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CAS No 64241-34-5 , ethyl N-[[6-[ethyl(2-hydroxypropyl)amino]pyridazin-3-yl]amino]carbamate

  • Name: ethyl N-[[6-[ethyl(2-hydroxypropyl)amino]pyridazin-3-yl]amino]carbamate
  • Synonyms: Cadralazina [INN-Spanish]; NCGC00182063-02;Cadralazina [Spanish]; Cadralazinum [INN-Latin]; BRN 0894631; 64241-34-5; ISF 2469;ethyl N-[[6-[ethyl(2-hydroxypropyl)amino]pyridazin-3-yl]amino]carbamate; DC-826;
  • CAS Registry Number:
  • Density: 1.253 g/cm3
  • Refractive index: 1.59
  • Safety Statements: Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
  • Molecular Weight: 283.32684
  • InchiKey: QLTVVOATEHFXLT-UHFFFAOYSA-N
  • InChI: InChI=1S/C12H21N5O3/c1-4-17(8-9(3)18)11-7-6-10(13-15-11)14-16-12(19)20-
    5-2/h6-7,9,18H,4-5,8H2,1-3H3,(H,13,14)(H,16,19)
  • Molecular Formula: C12H21N5O3
  • Molecular Structure:CAS No:64241-34-5 ethyl N-[[6-[ethyl(2-hydroxypropyl)amino]pyridazin-3-yl]amino]carbamate
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64241-34-5 CADRALAZINE

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
    17 Walnut St., Tai Kok Tsui, Kln,
    Hong Kong null,nullHong kong
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64241-34-5 Cadralazine

  • Cadralazine, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,nullChina
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64241-34-5 Cadralazine

  • Cadralazine, 99%
  • China Facus Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-(0)574-62378411
  • Fax: +86-(0)574-62378410
  • Address: 24Fl,Yuanjing Building,Beilun District, Zhejiang 315800 NingboCHINA Ningbo,nullChina
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64241-34-5 Cadralazine

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 null,nullUnited States
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64241-34-5 Cadralazine

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64241-34-5 Hydrazinecarboxylicacid, 2-[6-[ethyl(2-hydroxypropyl)amino]-3-pyridazinyl]-, ethyl ester

  • United States Waterstone Technology LLC [Manufacturer]
  • Tel: 317-644-0862/ 317-218-7464
  • Fax: 317-569-8068
  • Address: Waterstone Technology LLC
    12202 Hancock Street
    Carmel, IN. 46032 null,nullUnited States
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64241-34-5 Cadralazine, 99%

  • Cadralazine, 99%
  • China Pleapharma Co.,Ltd [Manufacturer]
  • Tel: 86 23 67030808
  • Fax: 86 23 67030809
  • Address: 22F,Jingxin center,No.70 Xingguang Road,Yubei Zone,Chongqing402232 chongqingCHINA chongqing,nullChina
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64241-34-5 Cadralazine

  • Cadralazine, 99%
  • China Tianjin Pharmacn Science Co., Ltd. [Manufacturer]
  • Tel: 86-22-23359620/ 86-13612042162 (mobile)
  • Fax: 86-22-23359620
  • Address: 1006 Sinochem Building, 707 Lianmeng RD, Shijiazhuang 050061, Hebei, China null,nullChina
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64241-34-5 Cadralazine

  • Cadralazine
  • China Hallopharma [Manufacturer]
  • Tel: 0086-23-67030808
  • Fax: 0086-23-67030818
  • Address: 17F,Venus Science Incubate Center,No.60 Xingguang Road,New North Zone,401121 ChongqingCHINA Chongqing,nullChina
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64241-34-5 Cadralazine

  • Cadralazine
  • China Inter-Chemical [Manufacturer]
  • Tel: 0086-23-67030808
  • Fax: 0086-23-67030818
  • Address: 17F,Venus Science Incubate Center,No.60 Xingguang Road,New North Zone,401121 ChongqingCHINA Chongqing,nullChina
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References of ethyl N-[[6-[ethyl(2-hydroxypropyl)amino]pyridazin-3-yl]amino]carbamate
Title: Cadralazine
CAS Registry Number: 64241-34-5
CAS Name: 2-[6-[Ethyl(2-hydroxypropyl)amino]-3-pyridazinyl]hydrazinecarboxylic acid ethyl ester
Synonyms: ethyl 6-[ethyl(2-hydroxypropyl)amino]-3-pyridazinecarbazate; 3-(2-carbethoxyhydrazino)-6-[N-(2-hydroxypropyl)ethylamino]pyridazine
Manufacturers' Codes: DC-826; ISF-2469
Trademarks: Cadral (Novartis); Cadraten (ISF); Cadrilan (Novartis); Presmode (Sankyo)
Molecular Formula: C12H21N5O3
Molecular Weight: 283.33
Percent Composition: C 50.87%, H 7.47%, N 24.72%, O 16.94%
Literature References: Peripheral vasodilator similar to hydralazine, q.v. Prepn: C. Carpi et al., BE 811847; eidem, US 3925381; US 4002753 (1974, 1975, 1977 all to ISF); F. Parravicini et al., Farmaco Ed. Sci. 34, 299 (1979). Analytical profile: L. Citerio et al., Boll. Chim. Farm. 120, 222 (1981). Pharmacology: C. Semeraro et al., J. Cardiovasc. Pharmacol. 3, 455 (1981). HPLC determn in plasma and urine: T. Crolla et al., J. Chromatogr. 310, 139 (1984). Hemodynamic effects in dogs: L. Dorigotti et al., Arzneim.-Forsch. 34, 984 (1984); in humans: B. Persson et al., Eur. J. Clin. Pharmacol. 31, 513 (1987). Pharmacokinetics and metabolism in humans: H. Schütz et al., Eur. J. Drug Metab. Pharmacokinet. 10, 147 (1985); S. A. Hauffe et al., ibid. 217. Preliminary clinical evaluations: R. Buoninconti, M. Motolese, Int. J. Clin. Pharmacol. Ther. Toxicol. 23, 613 (1985); A. Salvadeo et al., Arzneim.-Forsch. 35, 623 (1985).
Properties: Crystals from acetone, mp 160-162°. pKa 6.0. uv max: 248, 340 nm (e 22100, 2250). Soly (mg/ml): water 1.3; HCl 235.0; DMSO 323.0; methanol 21.0; dioxane 18.6; chloroform 8.5; diethyl ether, benzene, cyclohexane <0.1. LD50 in rats, dogs (mg/kg): 269, approx 400 i.v.; 2060, >2000 orally (Semeraro); in mice (mg/kg): 700 i.p. (Parravicini).
Melting point: mp 160-162°
pKa: pKa 6.0
Absorption maximum: uv max: 248, 340 nm (e 22100, 2250)
Toxicity data: LD50 in rats, dogs (mg/kg): 269, approx 400 i.v.; 2060, >2000 orally (Semeraro); in mice (mg/kg): 700 i.p. (Parravicini)
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive; Hydrazines/Phthalazines.