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CAS No 59-66-5 , N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide

  • Name: N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
  • Synonyms: Acetamox;Diamox; Dehydratin;N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide; Diluran; Diacarb; Edemox; Defiltran; Acetazolamid; Glaupax;
  • CAS Registry Number:
  • Transport: 2811
  • Melting Point: 256-261 ºC
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.744 g/cm3
  • Water Solubility: <0.1 G/100 ML AT 22 ºC
  • Safety Statements: R36/38
  • Hazard Symbols: Xi: Irritant;
  • Flash Point: °C
  • EINECS: 200-440-5
  • Molecular Weight: 222.24544
  • InchiKey: BZKPWHYZMXOIDC-UHFFFAOYSA-N
  • InChI: InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,
    11)(H,6,7,9)
  • Risk Statements: S26
  • Molecular Formula: C4H6N4O3S2
  • Molecular Structure:CAS No:59-66-5 N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide

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References of N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
Title: Acetazolamide
CAS Registry Number: 59-66-5
CAS Name: N-[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamide
Synonyms: 5-acetamido-1,3,4-thiadiazole-2-sulfonamide; 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide
Manufacturers' Codes: 6063
Trademarks: Acetamox (Tobishi-Santen); Atenezol (Tsuruhara); Défiltran (Gallier); Diamox (Barr); Didoc (Sawai); Diuriwas (IFI); Donmox (Horita); Edemox (Wassermann); Fonurit (Chinoin); Glaupax (Erco)
Molecular Formula: C4H6N4O3S2
Molecular Weight: 222.25
Percent Composition: C 21.62%, H 2.72%, N 25.21%, O 21.60%, S 28.85%
Literature References: Carbonic anhydrase inhibitor. Prepn: R. O. Roblin, J. W. Clapp, J. Am. Chem. Soc. 72, 4890 (1950); J. W. Clapp, R. O. Roblin, US 2554816 (1951 to Am. Cyanamid). HPLC determn in pharmaceuticals: Z. S. Gomaa, Biomed. Chromatogr. 7, 134 (1993). Effect on retinal circulation: S. M. B. Rassam et al., Eye 7, 697 (1993). Clinical trial in postoperative elevation of intraocular pressure: I. D. Ladas et al., Br. J. Ophthalmol. 77, 136 (1993). Comprehensive description: J. Parasrampuria, Anal. Profiles Drug Subs. Excip. 22, 1-32 (1993). Review of efficacy in acute mountain sickness: L. D. Ried et al., J. Wilderness Med. 5, 34-48 (1994).
Properties: Crystals from water, mp 258-259° (effervescence). Weak acid. pKa 7.2. Sparingly sol in cold water. Slightly sol in alcohol, acetone. Practically insol in carbon tetrachloride, chloroform, ether. Soly (mg/ml): polyethylene glycol-400 87.81; propylene glycol 7.44; ethanol 3.93; glycerin 3.65; water 0.72.
Melting point: mp 258-259° (effervescence)
pKa: pKa 7.2
 
Derivative Type: Sodium salt
CAS Registry Number: 1424-27-7
Trademarks: Vetamox (Am. Cyanamid)
 
Therap-Cat: Antiglaucoma; diuretic; in treatment of acute mountain sickness.
Therap-Cat-Vet: Diuretic.
Keywords: Antiglaucoma; Carbonic Anhydrase Inhibitor; Diuretic; Sulfonamide Derivatives.