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CAS No 555-84-0 , 1-[(E)-(5-nitrofuran-2-yl)methylideneamino]imidazolidin-2-one

  • Name: 1-[(E)-(5-nitrofuran-2-yl)methylideneamino]imidazolidin-2-one
  • Synonyms: Oxifuradene;1-[(E)-(5-nitrofuran-2-yl)methylideneamino]imidazolidin-2-one;NIFURADENE; Oxafurandene; Oxafuradene; NF 246; Nifuradine; Renafur; Oxyfuradene; NSC-6470; Nifuraden;
  • CAS Registry Number:
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.67g/cm3
  • Refractive index: 1.71
  • Safety Statements: Suspected carcinogen with experimental carcinogenic data. Moderately toxic by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: °C
  • Molecular Weight: 224.17352
  • InchiKey: VSVAVMVWTLLTCH-BJMVGYQFSA-N
  • InChI: InChI=1S/C8H8N4O4/c13-8-9-3-4-11(8)10-5-6-1-2-7(16-6)12(14)15/h1-2,5H,
    3-4H2,(H,9,13)/b10-5+
  • Molecular Formula: C8H8N4O4
  • Molecular Structure:CAS No:555-84-0 1-[(E)-(5-nitrofuran-2-yl)methylideneamino]imidazolidin-2-one
References of 1-[(E)-(5-nitrofuran-2-yl)methylideneamino]imidazolidin-2-one
Title: Nifuradene
CAS Registry Number: 555-84-0
CAS Name: 1-[[(5-Nitro-2-furanyl)methylene]amino]-2-imidazolidinone
Synonyms: oxafuradene (rescinded)
Manufacturers' Codes: NF-246; NSC-6470
Trademarks: Renafur (Eaton)
Molecular Formula: C8H8N4O4
Molecular Weight: 224.17
Percent Composition: C 42.86%, H 3.60%, N 24.99%, O 28.55%
Literature References: Prepn: Gever, Michels, US 2746960 (1956 to Norwich Pharm.); eidem, J. Am. Chem. Soc. 78, 5349 (1956); Michels, US 2776979 (1957 to Norwich Pharm.). Toxicity data: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).
Properties: Lemon-yellow solid from nitromethane, mp 261.5-263° (dec). Turns orange on standing, on washing with ethanol or on heating at 75-85°. uv max (water): 387.5, 273 nm (e 17550, 13200). Soly in water: 88-109 mg/l. LD50 orally in rats: 1681 mg/kg (Goldenthal).
Melting point: mp 261.5-263° (dec)
Absorption maximum: uv max (water): 387.5, 273 nm (e 17550, 13200)
Toxicity data: LD50 orally in rats: 1681 mg/kg (Goldenthal)
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Synthetic); Nitrofurans.
 
 
Status: This monograph has been retired and is no longer subject to revision or update.