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CAS No 62304-98-7 , Thymosin alpha 1

  • Name: Thymosin alpha 1
  • Synonyms: Thymosin alpha1 (human);Zadaxin; Thymosin alpha1 (ox); 62304-98-7;Thymosin alpha 1; Thymosin alpha1 (cattle); Thymalfasin;
  • CAS Registry Number:
  • Molecular Weight: 3108.2755
  • InchiKey: NZVYCXVTEHPMHE-ZSUJOUNUSA-N
  • InChI: InChI=1S/C129H215N33O55/c1-18-59(10)98(159-114(201)76(36-42-91(181)182)
    146-120(207)83(53-164)154-121(208)84(54-165)155-127(214)99(63(14)166)
    160-118(205)80(51-94(187)188)152-123(210)95(56(4)5)156-104(191)62(13)
    135-102(189)60(11)137-115(202)78(49-92(183)184)151-119(206)82(52-163)
    138-66(17)169)125(212)161-101(65(16)168)128(215)162-100(64(15)167)126
    (213)147-70(30-22-26-46-133)109(196)150-79(50-93(185)186)117(204)149-77
    (47-55(2)3)116(203)142-69(29-21-25-45-132)108(195)144-73(33-39-88(175)
    176)110(197)141-67(27-19-23-43-130)106(193)140-68(28-20-24-44-131)107
    (194)145-75(35-41-90(179)180)113(200)157-97(58(8)9)124(211)158-96(57(6)
    7)122(209)148-74(34-40-89(177)178)111(198)143-71(31-37-86(171)172)105
    (192)136-61(12)103(190)139-72(32-38-87(173)174)112(199)153-81(129(216)
    217)48-85(134)170/h55-65,67-84,95-101,163-168H,18-54,130-133H2,1-17H3,
    (H2,134,170)(H,135,189)(H,136,192)(H,137,202)(H,138,169)(H,139,190)(H,
    140,193)(H,141,197)(H,142,203)(H,143,198)(H,144,195)(H,145,194)(H,146,
    207)(H,147,213)(H,148,209)(H,149,204)(H,150,196)(H,151,206)(H,152,
    210)(H,153,199)(H,154,208)(H,155,214)(H,156,191)(H,157,200)(H,158,
    211)(H,159,201)(H,160,205)(H,161,212)(H,162,215)(H,171,172)(H,173,
    174)(H,175,176)(H,177,178)(H,179,180)(H,181,182)(H,183,184)(H,185,
    186)(H,187,188)(H,216,217)/t59-,60-,61-,62-,63+,64+,65+,67-,68-,69-,70-,
    71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,95-,96-,97-,98-,
    99-,100-,101-/m0/s1
  • Molecular Formula: C129H215N33O55
  • Molecular Structure:CAS No:62304-98-7 Thymosin alpha 1
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62304-98-7 Thymosin α1

  • Product name Thymosin α1 CAS No 62304-98-7 Sequence Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH Molecular Formula C129H215N33O55 Molecular Weight 3108.28 Appearance White to o...
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62304-98-7 Thymosin |á1 Acetate

  • Product Name Thymosin |á1 Acetate Sequence Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu- Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys- Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH Cas No. 62304-98-7 Molecular Formula C129H215N33O55 Molecular Weight 3108.3 Purity (HPL...
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62304-98-7 Thymosin α1 Acetate

  • Thymosin α1 Acetate Cas No.: 62304-98-7 Cas No.: 62304-98-7 Molecular Formula: C129H215N33O55 Molecular Weight: 3108.3 Purity (HPLC): 98.0%min. Appearance: White powder Single Impurity (HPLC): 1.0%max Amino Acid Composition: ±10% of theoretical Pept...
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  • 62304-98-7 Thymosin α1 Acetate

    • Thymosin α1 Acetate Cas No.: 62304-98-7 Cas No.: 62304-98-7 Molecular Formula: C129H215N33O55 Molecular Weight: 3108.3 Purity (HPLC): 98.0%min. Appearance: White powder Single Impurity (HPLC): 1.0%max Amino Acid Composition: ±10% of theoretical Pept...
    • Min. Order: 10
    • FOB Price: USD1 - 1 /
    • China Raw Steroid Main Shop [Manufacturer]
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    62304-98-7 Thymosin α1 Acetate

    • Thymosin α1 Acetate Sequence Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu- Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys- Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH Cas No. 62304-98-7 Molecular Formula C129H215N33O55 Molecular Weight 3108.3 Purity (HPLC) 98.0%min. ...
    • Min. Order: 1000
    • FOB Price: USD1 - 2 /
    • China Hubei Yuancheng Saichuang Technology Co.,Ltd. [Manufacturer]
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    62304-98-7 China High purity polypeptide Thymosin α1 Acetate

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    • China Wuhan Yuancheng Group [Manufacturer]
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    62304-98-7 Thymosin α1 Acetate

    • Thymosin α1 Acetate Sequence :Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu- Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys- Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH Cas No.:62304-98-7 Molecular Formula:C129H215N33O55 Molecular Weight:3108.3 Purity (HPLC):98.0%min ...
    • Min. Order: 500
    • China Hubei Yuancheng Group [Manufacturer, Trading Company]
    • Tel: 86-027-50756063
    • Address: Zhongshan Road Wuhan,HubeiChina
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    62304-98-7 Thymosin α1 Acetate

