53-86-1 Indometacin

  • Product Name: Indometacin Synonyms: AURORA KA-6542;INDOCIN;INDOMETACIN;INDOMETACINE;INDOMETHACIN;INDOMETHACINE;LABOTEST-BB LT00244830;1-(P-CHLOROBENZYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID CAS: 53-86-1 MF: C19H16ClNO4 MW: 357.79 EINECS: 200-186-5 ...
  • China Hubei Yuancheng Saichuang Technology Co.Ltd [Manufacturer]
  • Tel: 86-027-50756140
  • Address: Zhongshan Wuhan,HubeiChina
Contact Supplier

53-86-1 China Factory Price Indometacin

  • Basic Info Name:Indometacin Apearance:White Powder CAS:53-86-1 MF:C19H16ClNO4 MW:357.79 Shipment:Air/Sea/EMS,DHL,TNT,UPS,Fedx Package:25kg/Cardboard Barrel Payment: Bank Transfer,Bitcoin,WU,MoneyGram Trademark:YuanChen Origin:China Price:fluctuated E...
  • Min. Order: 1000
  • China Yuan Chen Co. Ltd [Manufacturer]
  • Tel: 86-027-50756092
  • Address: 496 Zhongshan Road Wuhan,HubeiChina
Contact Supplier

53-86-1 China Factory Price Indometacin

  • Basic Info Name:Indometacin Apearance:White Powder CAS:53-86-1 MF:C19H16ClNO4 MW:357.79 Shipment:Air/Sea/EMS,DHL,TNT,UPS,Fedx Package:25kg/Cardboard Barrel Payment: Bank Transfer,Bitcoin,WU,MoneyGram Trademark:YuanChen Origin:China Price:fluctuated E...
  • Min. Order: 1000
  • China YuanChne Co. Ltd [Manufacturer]
  • Tel: 86-027-50756092
  • Address: 496 Zhongshan Road Wuhan,HubeiChina
Contact Supplier

53-86-1 China Factory Price Indometacin

  • Basic Info Name:Indometacin Apearance:White Powder CAS:53-86-1 MF:C19H16ClNO4 MW:357.79 Shipment:Air/Sea/EMS,DHL,TNT,UPS,Fedx Package:25kg/Cardboard Barrel Payment: Bank Transfer,Bitcoin,WU,MoneyGram Trademark:YuanChen Origin:China Price:fluctuated E...
  • Min. Order: 1000
  • China YuanChen Co. Ltd [Manufacturer]
  • Tel: 86-5075-6092
  • Address: 496 ZhongShan Road Wuhan,China
Contact Supplier

53-86-1 Indometacin Skype bran at ycphar dot com

  • Basic Info Name:Indometacin Apearance:White Powder CAS:53-86-1 MF:C19H16ClNO4 MW:357.79 Shipment:Air/Sea/EMS,DHL,TNT,UPS,Fedx Package:25kg/Cardboard Barrel Payment: Bank Transfer,Bitcoin,WU,MoneyGram Trademark:YuanChen Origin:China Price:fluctuated E...
  • Min. Order: 1000
  • China YuanChen Co. Ltd [Manufacturer]
  • Tel: 86-5075-6206
  • Fax: --
  • Address: 496 ZhongShan Road. Wuhan,HubeiChina
Contact Supplier

53-86-1 Testosterone Isocaproate

  • Cas:53-86-1 Mf:C19h16clno4 Mw:357.79 Einecs:200-186-5 Product categories:Pharmaceuticals;Active pharmaceutical ingredients;Inhibitors;Intermediates & fine chemicals;Lipid signaling Chemical properties:Crystalline solid Assay:99% Usage:Antiinflammator...
  • China Hubei Yuancheng Saichuang Technology Co., Ltd [Manufacturer, Trading Company]
  • Tel: 86-027-50756243
  • Address: 496#Zhongshan Road, Wuchang, Wuhan, P.R.China wuhan,HebeiChina
Contact Supplier

