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CAS No 59989-18-3 , 2,4(1H,3H)-Pyrimidinedione,5-ethynyl-

  • Name: 2,4(1H,3H)-Pyrimidinedione,5-ethynyl-
  • Synonyms: 5-Ethynyluracil;776C85; Eniluracil;2,4(1H,3H)-Pyrimidinedione,5-ethynyl-; NSC 687296;
  • CAS Registry Number:
  • Density: 1.39g/cm3
  • Refractive index: 1.589
  • Molecular Weight: 136.10816
  • InChI: InChI=1/C6H4N2O2/c1-2-4-3-7-6(10)8-5(4)9/h1,3H,(H2,7,8,9,10)
  • Molecular Formula: C6H4 N2 O2
  • Molecular Structure:CAS No:59989-18-3 2,4(1H,3H)-Pyrimidinedione,5-ethynyl-

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References of 2,4(1H,3H)-Pyrimidinedione,5-ethynyl-
Title: Eniluracil
CAS Registry Number: 59989-18-3
CAS Name: 5-Ethynyl-2,4(1H,3H)-pyrimidinedione
Synonyms: 5-ethynyluracil; 5-EU
Manufacturers' Codes: 776C85
Molecular Formula: C6H4N2O2
Molecular Weight: 136.11
Percent Composition: C 52.95%, H 2.96%, N 20.58%, O 23.51%
Literature References: Irreversible inhibitor of dihydropyrimidine dehydrogenase, the rate-determining enzyme in catabolism of 5-fluorouracil, q.v. Prepn: J. Perman et al., Tetrahedron Lett. 1976, 2427; P. J. Barr et al., Nucleic Acids Res. 3, 2845 (1976). Large scale synthesis: N. G. Kundu, S. A. Schmitz, J. Heterocycl. Chem. 19, 463 (1982). Crystal structure determn: M. Sacchetti et al., J. Pharm. Sci. 90, 1049 (2001). Mechanism-based inactivation of dihydropyrimidine dehydrogenase: D. J. T. Porter et al., J. Biol. Chem. 267, 5236 (1992). Prolongs plasma concentration of 5-fluorouracil: D. P. Baccanari et al., Proc. Natl. Acad. Sci. USA 90, 11064 (1993). Clinical safety and efficacy: R. A. Humerickhouse et al., Clin. Cancer Res. 5, 291 (1999). Clinical study with 5-fluorouracil in advanced pancreatic cancer: M. L. Rothenberg et al., Ann. Oncol. 13, 1576 (2002); in metastatic/advanced colorectal cancer: R. L. Schilsky et al., J. Clin. Oncol. 20, 1519 (2002). Review of clinical development: J. A. Hohneker, Oncology 12, 52-56 (1998).
Properties: Cream colored solid from methanol-water, mp 320° (dec). d 1.527. uv max (methanol): 284, 225 nm (e 9450, 10330).
Melting point: mp 320° (dec)
Absorption maximum: uv max (methanol): 284, 225 nm (e 9450, 10330)
Density: d 1.527
Therap-Cat: Antineoplastic adjunct (chemomodulator).
Keywords: Antineoplastic Adjunct; Chemomodulator.