Home > Name List By n > N-(dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine

CAS No 54187-04-1 , N-(dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine

  • Name: N-(dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine
  • Synonyms: Rilmenidine [INN];Oxaminozoline;N-(dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine; 54187-04-1; Rilmenidinum [Latin]; Hyperium; Rilmenidia [Spanish];
  • CAS Registry Number:
  • Melting Point: 106 - 107
  • Density: 1.45 g/cm3
  • Water Solubility: H2O: 7.3 mg/mL in water
  • Safety Statements: S22;S24/25
  • EINECS: 259-021-0
  • Molecular Weight: 180.24684
  • InchiKey: CQXADFVORZEARL-UHFFFAOYSA-N
  • InChI: InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,
    11,12)
  • Risk Statements: S22;S24/25
  • Molecular Formula: C10H16N2O
  • Molecular Structure:CAS No:54187-04-1 N-(dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine
Search by region :

Select to

54187-04-1 2-Oxazolamine,N-(dicyclopropylmethyl)-4,5-dihydro-

Contact Supplier

54187-04-1 Rilmenidine

Contact Supplier

54187-04-1 RILMENIDINE HEMIFUMARATE

  • Germany BIOTREND Chemikalien GmbH [Manufacturer]
  • Tel: ++49 (0)2 21 9 49 83 20
  • Fax: ++49 (0)2 21 9 49 83 25
  • Address: BIOTREND Chemikalien GmbH
    Eupener Str. 157
    D - 50933 Cologne
    Germany null,nullGermany
Contact Supplier

54187-04-1 RILMENIDINE

  • China HANGZHOU THINK CHEMICAL CO. [Manufacturer]
  • Tel: +86-571-81956191/ +86-571-81956192
  • Fax: +86-571-81956190
  • Address: 425 MOGAN HILL ROAD ,
    HANGZHOU, 310011 CHINA null,nullChina
Contact Supplier

54187-04-1 Rilmenidine

  • China Facus Pharmaceutical Co., Ltd. [Manufacturers]
  • Tel: +86-(574)-6237-8411
  • Fax: +86-(574)-6237-8410
  • Address: 24Fl, Yuanjing Building, Beilun, Ningbo, Zhejiang 315800, Ningbo,ZhejiangChina
Contact Supplier

54187-04-1 RILMENIDINE

  • China SINOCO CHEMICAL CO., LIMITED [Importer/Exporter]
  • Tel: +86-571-81956191, 81956192
  • Fax: 86-571-81956190 88386326
  • Address: 425 Ruiqi Mansion Moganshan Road , Hangzhou 310011 China. Hangzhou,ZhejiangChina
Contact Supplier

54187-04-1 0790 RILMENIDINE HEMIFURAMATE

  • United States Tocris Bioscience [Manufacturer]
  • Tel: (800) 421-3701/ (636) 207-7651
  • Fax: (800) 483-1993 / (636) 207-7683
  • Address: Tocris Bioscience
    16144 Westwoods Business Park
    Ellisville, Missouri 63021
    USA null,nullUnited States
Contact Supplier

54187-04-1 Rilmenidine

  • United States Tecoland Corporation null
  • Tel: +1-(732)-603-9577
  • Fax: +1-(732)-906-1522
  • Address: 100 Menlo Park Drive, Suite 316, Edison, New Jersey 08837-2428, null,nullUnited States
Contact Supplier

54187-04-1 RILMENIDINE

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 null,nullUnited States
Contact Supplier

54187-04-1 RILMENIDINE

  • United States MINAKEM, L.L.C. [Manufacturer]
  • Tel: 201-225-9252/ + 33 3 20 64 68 40
  • Fax: 201-225-9253
  • Address: US Office:
    MINAKEM, L.L.C.
    411 Hackensack Avenue
    Continental Plaza ? 4th Floor
    Hackensack, New Jersey 07601 null,nullUnited States
Contact Supplier

Select to

References of N-(dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine
Title: Rilmenidine
CAS Registry Number: 54187-04-1
CAS Name: N-(Dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine
Synonyms: 2-[N-(dicyclopropylmethyl)amino]oxazoline; oxaminozoline
Manufacturers' Codes: S-3341
Molecular Formula: C10H16N2O
Molecular Weight: 180.25
Percent Composition: C 66.63%, H 8.95%, N 15.54%, O 8.88%
Literature References: a2-Adrenoceptor agonist. Prepn: C. Malen et al., DE 2362754; eidem, US 4102890 (1974, 1978 both to Sci. Union et Cie. - Soc. Franc. Recher. Med.). Adrenoceptor binding study: P. Guicheney et al., J. Pharmacol. 12, 255 (1981). Pharmacokinetics in hypertensive subjects: J. Velly et al., ibid. 13, 413 (1982). Animal pharmacology: M. Laubie et al., ibid. 16, 259 (1985); P. A. van Zwieten et al., Arch. Int. Pharmacodyn. 279, 130 (1986). Hypotensive effect in humans: K. Weerasuriya et al., Eur. J. Clin. Pharmacol. 27, 281 (1984). Mechanism of action study: R. E. Gomez et al., Eur. J. Pharmacol. 195, 181 (1991). Review: T. J. Verbeuren et al., Cardiovasc. Drug Rev. 8, 56-70 (1990).
Properties: Crystals from hexane, mp 106-107°.
Melting point: mp 106-107°
 
Derivative Type: Phosphate
Manufacturers' Codes: S-3341-3
Trademarks: Hyperium (Biopharma)
Molecular Formula: C10H16N2O.H3PO4
Molecular Weight: 278.24
Percent Composition: C 43.17%, H 6.88%, N 10.07%, O 28.75%, P 11.13%
Properties: pKa 9.3. Soly in H2O: ~19% w/v; in methanol: ~7% w/v; in chloroform and ethanol: ~0.7% w/v. LD50 orally in mice, rats: 375, 295 mg/kg (Verbeuren).
pKa: pKa 9.3
Toxicity data: LD50 orally in mice, rats: 375, 295 mg/kg (Verbeuren)
 
Derivative Type: Fumarate
Molecular Formula: C14H20N2O5
Molecular Weight: 296.32
Percent Composition: C 56.75%, H 6.80%, N 9.45%, O 27.00%
Properties: Crystals from ethanol, mp 170°.
Melting point: mp 170°
 
Therap-Cat: Antihypertensive.
Keywords: a-Adrenergic Agonist; Antihypertensive.