Home > Name List By d > D-Mannitol,1,6-bis[(2-chloroethyl)amino]-1,6-dideoxy-, dihydrochloride (9CI)

CAS No 551-74-6 , D-Mannitol,1,6-bis[(2-chloroethyl)amino]-1,6-dideoxy-, dihydrochloride (9CI)

  • Name: D-Mannitol,1,6-bis[(2-chloroethyl)amino]-1,6-dideoxy-, dihydrochloride (9CI)
  • Synonyms: Degranol;1,6-Bis(chloroethylamino)-1,6-dideoxy-D-mannitol dihydrochloride;Mannitol,1,6-bis[(2-chloroethyl)amino]-1,6-dideoxy-, dihydrochloride, D- (8CI);D-Mannitol,1,6-bis[(2-chloroethyl)amino]-1,6-dideoxy-, dihydrochloride (9CI); Dimesylmannitol hydrochloride; 1,6-Bis(b-chlorethylamino)-1,6-didesoxy-D-mannitoldihydrochloride; Degranol chinoin; 1,6-Bis[(2-chloroethyl)amino]-1,6-dideoxy-D-mannitoldihydrochloride; Mannomustinehydrochloride;Mannitol mustard dihydrochloride; NSC 9698; Mannomustine dihydrochloride;
  • CAS Registry Number:
  • Safety Statements: Poison by intravenous, subcutaneous, and parenteral routes. Experimental reproductive effects. Questionable carcinogen with experimental carcinogenic and neoplastigenic data. Human mutation data reported. A drug used for the treatment of malignant neoplasms. When heated to decomposition it emits very toxic fumes of HCl and NOx. See also MANNOMUSTINE.
  • Molecular Weight: 0
  • InChI: InChI=1S/C10H22Cl2N2O4.ClH/c11-1-3-13-5-7(15)9(17)10(18)8(16)6-14-4-2-12;/h7-10,13-18H,1-6H2;1H
  • Molecular Formula: C10H24Cl4N2O4
  • Molecular Structure:CAS No:551-74-6 D-Mannitol,1,6-bis[(2-chloroethyl)amino]-1,6-dideoxy-, dihydrochloride (9CI)

Related products

Select to

551-74-6 Mannomustine

Contact Supplier

551-74-6 MANNOMUSTINE 2HCL

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China null,nullChina
Contact Supplier

Select to

1/1
References of D-Mannitol,1,6-bis[(2-chloroethyl)amino]-1,6-dideoxy-, dihydrochloride (9CI)
Title: Mannomustine
CAS Registry Number: 551-74-6
CAS Name: 1,6-Bis(2-chloroethylamino)-1,6-dideoxy-D-mannitol dihydrochloride
Synonyms: 1,6-dideoxy-1,6-di(2-chloroethylamino)-D-mannitol dihydrochloride; 1,6-di(2-chloroethylamino)-1,6-dideoxy-D-mannitol dihydrochloride; mannitol nitrogen mustard; BCM
Trademarks: Degranol
Molecular Formula: C10H24Cl4N2O4
Molecular Weight: 378.12
Percent Composition: C 31.76%, H 6.40%, Cl 37.50%, N 7.41%, O 16.93%
Literature References: Prepn: Vargha et al., J. Chem. Soc. 1957, 805. Toxicity: Scherf et al., Arzneim.-Forsch. 20, 1467 (1970).
Properties: Crystals from 80% ethanol, dec 239-241°. [a]D20 +18.46° (c = 1.81 in H2O). (Free base, crystals, dec 278°). Sol in water; slightly sol in ethanol. Aq solns are mildly acidic and stable at room temps. Claimed to be considerably less toxic than mechlorethamine. LD50 i.v. in rats: 56 mg/kg (Scherf).
Optical Rotation: [a]D20 +18.46° (c = 1.81 in H2O)
Toxicity data: LD50 i.v. in rats: 56 mg/kg (Scherf)
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkylating Agents; Nitrogen Mustards.
 
 
Status: This monograph has been retired and is no longer subject to revision or update.