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CAS No 554-57-4 , N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide

  • Name: N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide
  • Synonyms: Methenamide; Neptazane; Metazolamida; 554-57-4; Metazolamide [DCIT]; N-Methylacetazolamide;N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide; Naptazane; Neptazaneat;
  • CAS Registry Number:
  • Melting Point: 208 ºC (DEC.)
  • Flash Point: 402°Cat760mmHg
  • Boiling Point: 402°Cat760mmHg
  • Density: 1.79g/cm3
  • Refractive index: 1.737
  • Safety Statements: R20/21/22;R40
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 402°Cat760mmHg
  • EINECS: 209-066-7
  • Molecular Weight: 236.27202
  • InchiKey: FLOSMHQXBMRNHR-UHFFFAOYSA-N
  • InChI: InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,
    12)
  • Risk Statements: S22;S36
  • Molecular Formula: C5H8N4O3S2
  • Molecular Structure:CAS No:554-57-4 N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide
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554-57-4 Methazolamide

  • Synonym: 2-acetylimino-3-methyl-delta(sup4)-1,3,4-thiadiazoline-5-sulfonamide;2-Acetylimino-3-methyl-delta4-1,3,4-thiadiazoline-5-sulfonamide;5-acetylimino-4-methyl-delta(sup2)-1,3,4-thiadiazoline-2-sulfonamide;5-Acetylimino-4-methyl-delta2-1,3,4-thi...
  • China Hubei Yuancheng Gongchuang Technology Co.,Ltd [Manufacturer]
  • Tel: 86-027-50756226
  • Address: No.496,Zhongshan Road, Wuhan, Hubei, China wuhan,HubeiChina
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554-57-4 Methazolamide

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554-57-4 METHAZOLAMIDE

  • United States NetQem, LLC [Manufacturer]
  • Tel: (919) 544-4122
  • Fax: (919) 544-4109
  • Address: NetQem, LLC
    P.O. Box 12091
    Research Triangle Park
    NC 27709, USA ,United States
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554-57-4 Methazolamide

  • United States CBSCHEM LIMITED []
  • Fax: (888) 557-9843
  • Address: 621 South 48th Street, Suite 115,Tempe, AZ 85281 ,United States
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554-57-4 Methazolamide

  • United States Tecoland Corporation []
  • Tel: +1-(732)-603-9577
  • Fax: +1-(732)-906-1522
  • Address: 100 Menlo Park Drive, Suite 316, Edison, New Jersey 08837-2428, ,United States
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554-57-4 METHAZOLAMIDE

  • China FAITH EAGLE (LABORATORY) LTD. [Manufacturers]
  • Tel: (+86-755) 82851290
  • Fax: +86-755-83164680 83662918
  • Address: 15A/F.,Block A,World Trade Plaza,8# FuHong Rd., FuTian,Shenzhen, China Shenzhen,GuangdongChina
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554-57-4 Methazolamide

  • China Porton Corporation []
  • Tel: 023 67038621 02367038639
  • Fax: 86-23-6703 8513
  • Address: Building 6, Sunteam Office Park, 18 West Honghu Road, Yubei District, Chongqing, 401121, China. ,China
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554-57-4 Methazolamide

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554-57-4 METHAZOLAMIDE

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China ,China
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References of N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide
Title: Methazolamide
CAS Registry Number: 554-57-4
CAS Name: N-[5-(Aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide
Synonyms: N-(4-methyl-2-sulfamoyl-D2-1,3,4-thiadiazolin-5-ylidene)acetamide; 5-acetylamino-4-methyl-D2-1,3,4-thiadiazoline-2-sulfonamide
Trademarks: Neptazane (Wyeth)
Molecular Formula: C5H8N4O3S2
Molecular Weight: 236.27
Percent Composition: C 25.42%, H 3.41%, N 23.71%, O 20.31%, S 27.14%
Literature References: Carbonic anhydrase inhibitor. Prepn: Young et al., J. Am. Chem. Soc. 78, 4649 (1956); US 2783241 (1957 to Am. Cyanamid); Pala, Farmaco Ed. Sci. 13, 650 (1958).
Properties: Crystals from water, mp 213-214°. pKa 7.30. uv max (95% ethanol): 254 nm (log e 3.66); (0.1N NaOH): 247 nm (log e 3.61).
Melting point: mp 213-214°
pKa: pKa 7.30
Absorption maximum: uv max (95% ethanol): 254 nm (log e 3.66); (0.1N NaOH): 247 nm (log e 3.61)
Therap-Cat: Diuretic.
Keywords: Antiglaucoma; Carbonic Anhydrase Inhibitor; Diuretic; Sulfonamide Derivatives.