    • Thymosin α1 Acetate Sequence :Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu- Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys- Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH Cas No.:62304-98-7 Molecular Formula:C129H215N33O55 Molecular Weight:3108.3 Purity (HPLC):98.0%min ...
    • Min. Order: 500
    • China Hubei Yuancheng Group [Manufacturer]
    • Tel: 86-027-50756063
    • Address: Zhongshan Road Wuhan,HubeiChina
    Contact Supplier

    62304-98-7 Thymosin α1 Acetate

    • Thymosin α1 Acetate Sequence :Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu- Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys- Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH Cas No.:62304-98-7 Molecular Formula:C129H215N33O55 Molecular Weight:3108.3 Purity (HPLC):98.0%min ...
    • Min. Order: 500
    • China Wuhan Yuancheng Group [Manufacturer, Trading Company]
    • Tel: 86-027-50756153
    • Address: Zhongshan Road Wuhan,HubeiChina
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    62304-98-7 Thymosin α1 Acetate

    • Thymosin α1 Acetate Sequence :Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu- Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys- Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH Cas No.:62304-98-7 Molecular Formula:C129H215N33O55 Molecular Weight:3108.3 Purity (HPLC):98.0%min ...
    • Min. Order: 500
    • China Hubei Saichuang Group [Manufacturer, Trading Company]
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    References of Thymosin alpha 1
    Title: Thymosins
    Literature References: Family of thymic peptide hormones that regulate immune and endocrine events. Extraction from calf thymus and partial purification: A. L. Goldstein et al., Proc. Natl. Acad. Sci. USA 56, 1010 (1966). Purification and characterization of thymosins and isoln of one of the active components, thymosin fraction 5: eidem, ibid. 69, 1800 (1972). Improved isoln and properties: J. A. Hooper et al., Ann. N.Y. Acad. Sci. 249, 125 (1975). Thymosin fraction 5 is a mixture of polypeptides ranging in mol wt from ~1000 to 15,000; it has a very low content of non-protein material; it is heat stable up to 80°. It is an immunopotentiating agent that can act in place of the thymus gland in immuno-deprived or thymus-deprived patients to restore some immune functions. Nomenclature of the polypeptide fragments of fraction 5 is based on isoelectric points: a-region below 5.0, b-region 5.0-7.0, and g-region above 7.0. Thymosin a1 is an acidic (pI 4.2), 28 amino acid polypeptide (mol wt 3108) found in the highly acidic region of fraction 5. It is a biologically active proteolytic fragment of prothymosin a1. Isoln and preliminary structural determination of thymosin a1: A. L. Goldstein et al., Proc. Natl. Acad. Sci. USA 74, 725 (1977). Isoln, characterization, biological activities, and amino acid sequence analysis of a1 and polypeptide b1, a 74 amino acid peptide identical with ubiquitin, q.v.: T. L. K. Low et al., J. Biol. Chem. 254, 981 (1979); T. L. K. Low, A. L. Goldstein, ibid. 987. Synthesis of a1 by solution methods: S. S. Wang et al., J. Am. Chem. Soc. 101, 253 (1979). Thymosin b4 is a biologically active, G-actin sequestering peptide consisting of 43 amino acids; mol wt 4.9 kDa; pI 5.1. Amino acid sequence of b4: T. L. K. Low et al., Proc. Natl. Acad. Sci. USA 78, 1162 (1981). Automated solid phase synthesis of b4: S. S. Wang et al., Int. J. Pept. Protein Res. 18, 413 (1981). Role of b4 in wound healing: K. M. Malinda et al., J. Invest. Dermatol. 113, 364 (1999). Series of articles on prepn, purification and characterization of thymic hormones and peptides: Methods Enzymol. 116, 213-291 (1985). Review of immune and endocrine modulation: P. H. Naylor, A. L. Goldstein, Adv. Pigment Cell Res. 256, 489-502 (1988); of immunological activities and therapeutic uses of thymic hormones and factors: S. Ben-Efraim et al., Crit. Rev. Immunol. 19, 261-284 (1999); of b-thymosins: V. T. Nachmias, Curr. Opin. Cell Biol. 5, 56-62 (1993); T. Huff et al., Int. J. Biochem. Cell Biol. 33, 205-220 (2001).
     
    Derivative Type: Thymalfasin
    CAS Registry Number: 62304-98-7
    Synonyms: Human thymosin a1; bovine thymosin a1
    Trademarks: Zadaxin (SciClone); Timosina (Sclavo)
    Literature References: Synthetic peptide; mol wt 3108. Synthesis: S. S. Wang et al., Int. J. Pept. Protein Res. 15, 1 (1980). Clinical trial in influenza vaccine enhancement: S. Gravenstein et al., J. Am. Geriatr. Soc. 37, 1 (1989). Clinical pharmacokinetics: K. L. Rost et al., Int. J. Clin. Pharmacol. Ther. 37, 51 (1999). Review of use in combined chemo-immunotherapy in treatment of cancer: E. Garaci et al., Int. J. Immunopharmacol. 22, 1067-1076 (2000); of clinical efficacy in hepatitis: P. H. Naylor, Expert Opin. Invest. Drugs 8, 281-287 (1999); A. Billich, Curr. Opin. Invest. Drugs 3, 698-707 (2002).
    Properties: pI 3.8.
     
    Therap-Cat: Thymalfasin as immunomodulator.