Select to

References of 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
Title: Indomethacin
CAS Registry Number: 53-86-1
CAS Name: 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid
Synonyms: 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetic acid; indometacin
Trademarks: Bonidon (Mepha); Catlep (Sumitomo); Chrono-Indocid (Merck & Co.); Confortid (Alpharma); Dolcidium (Galephar); Elmetacin (Sankyo); Idomethine (Kowa); Inacid (Merck & Co.); Indacin (Merck & Co.); Indocid (Merck & Co.); Indocin (Merck & Co.); Indomed (Merck & Co.); Indomee (Merck & Co.); Indomod (Pfizer); Indoptic (Merck & Co.); Indoptol (Merck & Co.); Indoxen (Sigma-Tau); Inflazon (Taisho); Inteban (Sumitomo); Mikametan (Mikasa); Rheumacin LA (CP Pharm.); Serastar (Yamanouchi); Vonum (Sanofi-Synthelabo)
Molecular Formula: C19H16ClNO4
Molecular Weight: 357.79
Percent Composition: C 63.78%, H 4.51%, Cl 9.91%, N 3.91%, O 17.89%
Literature References: Nonsteroidal anti-inflammatory agent (NSAID); inhibits prostaglandin synthesis. Prepn: T. Y. Shen et al., J. Am. Chem. Soc. 85, 488 (1963); T. Y. Shen, US 3161654 (1964 to Merck & Co.). Alternate process: BE 679678 (1966 to Sumitomo). Anti-inflammatory and antipyretic activity: C. A. Winter et al., J. Pharmacol. Exp. Ther. 141, 369 (1963). Metabolic studies: D. W. Yesair et al., Biochem. Pharmacol. 19, 1579 (1970). Toxicity: C. D. Klaassen, Toxicol. Appl. Pharmacol. 38, 127 (1976). Review of discovery, pharmacology and mechanism of action: T. Y. Shen, C. A. Winter in Advances in Drug Research vol. 12, A. B. Simmons, Ed. (Academic Press, New York, 1977) pp 89-245; of clinical trials in osteoarthritis: W. M. O'Brien, Clin. Pharmacol. Ther. 9, 94-107 (1968); of role in ductus closure: S. M. Douidar et al., Dev. Pharmacol. Ther. 11, 196-212 (1988).
Properties: Crystals exhibiting polymorphism, mp for one form ~155°, for the other ~162°. uv max (ethanol): 230, 260, 319 nm (e 20800, 16200, 6290). pKa 4.5. Sol in ethanol, ether, acetone, castor oil. Practically insol in water. Stable in neutral or slightly acidic media; dec by strong alkali. LD50 i.p. in rats: 13 mg/kg (Klaassen).
Melting point: mp for one form ~155°, for the other ~162°
pKa: pKa 4.5
Absorption maximum: uv max (ethanol): 230, 260, 319 nm (e 20800, 16200, 6290)
Toxicity data: LD50 i.p. in rats: 13 mg/kg (Klaassen)
 
Derivative Type: Sodium salt trihydrate
CAS Registry Number: 74252-25-8
Trademarks: Indocin I.V. (Merck & Co.); Indocid PDA (Merck & Co.)
Molecular Formula: C19H15ClNNaO4.3H2O
Molecular Weight: 433.82
Percent Composition: C 52.60%, H 4.88%, Cl 8.17%, N 3.23%, Na 5.30%, O 25.82%
Properties: Pale yellow crystalline powder. pH of 1% soln: 8.4. Very sol in methanol; sol in water, ethanol. Very slightly sol in chloroform, acetone.
 
Derivative Type: Meglumine salt
Trademarks: Liometacen (Chiesi)
 
Therap-Cat: Anti-inflammatory; analgesic. For closure of patent ductus arteriosus in preterm infants.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Arylacetic Acid Derivatives.