Home > Name List By other > [(8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,8,9,11,12, 14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl]...

CAS No 595-33-5 , [(8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,8,9,11,12,
14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate

  • Name: [(8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,8,9,11,12,
    14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate
  • Synonyms: Ovaban; 595-33-5;Megace; Ovarid; Magestin; Niagestin;[(8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,8,9,11,12,
    14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate; Megeron; Megace ES; Megestryl acetate;
  • CAS Registry Number:
  • Melting Point: 214 ºC
  • Flash Point: 218.5°C
  • Boiling Point: 507.1°Cat760mmHg
  • Density: 1.15g/cm3
  • Refractive index: 11 ° (C=2, CHCl3)
  • Safety Statements: R40;R48
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 218.5°C
  • EINECS: 209-864-5
  • Molecular Weight: 384.50848
  • InchiKey: RQZAXGRLVPAYTJ-GQFGMJRRSA-N
  • InChI: InChI=1S/C24H32O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20
    (18)8-11-24(23,15(2)25)28-16(3)26/h12-13,18-20H,6-11H2,1-5H3/t18-,19+,
    20+,22-,23+,24+/m1/s1
  • Risk Statements: S22;S24/25
  • Molecular Formula: C24H32O4
  • Molecular Structure:CAS No:595-33-5 [(8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,8,9,11,12,<br />14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate

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References of [(8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,8,9,11,12,
14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate
Title: Megestrol Acetate
CAS Registry Number: 595-33-5
CAS Name: 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate
Synonyms: 17a-acetoxy-6-methylpregna-4,6-diene-3,20-dione; 6-dehydro-6-methyl-17a-acetoxyprogesterone; 6-methyl-D4,6-pregnadien-17a-ol-3,20-dione acetate
Trademarks: Maygace (BMS); Megace (BMS); Megestat (BMS); Megestil (Boehringer, Mann.); Nia (Novo); Niagestin (Novo); Ovaban (Schering)
Molecular Formula: C24H32O4
Molecular Weight: 384.51
Percent Composition: C 74.97%, H 8.39%, O 16.64%
Literature References: Orally active progestogen; formerly used in combinations as oral contraceptive. Prepn: Ringold et al., J. Am. Chem. Soc. 81, 3712 (1959); Dodson, Sollman, US 2891079 (1959 to Searle); Kirk et al., GB 870286 C.A. 56, 10248i (1962), and US 3356573 (1967 to Brit. Drug Houses); Cross, US 3400137 (1968 to Syntex). Biological effectiveness studies: Chang, Kincl, Steroids 12, 689 (1968). Metabolic studies: Cooper, Kellie, ibid. 11, 133 (1968). Soly and diffusion studies: Sundaram, Kincl, ibid. 12, 517 (1968). Comparative clinical trial with tamoxifen in metastatic breast cancer: J. C. Allergra et al., Semin. Oncol. 12, Suppl. 6, 61 (1985). Evaluation in prevention of hot flashes: C. L. Loprinzi et al., N. Engl. J. Med. 331, 347 (1994). Review of carcinogenicity studies: IARC Monographs 21, 431-439 (1979).
Properties: Crystals from methanol, mp 214-216°. Soly at 37°: in water (2 mg/ml); in plasma (24 mg/ml). [a]D24 +5° (chloroform). uv max (ethanol): 287 nm (log e 4.40).
Melting point: mp 214-216°
Optical Rotation: [a]D24 +5° (chloroform)
Absorption maximum: uv max (ethanol): 287 nm (log e 4.40)
 
Derivative Type: Mixture with ethinyl estradiol
CAS Registry Number: 8064-66-2
Trademarks: Co-Ervonum (Glaxo); Kombiquens (Novo); Noval (Yamanouchi); Nuvacon (BDH); Planovin (Novo); Tri-Ervonum (Glaxo); Volidan (BDH; Searle); Weradys (Weimer)
 
Derivative Type: Mixture with mestranol
CAS Registry Number: 8064-51-5
Trademarks: Delpregnin (Novo)
 
Therap-Cat: Progestogen. Palliative treatment of breast and endometrial carcinoma.
Therap-Cat-Vet: Progestogen. Estrus regulator.
Keywords: Antineoplastic (Hormonal); Progestogens; Progestogen.