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CAS No 555-30-6 , (2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid

  • Name: (2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid
  • Synonyms: Dopamet; Baypresol; Sedometil;(2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid; Sembrina; Alphamethyldopa;Aldomet; Dopegyt; Presolisin; Hyperpax;
  • CAS Registry Number:
  • Melting Point: ≥300 °C
  • Flash Point: 220.9°C
  • Boiling Point: 441.6°Cat760mmHg
  • Density: 1.403g/cm3
  • Refractive index: -14 ° (C=1, H2O)
  • Safety Statements: Poison by intraperitoneal route. Moderately toxic by ingestion and intravenous routes. Human systemic effects by ingestion: fasciculations, hallucinations, distorted perceptions, tremors, allergic dermatitis, necrotic gastrointestinal changes. An experimental teratogen. Human reproductive effects: menstrual cycle changes or disorders, effects on newborn including abnormal neonatal measures and growth statistics, biochemical and metabolic changes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: 220.9°C
  • EINECS: 209-089-2
  • Molecular Weight: 211.21452
  • InchiKey: CJCSPKMFHVPWAR-JTQLQIEISA-N
  • InChI: InChI=1S/C10H13NO4/c1-10(11,9(14)15)5-6-2-3-7(12)8(13)4-6/h2-4,12-13H,5,
    11H2,1H3,(H,14,15)/t10-/m0/s1
  • Risk Statements: S24/25:Avoidcontactwithskinandeyes.;
  • Molecular Formula: C10H13NO4
  • Molecular Structure:CAS No:555-30-6 (2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid
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555-30-6 alpha-methyldopa

  • "Appearance White or yellowish white ,crystalline powder or colourless or almost colourless crystals Solubility Slightly soluble in water ,very slightly soluble in ethanol(96%).It is freely soluble indilute mineral acids. Identification A.IR IR spect...
  • China Hangzhou Dingyan Chem Co.,Ltd [Manufacturer, Trading Company, Distributor/Wholesaler]
  • Tel: 86-571-88025800
  • Fax: 86-571-87156470
  • Address: Xiasha 571, 19TH Street E-COMMERCE 4A 601-602 , Jianggan Area hangzhou,ZhejiangChina

555-30-6 L-3-(3,4-DIHYDROXYPHENYL)-2-METHYLALANINE; 98%

  • Germany ABCR GmbH & Co KG [Manufacturer]
  • Tel: +49 721 95061-0
  • Fax: +49 721 95061-80
  • Address: Im Schlehert 10
    76187 Karlsruhe
    Germany ,Germany
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555-30-6 DL-METHYLDOPA, 99%

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
    17 Walnut St., Tai Kok Tsui, Kln,
    Hong Kong ,Hong kong
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555-30-6 Methyldopa

  • Name:Methyldopa Another name:3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine, sesquihydrate; alpha-Methyl-DOPA sesquihydrate; METHYLDOPA CAS NO: 555-30-6 EINECS: 209-089-2 Molecular formula:C10H13NO4 molecular weight:211.22
  • Min. Order: 10
  • FOB Price: USDfalse - false /
  • China Honrok BiotechCo.,Ltd [Manufacturer, Trading Company]
  • Tel: 86-531-69952680
  • Address: No 10 Huaneng Road Lixia District Jinan,ShandongChina
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555-30-6 alpha-methyldopa

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555-30-6 S]-(-)-ALPHA-METHYLDOPA

  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
    Werner-von-Siemensstr. 3
    93128 Regenstauf
    Germany ,Germany
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555-30-6 alpha-methyldopa

  • United States HBCChem, Inc. [Manufacturers]
  • Tel: +1-510-219-6317
  • Fax: +1-510-675-0318
  • Address: Union City,CaliforniaUnited States
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555-30-6 alpha-methyldopa

  • China Xilin Chemical Group Co., Ltd []
  • Tel: +86-(0)-15527136576
  • Fax: +86-(27)-83820093
  • Address: 16# Luojiashan, Wuchang District, Wuhan, Hubei 430071, ,China
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555-30-6 Methyldopa

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 ,United States
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555-30-6 Methyl Dopa

  • China Simag Chemicals [Manufacturer]
  • Tel: +86 592 2680277
  • Fax: +86 592 2680237
  • Address: Simag Chemicals
    A-9D Atlantic sea view city,
    No.9 Hubin West Rd.,
    Xiamen China. ,China
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References of (2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid
Title: Methyldopa
CAS Registry Number: 555-30-6
CAS Name: 3-Hydroxy-a-methyl-L-tyrosine
Synonyms: L-3-(3,4-dihydroxyphenyl)-2-methylalanine; L-a-methyl-3,4-dihydroxyphenylalanine; L-2-amino-2-methyl-3-(3,4-dihydroxyphenyl)propionic acid; a-methyldopa; AMD
Manufacturers' Codes: MK-351
Trademarks: Aldomet (Merck & Co.); Aldomin (Merck & Co.); Dopamet (Dumex); Dopegyt (Egis); Elanpres (Elan); Equibar (Aventis); Medopren (Malesci); Methoplain (Kowa Yakuhin); Sembrina (Orion); Presinol (Bayer)
Molecular Formula: C10H13NO4
Molecular Weight: 211.21
Percent Composition: C 56.87%, H 6.20%, N 6.63%, O 30.30%
Literature References: Exists as the sesquihydrate. Prepn: Pfister, Stein, US 2868818 (1959 to Merck & Co.). Resolution: Jones et al., US 3158648 (1964 to Merck & Co.); cf. Slates et al., J. Org. Chem. 29, 1424 (1964). Resolution and configuration: Tristram, ibid. 2053. Synthesis from asymmetric intermediates: Reinhold et al., J. Org. Chem. 33, 1209 (1968). Prepn of the ethyl ester hydrochloride: FR M2153 (1963 to Merck & Co.); of pharmaceutical dosage forms: Marcus, US 3230143 (1966 to Merck & Co.). Mode of action: Finch, Haeusler, Br. J. Pharmacol. 45, 167p (1972); Day et al., ibid. 168p. Review of pharmacology: A. Scriabine, Ed. in Pharmacology of Antihypertensive Drugs (Raven, New York, 1980) pp 43-54.
 
Derivative Type: L-Form sesquihydrate
Properties: Crystals from water. Minute anhydr crystals from methanol, considerably hygroscopic, dec ~300°. [a]D23 -4.0 ± 0.5° (c = 1 in 0.1N HCl). uv max: 281 nm (e 2780). Soly in water at 25°: ~10 mg/ml. pH of satd aq soln about 5.0. (Soly of D-form in water at 25°: ~10 mg/ml, of DL-form: ~18 mg/ml) Practically insol in the common organic solvents. Sol in dil mineral acids.
Optical Rotation: [a]D23 -4.0 ± 0.5° (c = 1 in 0.1N HCl)
Absorption maximum: uv max: 281 nm (e 2780)
 
Derivative Type: Ethyl ester hydrochloride
CAS Registry Number: 2508-79-4
Synonyms: Methyldopate hydrochloride
Molecular Formula: C12H18ClNO4
Molecular Weight: 275.73
Percent Composition: C 52.27%, H 6.58%, Cl 12.86%, N 5.08%, O 23.21%
Properties: After drying, mol wt 275.7 (1 mg = 0.77 mg of the free acid). Soluble in water to the extent of 10-300 mg/ml at pH 2-7. May be stabilized with sodium bisulfite and/or disodium EDTA.
 
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive.