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CAS No 6493-05-6 , 3,7-dimethyl-1-(5-oxohexyl)purine-2,6-dione Search by region : Switzerland

  • Name: 3,7-dimethyl-1-(5-oxohexyl)purine-2,6-dione
  • Synonyms: Pentoxyfylline; Pentoxil; Pentoxifyllin;3,7-dimethyl-1-(5-oxohexyl)purine-2,6-dione; Vazofirin;Trental; Pentoxyphylline; Pentoxiphyllium; Oxpentifylline; Torental;
  • CAS Registry Number:
  • Flash Point: 275.1°C
  • Boiling Point: 531.3°Cat760mmHg
  • Density: 1.31g/cm3
  • Safety Statements: Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. Human systemic effects by ingestion: pulse rate decrease with fall in blood pressure. Human mutation data reported. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
  • Hazard Symbols: Xn
  • Flash Point: 275.1°C
  • EINECS: 229-374-5
  • Molecular Weight: 278.30702
  • InchiKey: BYPFEZZEUUWMEJ-UHFFFAOYSA-N
  • InChI: InChI=1S/C13H18N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13
    (17)20/h8H,4-7H2,1-3H3
  • Risk Statements: 22
  • Molecular Formula: C13H18N4O3
  • Molecular Structure:CAS No:6493-05-6 3,7-dimethyl-1-(5-oxohexyl)purine-2,6-dione

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6493-05-6 PENTOXIFYLLINE

  • Switzerland BIOTREND Chemicals AG [Manufacturer]
  • Tel: +41 44 805 76 76
  • Fax: +41 44 805 76 77
  • Address: BIOTREND Chemicals AG
    Unterdorfstr. 21b
    CH-8602 Wangen/Zuerich
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References of 3,7-dimethyl-1-(5-oxohexyl)purine-2,6-dione
Title: Pentoxifylline
CAS Registry Number: 6493-05-6
CAS Name: 3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione
Synonyms: 1-(5-oxohexyl)theobromine; 1-(5-oxohexyl)-3,7-dimethylxanthine; 3,7-dimethyl-1-(5-oxohexyl)-1H,3H-purin-2,6-dione; oxpentifylline; vazofirin
Manufacturers' Codes: BL-191
Trademarks: Azupentat (Azupharma); Durapental (Durachemie); Rentylin (Rentschler); Torental (Aventis); Trental (Aventis)
Molecular Formula: C13H18N4O3
Molecular Weight: 278.31
Percent Composition: C 56.10%, H 6.52%, N 20.13%, O 17.25%
Literature References: Methylxanthine derivative that improves blood flow by decreasing blood viscosity. Identity as a metabolite of pentifylline, q.v.: Mohler et al., Arch. Pharm. 299, 448 (1966); Mohler et al., Arzneim.-Forsch. 16, 1524 (1966). Prepn: NL 6511581; Mohler et al., DE 1235320; eidem, US 3422107 (1966, 1967, 1969 all to Chem. Werke Albert). Series of articles on chemistry, pharmacology and clinical trials: Arzneim.-Forsch. 21, 1159-1177 (1971). Toxicity data: K. Popendiker et al., ibid. 1160. Review of hemorheologic properties and use in cerebrovascular disease: R. Müller, F. Lehrach, Curr. Med. Res. Opin. 7, 253-263 (1981); of pharmacology and therapeutic uses: A. Ward, S. P. Clissold, Drugs 34, 50-97 (1987); C. P. Samlaska, E. A. Winfield, J. Am. Acad. Dermatol. 30, 603-621 (1994).
Properties: Bitter tasting, colorless needles from methanol, mp 105°. uv max: 273, 208 nm (E1%1cm 365, 935). Soly in water: 77 mg/ml at 25°, 191 mg/ml at 37°; in benzene: 11 g/100 ml. LD50 orally in mice: 1385 mg/kg (Popendiker).
Melting point: mp 105°
Absorption maximum: uv max: 273, 208 nm (E1%1cm 365, 935)
Toxicity data: LD50 orally in mice: 1385 mg/kg (Popendiker)
Therap-Cat: Hemorheologic agent.
Keywords: Hemorheologic Agent.