Home > Name List By other > (6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7, 8-tetrahydro-1H-pteridin-4-one

CAS No 62989-33-7 , (6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,
8-tetrahydro-1H-pteridin-4-one

  • Name: (6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,
    8-tetrahydro-1H-pteridin-4-one
  • Synonyms: L-erythro-tetrahydrobiopterin; Sapropterinum; 6R-5,6,7,8-Tetrahydrobiopterin;(6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,
    8-tetrahydro-1H-pteridin-4-one; Sapropterina; Sapropterin;tetrahydrobiopterin; 6R-L-5,6,7,8-Tetrahydrobiopterin;
  • CAS Registry Number:
  • Density: 1.89g/cm3
  • Refractive index: 1.822
  • Hazard Symbols: Xn
  • Molecular Weight: 241.2471
  • InchiKey: FNKQXYHWGSIFBK-RPDRRWSUSA-N
  • InChI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,
    6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17)/t3-,4+,6-/m0/s1
  • Risk Statements: 22
  • Molecular Formula: C9H15N5O3
  • Molecular Structure:CAS No:62989-33-7 (6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,<br />8-tetrahydro-1H-pteridin-4-one

Related products

Search by region :

Select to

62989-33-7 Sapropterin

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 null,nullUnited States
Contact Supplier

62989-33-7 Sapropterin

  • China Shanghai Richem International Co., Ltd. null
  • Tel: +86-(21)-31263688
  • Fax: +86-(21)-51862199
  • Address: Room 603, Golden Eagle Mansion A, No.1518 Minsheng Road, Pudong, Shanghai 200135, shanghai,shanghaiChina
Contact Supplier

62989-33-7 (6R,S)-5,6,7,8-TETRAHYDRO-L-BIOPTERIN DIHYDROCHLORIDE

  • China SHANGHAI RICHEM INTERNATIONAL CO., LTD. [Manufacturer]
  • Tel: +86-21-31263688
  • Fax: +86-21-51862199
  • Address: Room 603, Golden Eagle Mansion A,
    No.1518 Minsheng Road, Pudong,
    Shanghai (200135), P.R.China null,nullChina
Contact Supplier

62989-33-7 SAPROPTERIN

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China null,nullChina
Contact Supplier

Select to

1/1
References of (6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,
8-tetrahydro-1H-pteridin-4-one
Title: Sapropterin
CAS Registry Number: 62989-33-7
CAS Name: (6R)-2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydro-4(1H)-pteridinone
Synonyms: (6R)-L-erythro-tetrahydrobiopterin; dapropterin; R-THBP; 6R-BH4
Molecular Formula: C9H15N5O3
Molecular Weight: 241.25
Percent Composition: C 44.81%, H 6.27%, N 29.03%, O 19.90%
Literature References: Natural cofactor of the aromatic amino acid hydroxylases required for catecholamine and serotonin biosynthesis. Identification of cofactor activity: S. Kaufman, Proc. Natl. Acad. Sci. USA 50, 1085 (1963). Prepn of (6R,S)-BH4: B. Schircks et al., Helv. Chim. Acta 61, 2731 (1978). Chromatographic separation of diastereoisomers: S. W. Bailey, J. E. Ayling, J. Biol. Chem. 253, 1598 (1978). Absolute configuration of natural isomer: W. L. F. Armarego et al., Aust. J. Chem. 35, 785 (1982). Stereospecific synthesis: S. Matsuura et al., Heterocycles 23, 3115 (1985); H. Sakai, T. Kanai, EP 191335; eidem, US 4713454 (1986, 1987 both to Shiratori; Suntory). Bioavailability: G. Kapatos, S. Kaufman, Science 212, 955 (1981). Effect on neurotransmitter monoamine biosynthesis: S. Miwa et al., Arch. Biochem. Biophys. 239, 234 (1985). LC determn in biological samples: Y. Tani, T. Ishihara, Life Sci. 46, 373 (1990). Therapeutic potential in hyperphenylalaninemia: S. Kaufman, J. Nutr. Sci. Vitaminol, Suppl., 601 (1992).
Properties: pK￠ 5.05. uv max (0.1 N HCl): 265 nm (e 14000).
pKa: pK￠ 5.05
Absorption maximum: uv max (0.1 N HCl): 265 nm (e 14000)
 
Derivative Type: Dihydrochloride
CAS Registry Number: 69056-38-8
Manufacturers' Codes: SUN-0588
Trademarks: Biopten (Maruho)
Molecular Formula: C9H15N5O3.2HCl
Molecular Weight: 314.17
Percent Composition: C 34.41%, H 5.45%, N 22.29%, O 15.28%, Cl 22.57%
Properties: Crystals from HCl, mp 245-246° (dec). [a]D25 -6.81° (c = 0.665 in 0.1 M HCl). uv max (2 M HCl): 264 nm (e 16770).
Melting point: mp 245-246° (dec)
Optical Rotation: [a]D25 -6.81° (c = 0.665 in 0.1 M HCl)
Absorption maximum: uv max (2 M HCl): 264 nm (e 16770)
 
Therap-Cat: In treatment of hyperphenylalaninemia.
Keywords: Enzyme Cofactor.