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CAS No 61036-64-4 , Teicoplanin A2

  • Name: Teicoplanin A2
  • Synonyms: SF 8327 factor A2; LS-148650; Teicoplanin A 2 (9CI);Teicoplanin A 2; Teicoplanin A2 complex;Teicoplanin A2;
  • CAS Registry Number:
  • Melting Point: 260 ºC
  • Safety Statements: Poison by intravenous route. Moderately toxic by subcutaneous and intraperitoneal routes.
  • Molecular Weight: 1921.69496
  • InchiKey: LCTCUBQFWLTHNS-MDZDMXLPSA-N
  • InChI: InChI=1S/C90H99Cl2N9O34/c1-5-6-7-8-9-10-11-12-60(110)95-69-76(116)73
    (113)58(32-103)132-89(69)135-80-55-27-41-28-56(80)128-51-20-16-39(23-46
    (51)92)79(134-88-68(94-35(3)105)75(115)72(112)57(31-102)131-88)70-86
    (124)99-66(87(125)126-4)44-29-42(106)30-54(130-90-78(118)77(117)74(114)
    59(33-104)133-90)61(44)43-21-37(14-17-47(43)107)63(82(120)101-70)96-84
    (122)65(41)97-83(121)64-40-24-49(109)34(2)52(26-40)129-53-25-36(13-18-48
    (53)108)62(93)81(119)100-67(85(123)98-64)71(111)38-15-19-50(127-55)45
    (91)22-38/h9-10,13-30,57-59,62-79,88-90,102-104,106-109,111-118H,5-8,
    11-12,31-33,93H2,1-4H3,(H,94,105)(H,95,110)(H,96,122)(H,97,121)(H,98,
    123)(H,99,124)(H,100,119)(H,101,120)/b10-9+
  • Molecular Formula: C90H99Cl2N9O34
  • Molecular Structure:CAS No:61036-64-4 Teicoplanin A2

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61036-64-4 Teicoplanin A 2 (9CI)

  • China Taiyuan RHF CO., ltd. [Manufacturers]
  • Tel: 0351-7436719
  • Fax: +86-351-7436719
  • Address: Shuangta South Alley 46,2-1, YingZe Area,Taiyuan, ShanXi ,ShanXiChina
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61036-64-4 Teicoplanin

  • United States LGM Pharma [Manufacturer]
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61036-64-4 Teicoplanin

  • China Kouting Chemical Co.,Ltd [Importer/Exporter]
  • Tel: +86-(21)-58116473
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  • Address: Hunan Road, Pudong New District, Shanghai, Shanghai 201318, shanghai,shanghaiChina
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61036-64-4 Teicoplanin

  • China Xingcheng Chempharm Co., Ltd [Manufacturer]
  • Tel: +86-576-88525005/ +86-576-88886292
  • Fax: +86-576-88225056
  • Address: B Area, 10F, Yaoda Mansion, 289, Shifu Road, Taizhou, Zhejiang, China 318000 ,China
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61036-64-4 Teicoplanin

  • China Facus Pharmaceutical Co., Ltd. [Manufacturers]
  • Tel: +86-(574)-6237-8411
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  • Address: 24Fl, Yuanjing Building, Beilun, Ningbo, Zhejiang 315800, Ningbo,ZhejiangChina
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61036-64-4 Teicoplanin

  • China TaiZhou HiKong Chemical Co., Ltd. []
  • Tel: +86-18967213045,13957694715
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  • Address: Taizhou Economic Technical Development Zone, Taizhou, Zhejiang 318000, ,China
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61036-64-4 Teicoplanin

  • China Nanjing Samwon International Limited [Importer/Exporter]
  • Tel: +86-(25)-84873444
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  • Address: 1108, BLDG B, New Century Plaza, No 1, South Taiping Rd., Nanjing, Jiangsu 210002, Nanjing,JiangsuChina
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61036-64-4 Teicoplanin A 2 (9CI)

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61036-64-4 TEICOPLANIN

  • China HANGZHOU ONICON CHEMICAL CO.,LTD [Manufacturer]
  • Tel: +86-571-85054016/ +86-571-85104679
  • Fax: +86-571-85054082
  • Address: HANGZHOU ONICON CHEMICAL CO.,LTD
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    E-Mail1: cjw9999@163.com ,China
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61036-64-4 Teicoplanin

