CAS No 53684-49-4 , 2-Propanol,1-[(1,1-dimethylethyl)amino]-3-[2-[(tetrahydro-2-furanyl)methoxy]phenoxy]-

Name: 2-Propanol,1-[(1,1-dimethylethyl)amino]-3-[2-[(tetrahydro-2-furanyl)methoxy]phenoxy]-
Synonyms: Bufetolol;2-Propanol,1-[(1,1-dimethylethyl)amino]-3-[2-[(tetrahydro-2-furanyl)methoxy]phenoxy]-;
CAS Registry Number:53684-49-4
Flash Point: 241.9°C
Boiling Point: 476.4°Cat760mmHg
Density: 1.081g/cm³
Refractive index: 1.517
Flash Point: 241.9°C
Molecular Weight: 0
InChI: InChI=1/C18H29NO4/c1-18(2,3)19-11-14(20)12-22-16-8-4-5-9-17(16)23-13-15-7-6-10-21-15/h4-5,8-9,14-15,19-20H,6-7,10-13H2,1-3H3
Molecular Formula: C18H29 N O4
Molecular Structure:

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References of 2-Propanol,1-[(1,1-dimethylethyl)amino]-3-[2-[(tetrahydro-2-furanyl)methoxy]phenoxy]-

Title: Bufetolol
CAS Registry Number: 53684-49-4
CAS Name: 1-[(1,1-Dimethylethyl)amino]-3-[2-[(tetrahydro-2-furanyl)methoxy]phenoxy]-2-propanol
Synonyms: 1-(tert-butylamino)-3-[o-[(tetrahydrofurfuryl)oxy]phenoxy]-2-propanol
Molecular Formula: C18H29NO4
Molecular Weight: 323.43
Percent Composition: C 66.84%, H 9.04%, N 4.33%, O 19.79%
Literature References: b-Adrenergic blocker. Prepn: M. Nakanishi et al., DE 2024001; eidem, US 3723476 (1970, 1973, both to Yoshitomi); eidem, J. Med. Chem. 15, 45 (1972). Pharmacology: M. Nakanishi et al., Yakugaku Zasshi 91, 1037 (1971); ibid. 92, 375 (1972); Imamura et al., ibid. 1039. Metabolism: M. Nakanishi et al., ibid. 299; Oyo Yakuri 6, 479 (1972), C.A. 78, 66785b (1973). Toxicology: eidem, ibid. 485, 1267, C.A. 78, 66945d; 79, 337w (1973).
Properties: bp0.07 180-186°.
Boiling point: bp0.07 180-186°

Derivative Type: Hydrochloride
CAS Registry Number: 35108-88-4
Manufacturers' Codes: Y-6124
Trademarks: Adobiol (Yoshitomi)
Molecular Formula: C18H29NO4.HCl
Molecular Weight: 359.89
Percent Composition: C 60.07%, H 8.40%, N 3.89%, O 17.78%, Cl 9.85%
Properties: White crystals from methanol-isopropanol, mp 153.5-157°; also reported as mp 151-154°. (Diastereoisomer, mp 118°). Freely sol in water, methanol, glacial acetic acid. Very slightly sol in benzene. Practically insol in ether. Unstable on exposure to light.
Melting point: mp 153.5-157°; mp 151-154°; (Diastereoisomer, mp 118°)

Therap-Cat: Antiarrhythmic; antianginal.
Keywords: ?Adrenergic Blocker; Antianginal; Antiarrhythmic.