Title: Colloidal Bismuth Subcitrate
CAS Registry Number: 57644-54-9
Synonyms: CBS
Trademarks: De-Nol (Yamanouchi); De-Noltab (Yamanouchi); Duosol (Interdelta); Ulcerone (Yamanouchi)
Literature References: Cytoprotective, polymeric bismuth citrato complex; also known as
tripotassium dicitrato bismuthate. General prepn of colloidal bismuth solution: L. Vanino, cited in
Mellor's vol. IX, 598 (1929). Manufacturing processes: C. J. McLoughlin, R. B. Himstedt,
DE 2501787; P. J. H. Bos
et al., EP 75992;
eidem, US 4801608 (1975, 1985, 1989 all to Gist-Brocades). Analytical study: D. R. Williams,
J. Inorg. Nucl. Chem. 39, 711 (1977). Crystal structure: E. Asato
et al., Chem. Lett. 1992, 1967. Pharmacology: J. Wieriks
et al., Scand. J. Gastroenterol. 17, Suppl. 80, 11 (1982). Modes of action: D. W. R. Hall,
ibid. 24, Suppl. 157, 3 (1989); S. P. Lee,
ibid. 26, Suppl. 185, 1 (1991). Pharmacokinetics and safety: L. Z. Benet
ibid. 29. Symposia on pharmacology and clinical efficacy:
ibid. 21, Suppl. 122, 1-54 (1986);
Digestion 37, Suppl. 2, 1-64 (1987). Clinical trials in
Helicobacter pylori associated gastritis and ulcer: T. Rokkas
et al., Gut 29, 1386 (1988); W. A. de Boer
et al., Am. J. Gastroenterol. 89, 1993 (1994).
Properties: White, amorphous powder. Sol in water, dil alkali, ammonia. Forms precipitate of bismuth oxychloride and bismuth citrate at pH <5.
Therap-Cat: Antiulcerative.
Keywords: Antiulcerative.
