Home > Name List By e > ethyl (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4, 6,8-tetraenoate

CAS No 54350-48-0 , ethyl
(2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,
6,8-tetraenoate

  • Name: ethyl
    (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,
    6,8-tetraenoate
  • Synonyms: Ro-10-9359; Retinoid; Etretinato; Etretinatum; 54350-48-0;Tegison; Tigason; Ethyl etrinoate;ethyl
    (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,
    6,8-tetraenoate; Ro 10-9359;
  • CAS Registry Number:
  • Melting Point: 104-1050C
  • Flash Point: 219.4°C
  • Boiling Point: 506.4°C at 760 mmHg
  • Density: 1.006g/cm3
  • Refractive index: 1.544
  • Safety Statements: Human systemic effects: dermatitis, nail and hair changes, increased body temperature. Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
  • Flash Point: 219.4°C
  • EINECS: 259-119-3
  • Molecular Weight: 354.4825
  • InchiKey: HQMNCQVAMBCHCO-DJRRULDNSA-N
  • InChI: InChI=1S/C23H30O3/c1-8-26-23(24)14-17(3)11-9-10-16(2)12-13-21-18(4)15-22
    (25-7)20(6)19(21)5/h9-15H,8H2,1-7H3/b11-9+,13-12+,16-10+,17-14+
  • Molecular Formula: C23H30O3
  • Molecular Structure:CAS No:54350-48-0 ethyl<br />(2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,<br />6,8-tetraenoate

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References of ethyl
(2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,
6,8-tetraenoate
Title: Etretinate
CAS Registry Number: 54350-48-0
CAS Name: (all-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid ethyl ester
Manufacturers' Codes: Ro-10-9359
Trademarks: Tegison (Roche); Tigason (Roche)
Molecular Formula: C23H30O3
Molecular Weight: 354.48
Percent Composition: C 77.93%, H 8.53%, O 13.54%
Literature References: Aromatic analog of retinoic acid, q.v. Prepn: W. Bollag et al., DE 2414619; eidem, US 4105681 and US 4215215 (1974, 1978, 1980 all to Hoffmann-La Roche). Effects on skin metabolism: W. P. Raab, B. M. Gmeiner, Arch. Dermatol. Res. 256, 247 (1976). Toxicity study in organ culture: D. R. Bard, I. Lasnitzki, Br. J. Cancer 35, 110 (1977). Pharmacokinetics: R. Haenni, Dermatologica 157, Suppl, 5 (1978). Mutation study: H. J. Juhl et al., Mutat. Res. 58, 317 (1978). HPLC determn in plasma: R. Haenni et al., J. Chromatogr. 162, 615 (1979). Toxicology, carcinogenicity and teratogenicity study: J. J. Kamm, J. Am. Acad. Dermatol. 6, 652 (1982). Clinical evaluation in psoriatic arthritis: M. L. Ciompi et al., Int. J. Tissue React. 10, 25 (1988). Review: H. Mayer et al., Experientia 34, 1105-1119 (1978). Review of pharmacology and therapeutic efficacy: A. Ward et al., Drugs 26, 9-43 (1983); of clinical pharmacology: A. Vahlquist, O. Rollman, Dermatologica 175, Suppl. 1, 20-27 (1987). Book: The Retinoids Vol. 1-2, M. B. Sporn et al., Eds. (Academic Press, New York, 1984).
Properties: Crystals, mp 104-105°. LD50 in mice (1 day): >4000 mg/kg i.p. (Bollag). LD50 (20 day) in mice, rats (mg/kg): 1176, >2000 i.p.; >2000, >4000 orally (Kamm).
Melting point: mp 104-105°
Toxicity data: LD50 in mice (1 day): >4000 mg/kg i.p. (Bollag); LD50 (20 day) in mice, rats (mg/kg): 1176, >2000 i.p.; >2000, >4000 orally (Kamm)
 
Derivative Type: Free acid see Acitretin
 
Therap-Cat: Antipsoriatic.
Keywords: Antipsoriatic.