Home > Name List By n > N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1, 2-diamine

CAS No 63-56-9 , N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,
2-diamine

  • Name: N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,
    2-diamine
  • Synonyms: Neohetramine hydrochloride; Novohetramin; Thonzylaminium chloride; Resistab;THONZYLAMINE HYDROCHLORIDE;hydrochloride; CCRIS 6277;N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,
    2-diamine; Anahist;
  • CAS Registry Number:
  • Melting Point: 173 - 176 C
  • Flash Point: 220.3°C
  • Boiling Point:
    Vapour density:
  • Safety Statements: Poison by ingestion, intravenous, and intraperitoneal routes. Used as an antihistamine. When heated to decomposition it emits very toxic fumes of HCl and NOx.
  • Flash Point: 220.3°C
  • EINECS: 200-561-3
  • Molecular Weight: 322.83302
  • InchiKey: HRYJPHOTGFERGT-UHFFFAOYSA-N
  • InChI: InChI=1S/C16H22N4O.ClH/c1-19(2)11-12-20(16-17-9-4-10-18-16)13-14-5-7-15
    (21-3)8-6-14;/h4-10H,11-13H2,1-3H3;1H
  • Molecular Formula: C16H23ClN4O
  • Molecular Structure:CAS No:63-56-9 N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,<br />2-diamine

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References of N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,
2-diamine
Title: Thonzylamine Hydrochloride
CAS Registry Number: 63-56-9
CAS Name: N-[(4-Methoxyphenyl)methyl]-N￠,N￠-dimethyl-N-2-pyrimidinyl-1,2-ethanediamine monohydrochloride
Synonyms: 2-[(2-dimethylaminoethyl)(p-methoxybenzyl)amino]pyrimidine hydrochloride; N,N-dimethyl-N￠-(p-methoxybenzyl)-N￠-(2-pyrimidyl)ethylenediamine hydrochloride
Trademarks: Anahist (Warner-Lambert); Tonamil (Ecobi)
Molecular Formula: C16H23ClN4O
Molecular Weight: 322.83
Percent Composition: C 59.53%, H 7.18%, Cl 10.98%, N 17.35%, O 4.96%
Literature References: Histamine H1-receptor antagonist. Prepd by treating the sodium salt of 2-(p-methoxybenzyl)aminopyrimidine with N,N-dimethyl-2-chloroethylamine: Friedman, Tolstoouhov, US 2465865 (1949). Toxicity study: Reinhard, Seudi, Proc. Soc. Exp. Biol. Med. 66, 512 (1947). Spectroscopic determn in nasal drops: S. M. Sabry et al., J. Pharm. Biomed. Anal. 22, 257 (2000).
Properties: Crystals, mp 173-176° (free base, oily liq, bp2.2 185-187°). Freely sol in water; sol in alcohol, chloroform. Practically insol in ether. pH 5.1-5.7 (2% aq solution). LD50 orally in guinea pigs: 493 mg (base)/kg (Reinhard, Seudi).
Melting point: mp 173-176°
Boiling point: bp2.2 185-187°
Toxicity data: LD50 orally in guinea pigs: 493 mg (base)/kg (Reinhard, Seudi)
Therap-Cat: Antihistaminic.
Keywords: Antihistaminic; Ethylenediamine Derivatives.