Home > Name List By 2 > 2-[[2-[bis(2-hydroxyethyl)amino]-4,8-di(piperidin-1-yl)pyrimido[5, 4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol

CAS No 58-32-2 , 2-[[2-[bis(2-hydroxyethyl)amino]-4,8-di(piperidin-1-yl)pyrimido[5,
4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol

  • Name: 2-[[2-[bis(2-hydroxyethyl)amino]-4,8-di(piperidin-1-yl)pyrimido[5,
    4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol
  • Synonyms: Cardioflux; Kurantil;2-[[2-[bis(2-hydroxyethyl)amino]-4,8-di(piperidin-1-yl)pyrimido[5,
    4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol; Dipyudamine; Dipyridamine; Persantine; Curantyl; Dipyridamol; Stimolcardio;Persantin;
  • CAS Registry Number:
  • Melting Point: 165-166 ºC
  • Density: 1.352 g/cm3
  • Refractive index: 1.666
  • Water Solubility: DMSO: soluble in water
  • Safety Statements: R36/37/38
  • Hazard Symbols: Xi: Irritant;
  • EINECS: 200-374-7
  • Molecular Weight: 504.6256
  • InchiKey: IZEKFCXSFNUWAM-UHFFFAOYSA-N
  • InChI: InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-
    4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,
    1-18H2
  • Risk Statements: S26;S36
  • Molecular Formula: C24H40N8O4
  • Molecular Structure:CAS No:58-32-2 2-[[2-[bis(2-hydroxyethyl)amino]-4,8-di(piperidin-1-yl)pyrimido[5,<br />4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol
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58-32-2 Dipyridamole

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58-32-2 SC-200717 DIPYRIDAMOLE

  • United States Santa Cruz Biotechnology, Inc. [Manufacturer]
  • Tel: 831-457-3800/ 800-457-3801
  • Fax: 831-457-3801
  • Address: Santa Cruz Biotechnology, Inc.
    2145 Delaware Ave.
    Santa Cruz, CA 95060 ,United States
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58-32-2 Dipyridamole

  • China Kingland Chemicals Company Limited [Manufacturers]
  • Tel: +86-571-87211518,87229835
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  • Address: Room No. 1806-1808, Jinfeng Mansion, No.281 Zhong He Zhong Road, Hangzhou, China. ,zhejiangChina
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58-32-2 DIPYRIDAMOLE

  • China Ancheng Pharma Limited [Manufacturers]
  • Tel: +86-755-82713308
  • Fax: 0086-755-82713413
  • Address: Flat 1812, 18/F., Min Hua Building, 7 Jing Tian Bei Steet, Futian District,Shenzhen,China Shenzhen,guangdongChina
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58-32-2 Dipyridamole

  • Dipyridamole
  • China Hallopharma [Manufacturer]
  • Tel: 0086-23-67030808
  • Fax: 0086-23-67030818
  • Address: 17F,Venus Science Incubate Center,No.60 Xingguang Road,New North Zone,401121 ChongqingCHINA Chongqing,China
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58-32-2 Dipyridamole

  • Dipyridamole
  • China Inter-Chemical [Manufacturer]
  • Tel: 0086-23-67030808
  • Fax: 0086-23-67030818
  • Address: 17F,Venus Science Incubate Center,No.60 Xingguang Road,New North Zone,401121 ChongqingCHINA Chongqing,China
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58-32-2 Dipyridamole

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58-32-2 Dipyridamole

  • China Saniver Limited []
  • Fax: +86-21-62882088 +86-852-23333065
  • Address: 805 Harbour Centre, Tower 2, 8 Hok Cheung St., Hunghom, Kowloon, Hong Kong. ,China
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58-32-2 DIPYRIDAMOLE

  • China Xingcheng Chempharm Co., Ltd [Manufacturer]
  • Tel: +86-576-88525005/ +86-576-88886292
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  • Address: B Area, 10F, Yaoda Mansion, 289, Shifu Road, Taizhou, Zhejiang, China 318000 ,China
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58-32-2 DIPYRIDAMOLE

  • Canada TLC PharmaChem., Inc. [Manufacturer]
  • Tel: 905-760-1098
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  • Address: TLC PharmaChem., Inc.
    5-150 Connie Crescent
    Concord, Ontario
    L4K 1L9, Canada ,Canada
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References of 2-[[2-[bis(2-hydroxyethyl)amino]-4,8-di(piperidin-1-yl)pyrimido[5,
4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol
Title: Dipyridamole
CAS Registry Number: 58-32-2
CAS Name: 2,2¢,2¢¢,2¢¢¢-[(4,8-Di-1-piperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetrakisethanol
Synonyms: 2,6-bis(diethanolamino)-4,8-dipiperidinopyrimido-[5,4-d]pyrimidine
Manufacturers' Codes: NSC-515776; RA-8
Trademarks: Anginal (Yamanouchi); Cardoxin (RAFA); Cleridium (Marcofina); Coridil (Delalande); Coronarine (NEGMA); Curantyl (Berlin-Chemie); Dipyridan (Hokuriku); Gulliostin (Taiyo); Natyl (Interdelta); Peridamol (Boehringer, Ing.); Persantine (Boehringer, Ing.); Piroan (Towa Yakuhin); Prandiol (Bottu); Protangix (Lefrancq)
Molecular Formula: C24H40N8O4
Molecular Weight: 504.63
Percent Composition: C 57.12%, H 7.99%, N 22.21%, O 12.68%
Literature References: Phosphodiesterase inhibitor that reduces platelet aggregation; also acts as a coronary vasodilator. Prepn: GB 807826; F. G. Fischer, et al., US 3031450 (1959, 1962 both to Thomae). Activity studies: Saraf, Seth, Indian J. Physiol. Pharmacol. 15, 135 (1971). Toxicological study: F. Takenaka et al., Arzneim.-Forsch. 22, 892 (1972). Symposium on pharmacology and clinical experience as antithrombotic: Thromb. Res. 60, Suppl. 12, 1-99 (1990). Review of use as pharmacological stress agent in echocardiography: M. B. Buchalter et al., Postgrad. Med. J. 66, 531-535 (1990); in 201Tl cardiac imaging: S. G. Beer et al., Am. J. Cardiol. 67, Suppl., 18D-26D (1991).
Properties: Deep yellow needles from ethyl acetate, mp 163°. Bitter taste. Slightly sol in H2O; sol in dil acid having a pH of 3.3 or below; very sol in methanol, ethanol, chloroform; not too sol in acetone, benzene, ethyl acetate. Solns are yellow and show strong blue-green fluorescence. LD50 in rats: 8.4 g/kg orally; 208 mg/kg i.v. (Takenaka).
Melting point: mp 163°
Toxicity data: LD50 in rats: 8.4 g/kg orally; 208 mg/kg i.v. (Takenaka)
 
Derivative Type: Combination with aspirin
Trademarks: Aggrenox (Boehringer, Ing.)
Literature References: Review of pharmacology and clinical efficacy in secondary prevention of stroke: P. S. Hervey, K. L. Goa, Drugs 58, 469-475 (1999).
 
Therap-Cat: Antithrombotic; diagnostic aid (cardiac stress testing).
Keywords: Antithrombotic; Diagnostic Aid; Phosphodiesterase Inhibitor.