Home > Name List By other > (2E,4E,6E,8E)-N-(4-hydroxyphenyl)-3,7-dimethyl-9-(2,6, 6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenamide China

CAS No 65646-68-6 , (2E,4E,6E,8E)-N-(4-hydroxyphenyl)-3,7-dimethyl-9-(2,6,
6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenamide Search by region : China

  • Name: (2E,4E,6E,8E)-N-(4-hydroxyphenyl)-3,7-dimethyl-9-(2,6,
    6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenamide
  • Synonyms: (2E,4E,6E,8E)-N-(4-hydroxyphenyl)-3,7-dimethyl-9-(2,6,
    6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenamide; 4-HPR; 65646-68-6; McN-R-1967; N-(4-Hydroxyphenyl)retinamide; Retinoic acid p-hydroxyanilide;4-hydroxyphenylretinamide;
  • CAS Registry Number:
  • Flash Point: 315.2 ºC
  • Boiling Point: 597.6 ºC at 760 mmHg
  • Density: 1.081 g/cm3
  • Refractive index: 1.607
  • Water Solubility: Soluble to 100 mM in Ethanol and to 100 mM in DMSO
  • Safety Statements: R60;R61;R20/21/22;R36/37/38
  • Hazard Symbols: T: Toxic;
  • Flash Point: 315.2 ºC
  • Molecular Weight: 391.54572
  • InchiKey: AKJHMTWEGVYYSE-FXILSDISSA-N
  • InChI: InChI=1S/C26H33NO2/c1-19(11-16-24-21(3)10-7-17-26(24,
    4)5)8-6-9-20(2)18-25(29)27-22-12-14-23(28)15-13-22/h6,8-9,11-16,18,28H,
    7,10,17H2,1-5H3,(H,27,29)/b9-6+,16-11+,19-8+,20-18+
  • Risk Statements: S52;S26;S36/37/39;S45
  • Molecular Formula: C26H33NO2
  • Molecular Structure:CAS No:65646-68-6 (2E,4E,6E,8E)-N-(4-hydroxyphenyl)-3,7-dimethyl-9-(2,6,<br />6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenamide

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References of (2E,4E,6E,8E)-N-(4-hydroxyphenyl)-3,7-dimethyl-9-(2,6,
6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenamide
Title: Fenretinide
CAS Registry Number: 65646-68-6
CAS Name: N-(4-Hydroxyphenyl)retinamide
Synonyms: 4-HPR; all-trans-N-4￠-hydroxyretinanilide; 4-(all-trans-retinoyl)aminophenol
Manufacturers' Codes: McN-R-1967
Molecular Formula: C26H33NO2
Molecular Weight: 391.55
Percent Composition: C 79.75%, H 8.49%, N 3.58%, O 8.17%
Literature References: Synthetic analog of vitamin A, q.v. Prepn: R. J. Gander, J. A. Gurney, BE 847942; eidem, US 4190594 (1977, 1980 both to J & J); and pharmacology: R. C. Moon et al., Cancer Res. 39, 1339 (1979). Large scale prepn and physical properties: Y. F. Shealy et al., J. Pharm. Sci. 73, 745 (1984). Clinical efficacy and safety in bladder cancer: A. Decensi et al., Eur. J. Cancer Prev. 3, 377 (1994). Review of pharmacology and clinical evaluation in breast cancer prevention: idem et al., Oncol. Rep. 1, 817-824 (1994); M. A. Cobleigh, Leukemia 8, Suppl. 3, s59-s63 (1994); and oral leukoplakia: A. Costa et al., Cancer Res. 54, Suppl., 2032s-2037s (1994).
Properties: Crystallizes in several polymorphic or solvated forms. Crystals from ethanol/water, mp 173-175° (Shealy). Crystals from chloroform/hexanes, mp 162-163°; solvated form obtained by slow crystallization from methanol, mp 178-181° (Moon). uv max (chloroform): 370 nm (e 44500). uv max (methanol): 362 nm (47900).
Melting point: mp 173-175° (Shealy); mp 162-163°; mp 178-181° (Moon)
Absorption maximum: uv max (chloroform): 370 nm (e 44500); uv max (methanol): 362 nm (47900)
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Retinoids and Analogs.