  • Hong kong Leawell International Limited [Importer/Exporter]
  • Tel: +852-(2576)-0298
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  • Address: 18/F Catic Plaza, 8 Causeway Road Causeway Bay, Guangzhou,GuangdongHong kong
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References of Teicoplanin A2
Title: Teicoplanin
CAS Registry Number: 61036-64-4
CAS Name: Teicoplanin A2
Synonyms: teichomycin A2
Manufacturers' Codes: MDL-507
Trademarks: Targocid (Aventis); Targosid (Aventis)
Literature References: Glycopeptide antibiotic complex produced by Actinoplanes teichomyceticus nov. sp.; structurally related to vancomycin, q.v. Comprised of 5 major components differentiated by a specific fatty acid moiety. Inhibits peptidoglycan synthesis in the cell wall of gram-positive bacteria. Isoln: BE 839259; C. Coronelli et al., US 4239751 (1976, 1980 both to Lepetit); F. Parenti et al., J. Antibiot. 31, 276 (1978); M. R. Bardone et al., ibid. 170. Separation of components: A. Borghi et al., DE 3320342; eidem, US 4542018 (1983, 1985 both to Lepetit); eidem, J. Antibiot. 37, 615 (1984). Structural studies: C. Coronelli et al., ibid. 621; J. C. J. Barna et al., J. Am. Chem. Soc. 106, 4895 (1984). Comparative in vitro activity: M. H. Cynamon, P. A. Granato, Antimicrob. Agents Chemother. 21, 504 (1982); H. C. Neu, P. Labthavikul, idem, 24, 425 (1983). Human pharmacokinetics: L. Verbist et al., ibid. 26, 881 (1984); P. L. Carver et al., ibid. 33, 82 (1989). Mechanism of action: S. Somma et al., ibid. 26, 917 (1984). Synergism with rifampin, q.v.: C. Watanakunakorn, J. Antimicrob. Chemother. 19, 439 (1987). HPLC determn in human serum: J. Levy et al., ibid. 533. Clinical trial in gram-positive bacterial infections: Y. Glupczynski et al., Antimicrob. Agents Chemother. 29, 52 (1986). Brief review: A. H. Williams, R. N. Grüneberg, J. Antimicrob. Chemother. 14, 441 (1984). Symposium on chemistry, pharmacology, activity, and clinical trials: J. Hosp. Infect. 7, Suppl. A, 47-112 (1986).
Properties: Amorphous powder, mp 260° (dec). uv max in 0.1N HCl: 278 (E1%1cm 53); in 0.1N NaOH: 297 (E1%1cm 74). Sol in aq soln at pH 7.0; partially sol in methanol, ethanol. Insol in dil mineral acids, in non-polar organic solvents.
Melting point: mp 260° (dec)
Absorption maximum: uv max in 0.1N HCl: 278 (E1%1cm 53); in 0.1N NaOH: 297 (E1%1cm 74)
 
Derivative Type: Teicoplanin A2-1
CAS Registry Number: 91032-34-7
Molecular Formula: C88H95Cl2N9O33
Molecular Weight: 1877.64
Percent Composition: C 56.29%, H 5.10%, Cl 3.78%, N 6.71%, O 28.12%
Properties: White amorphous powder, darkens at 220°, dec 255°.
 
Derivative Type: Teicoplanin A2-2
CAS Registry Number: 91032-26-7
Molecular Formula: C88H97Cl2N9O33
Molecular Weight: 1879.66
Percent Composition: C 56.23%, H 5.20%, Cl 3.77%, N 6.71%, O 28.09%
Properties: White amorphous powder, darkens at 210°, dec 250°.
 
Derivative Type: Teicoplanin A2-3
CAS Registry Number: 91032-36-9
Molecular Formula: C88H97Cl2N9O33
Molecular Weight: 1879.66
Percent Composition: C 56.23%, H 5.20%, Cl 3.77%, N 6.71%, O 28.09%
Properties: White amorphous powder, darkens at 210°, dec 250°.
 
Derivative Type: Teicoplanin A2-4
CAS Registry Number: 91032-37-0
Molecular Formula: C89H99Cl2N9O33
Molecular Weight: 1893.68
Percent Composition: C 56.45%, H 5.27%, Cl 3.74%, N 6.66%, O 27.88%
Properties: White amorphous powder, darkens at 210°, dec 250°.
 
Derivative Type: Teicoplanin A2-5
CAS Registry Number: 91032-38-1
Molecular Formula: C89H99Cl2N9O33
Molecular Weight: 1893.68
Percent Composition: C 56.45%, H 5.27%, Cl 3.74%, N 6.66%, O 27.88%
Properties: White amorphous powder, darkens at 210°, dec 250°.
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); Polypeptides.