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CAS No 637-07-0 , ethyl 2-(4-chlorophenoxy)-2-methylpropanoate

  • Name: ethyl 2-(4-chlorophenoxy)-2-methylpropanoate
  • Synonyms: Atromid; Antilipide; Anparton; Antilipid; Ethyl clofibrate; Arterosol; Atromid-S; Angiokapsul; Arterioflexin;ethyl 2-(4-chlorophenoxy)-2-methylpropanoate;
  • CAS Registry Number:
  • Transport: UN 3082 9/PG 3
  • Flash Point: 113 °C
  • Boiling Point: 154-156 ºC
  • Density: 1.137
  • Refractive index: 1.503
  • Water Solubility: Soluble to 100 mM in DMSO
  • Safety Statements: R22;R40
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 113 °C
  • EINECS: 211-277-4
  • Molecular Weight: 242.6987
  • InchiKey: KNHUKKLJHYUCFP-UHFFFAOYSA-N
  • InChI: InChI=1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,
    4H2,1-3H3
  • Risk Statements: S36/37;S45
  • Molecular Formula: C12H15ClO3
  • Molecular Structure:CAS No:637-07-0 ethyl 2-(4-chlorophenoxy)-2-methylpropanoate

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References of ethyl 2-(4-chlorophenoxy)-2-methylpropanoate
Title: Clofibrate
CAS Registry Number: 637-07-0
CAS Name: 2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl ester
Synonyms: ethyl 2-(p-chlorophenoxy)-2-methylpropionate; ethyl p-chlorophenoxyisobutyrate
Trademarks: Amotril; Anparton (Sanwa); Apolan (Stockli); Artevil; Ateculon (Nippon Chemiphar); Ateriosan; Atheropront (Mack, Illert.); Atromidin; Atromid-S (Ayerst); Bioscleran (Pfleger); Claripex (Usafarma); Clobren-SF (Morishita); Clofinit (Gentili); CPIB; Hyclorate (Funai); Liprinal (BMS); Neo-Atromid; Normet (Gedeon Richter); Normolipol (Delagrange); Recolip (Benzon); Regelan (Zeneca); Serotinex; Sklerolip (Mepha); Skleromexe (L. Merckle); Sklero-Tablinen (Sanorania); Xyduril (Dorsch)
Molecular Formula: C12H15ClO3
Molecular Weight: 242.70
Percent Composition: C 59.39%, H 6.23%, Cl 14.61%, O 19.78%
Literature References: Prepn: W. G. M. Jones et al., GB 860303; eidem, US 3262850 (1961, 1966 both to I.C.I.). Clinical trials in the primary prevention of ischaemic heart disease: Br. Heart J. 40, 1069 (1978); Lancet 2, 379 (1980). Toxicity data: G. Metz et al., Arzneim.-Forsch. 27, 1173 (1977). Review of pharmacology: M. Chevais, Therapie 35, 5-22 (1980); of metabolism: M. N. Cayen, Rev. Drug Metab. Drug Interact. 3, 77-103 (1980); of toxicity studies: IARC Monographs 24, 39-58 (1980). Comprehensive description: M. M. A. Hassan, A. A. Elazzouny, Anal. Profiles Drug Subs. 11, 197-224 (1982).
Properties: Oil, bp20 148-150°. Practically insol in water. Misc with ethanol, acetone, chloroform, ether. LD50 in mice, rats (g/kg): 1.28, 1.65 orally (Metz).
Boiling point: bp20 148-150°
Toxicity data: LD50 in mice, rats (g/kg): 1.28, 1.65 orally (Metz)
 
Derivative Type: Mixture with androsterone
CAS Registry Number: 8075-95-4
Trademarks: Atromid (Ayerst)
 
Therap-Cat: Antilipemic.
Keywords: Antilipemic; Fibrates.