Home > Name List By 2 > 2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1, 3-thiazole-4-carboxamide

CAS No 60084-10-8 , 2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,
3-thiazole-4-carboxamide

  • Name: 2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,
    3-thiazole-4-carboxamide
  • Synonyms: Tiazofurine; Tiazofurina;2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,
    3-thiazole-4-carboxamide; NSC 286193; Tiazole; NSC-286193; Tiazofurina [Spanish];Riboxamide; Tiazofurinum [Latin]; Tiazofurinum;
  • CAS Registry Number:
  • Flash Point: 341.6°C
  • Boiling Point: 641.3°C at 760 mmHg
  • Density: 1.648g/cm3
  • Refractive index: 1.674
  • Safety Statements: Moderately toxic by intravenous and intraperitoneal routes. Human systemic effects by intravenous route: headache, convulsions, and musculo-skeletal changes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of SOx and NOx.
  • Flash Point: 341.6°C
  • Molecular Weight: 260.26698
  • InchiKey: FVRDYQYEVDDKCR-DBRKOABJSA-N
  • InChI: InChI=1S/C9H12N2O5S/c10-8(15)3-2-17-9(11-3)7-6(14)5(13)4(1-12)16-7/h2,
    4-7,12-14H,1H2,(H2,10,15)/t4-,5-,6-,7-/m1/s1
  • Molecular Formula: C9H12N2O5S
  • Molecular Structure:CAS No:60084-10-8 2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,<br />3-thiazole-4-carboxamide

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References of 2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,
3-thiazole-4-carboxamide
Title: Tiazofurin
CAS Registry Number: 60084-10-8
CAS Name: 2b-D-Ribofuranosyl-4-thiazolecarboxamide
Synonyms: riboxamide; TCAR
Manufacturers' Codes: CI-909; NSC-286193
Trademarks: Tiazole (ICN)
Molecular Formula: C9H12N2O5S
Molecular Weight: 260.27
Percent Composition: C 41.53%, H 4.65%, N 10.76%, O 30.74%, S 12.32%
Literature References: Nucleoside analog that inhibits inosine monophosphate dehydrogenase (IMPDH). Prepn: M. Fuertes et al., J. Org. Chem. 41, 4074 (1976); and antiviral activity: P. C. Srivastava et al., J. Med. Chem. 20, 256 (1977). Structure-activity study: G. Gebeyehu et al., ibid. 28, 99 (1985). HPLC determn in plasma: R. W. Klecker, Jr., J. M. Collins, J. Chromatogr. 307, 361 (1984). Clinical pharmacokinetics: D. Raghavan et al., Cancer Chemother. Pharmacol. 16, 160 (1986). Clinical evaluation in leukemia: G. Tricot et al, Int. J. Cell Cloning 8, 161 (1990). Series of articles on pharmacology and clinical experience: Anticancer Res. 16, 3307-3354 (1996).
Properties: Crystals from ethanol-ethyl acetate, mp 145-146°. [a]D25 -9° (c = 0.5 in ethanol). uv max in ethanol: 215, 237 nm (e 9450, 7625).
Melting point: mp 145-146°
Optical Rotation: [a]D25 -9° (c = 0.5 in ethanol)
Absorption maximum: uv max in ethanol: 215, 237 nm (e 9450, 7625)
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Antimetabolites; Purine Analogs; IMPDH Inhibitor.