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CAS No 64211-46-7 , Oxiconazole nitrate

  • Name: Oxiconazole nitrate
  • Synonyms: (Z)-1-[2-(2,4-Dichlorophenyl)-2-[[(2,4-dichlorophenyl)oxy]imino]ethyl]-1H-imidazole mononitrate;Oxiconazole nitrate;
  • CAS Registry Number:
  • Melting Point: 137-1380C
  • Flash Point: 302.6 ºC
  • Boiling Point: 576.8 ºC
  • Flash Point: 302.6 ºC
  • EINECS: 264-730-3
  • Molecular Weight: 492.14
  • InChI: InChI=1/C18H13Cl4N3O.HNO3/c19-13-2-1-12(16(21)7-13)10-26-24-18(9-25-6-5-23-11-25)15-4-3-14(20)8-17(15)22;2-1(3)4/h1-8,11H,9-10H2;(H,2,3,4)/b24-18+;
  • Molecular Formula: C18H13Cl4N3O.HNO3
  • Molecular Structure:CAS No:64211-46-7 Oxiconazole nitrate

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References of Oxiconazole nitrate
Title: Oxiconazole Nitrate
CAS Registry Number: 64211-46-7
CAS Name: (Z)-1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanone O-[(2,4-dichlorophenyl)methyl]oxime mononitrate
Synonyms: 2￠,4￠-dichloro-2-(imidazol-1-yl)acetophenone O-(2,4-dichlorobenzyl)oxime nitrate
Manufacturers' Codes: Sgd-301-76; Ro-13-8996
Trademarks: Gyno-Myfungar (Klinge); Myfungar (Wyeth); Oceral (Roche); Oxistat (GSK)
Molecular Formula: C18H14Cl4N4O4
Molecular Weight: 492.14
Percent Composition: C 43.93%, H 2.87%, Cl 28.82%, N 11.38%, O 13.00%
Literature References: Broad spectrum topical antimycotic agent. Prepn: G. Mixich et al., DE 2657578; eidem, US 4124767 (1977, 1978 both to Siegfried). Stereospecific synthesis of (E)-, (Z)-isomers, 1H NMR study: G. Mixich, K. Thiele, Arzneim.-Forsch. 29, 1510 (1979). GLC determn in plasma: M. Zell, L. Herzfeld, J. Chromatogr. 229, 111 (1982). In vitro and in vivo antifungal activity: A. Polak, Arzneim.-Forsch. 32, 17 (1982). Study of skin, nail penetration: G. Stueltgen, E. Bauer, Mykosen 25, 74 (1982). Comparison of antifungal imidazoles: W. H. Beggs, IRCS Med. Sci. 11, 677 (1983).
Properties: Crystals from ethanol, mp 137-138°.
Melting point: mp 137-138°
Therap-Cat: Antifungal.
Keywords: Antifungal (Synthetic); Imidazoles.