Home > Name List By 2 > 2,6-dichloro-1-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine

CAS No 66711-21-5 , 2,6-dichloro-1-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine

  • Name: 2,6-dichloro-1-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine
  • Synonyms: p-aminoclonidine; Apraclonidina;Iopidine;2,6-dichloro-1-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine; Apraclonidinum [INN-Latin]; 4-Aminoclonidine; Apraclonidinum; Aplonidine;
  • CAS Registry Number:
  • Transport: UN 2811 6.1/PG 1
  • Flash Point: 193°C
  • Boiling Point: 395.5°Cat760mmHg
  • Density: 1.63g/cm3
  • Safety Statements: S22;S36/37/39;S45;
  • Hazard Symbols: T
  • Flash Point: 193°C
  • Molecular Weight: 245.1085
  • InchiKey: IEJXVRYNEISIKR-UHFFFAOYSA-N
  • InChI: InChI=1S/C9H10Cl2N4/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9/h3-4H,1-2,
    12H2,(H2,13,14,15)
  • Risk Statements: 23/24/25
  • Molecular Formula: C9H10Cl2N4
  • Molecular Structure:CAS No:66711-21-5 2,6-dichloro-1-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine
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66711-21-5 Apraclonidine HCL

  • Apraclonidine HCL2,6-dichloro-N- (4,5-dihydro-1H-imidazol-2-yl) benzene-1,4-diamine HCL, 99.0%Min
  • China Zeniview Chemistry Technology Co., Ltd. [Manufacturer]
  • Tel: +86-25-86088590
  • Fax: +86-25-85612276
  • Address: No.05,No.01 Hangzhongmen Dajie, Nanjing, China 210016 Nanjing CHINA 210016 NanjingCHINA Nanjing,China
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66711-21-5 APRACLONIDINE, 98.5%

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
    17 Walnut St., Tai Kok Tsui, Kln,
    Hong Kong ,Hong kong
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66711-21-5 Apraclonidine HCl

  • Apraclonidine HCl
  • China Shanghai Synnad Chemical Co., Ltd. [Importer/Exporter]
  • Tel: 86 21 5109 7911
  • Fax: 86 21 5109 7955
  • Address: B-5 Ecust Science Park, No. 18, Lane 1305, Hua Jing Road, Shanghai 200231 China Shanghai,ShanghaiChina
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66711-21-5 Apraclonidine HCl

  • Apraclonidine HCl
  • United States RIA International [Manufacturer]
  • Tel: 19735811282
  • Fax: 19735811283
  • Address: 11 Melanie Lane #17 East Hanover 07936 NJ UNITED STATES NJ,United States
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66711-21-5 Apraclonidine

  • Apraclonidine, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,China
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66711-21-5 Apraclonidine

  • China Shanghai Xunxin Chemical Co., Ltd [Manufacturers]
  • Tel: +86-(21)-38218795
  • Fax: +86-(21)-38218795
  • Address: 580 Lane, Kanghong Road, Pudong New District, Shanghai 201315, Shanghai,ShanghaiChina
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66711-21-5 Aplonidine Hydrochloride

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66711-21-5 Apraclonidine

  • China Haihang Industry Co., Ltd. []
  • Tel: +86-(531)-88032799
  • Fax: +86-(531)-85821093
  • Address: 2/F, East Tower, Bldg 12, No. 2 Qilihe Road, Jinan 250100, ,China
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66711-21-5 Apraclonidine

  • India Manus Aktteva []
  • Tel: +91-(79)-65123395
  • Fax: +91-(79)-26463395
  • Address: 303, 3rd Floor, Royale Manor, Law Garden, Dhulia Kot Road, Ellisbridge, Ahmedabad, Gujarat 380006, ,India
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66711-21-5 Apraclonidine

  • China Betapharma(Shanghai)Co., Ltd. []
  • Tel: +86-(21)-33538380
  • Fax: +86-(21)-32082820
  • Address: No.17#-6D. 830 Lane, Maotai Road, Shanghai 200336, ,China
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References of 2,6-dichloro-1-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine
Title: Apraclonidine
CAS Registry Number: 66711-21-5
CAS Name: 2,6-Dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)-1,4-benzenediamine
Synonyms: 2,6-dichloro-N¢-2-imidazolidinylidene-1,4-benzenediamine; 2-[(4-amino-2,6-dichlorophenyl)imino]imidazolidine; p-aminoclonidine; aplonidine
Manufacturers' Codes: NC-14
Molecular Formula: C9H10Cl2N4
Molecular Weight: 245.11
Percent Composition: C 44.10%, H 4.11%, Cl 28.93%, N 22.86%
Literature References: a2-Adrenergic agonist; structural analog of clonidine, q.v. Synthesis: B. Rouot, G. LeClerc, Bull. Soc. Chim. Fr. Pt. 2, 520 (1979). Prepn (not claimed) and use in treatment of intraocular pressure: B. M. York, Jr., US 4517199 (1985 to Alcon). Pharmacology: B. Rouot et al., C.R. Seances Acad. Sci. Ser. D 286, 909 (1978). Receptor binding studies: D. C. U'Prichard, Prog. Clin. Biol. Res. 71, 53 (1981). D. C. Stump, D. E. MacFarlane, J. Lab. Clin. Med. 102, 779 (1983). Clinical pharmacology: D. A. Abrams et al., Arch. Ophthalmol. 105, 1205 (1987). Clinical evaluation in treatment of intraocular pressure: A. L. Robin et al., ibid. 1208; as additive to maximally tolerated medical therapy in glaucoma: A. L. Robin et al., Am. J. Ophthalmol. 120, 423 (1995).
Properties: Solid, mp >230°.
Melting point: mp >230°
 
Derivative Type: Hydrochloride
CAS Registry Number: 73218-79-8
Manufacturers' Codes: ALO-2145
Trademarks: Iopidine (Alcon)
Molecular Formula: C9H10Cl2N4.HCl
Molecular Weight: 281.57
Percent Composition: C 38.39%, H 3.94%, Cl 37.77%, N 19.90%
 
Derivative Type: Dihydrochloride
CAS Registry Number: 73217-88-6
Molecular Formula: C9H10Cl2N4.2HCl
Molecular Weight: 318.03
Percent Composition: C 33.99%, H 3.80%, Cl 44.59%, N 17.62%
Properties: uv max (ethanol): 254, 304 nm (e 1800, 2500).
Absorption maximum: uv max (ethanol): 254, 304 nm (e 1800, 2500)
 
Therap-Cat: Treatment of post-surgical elevated intraocular pressure.
Keywords: a-Adrenergic Agonist; Antiglaucoma.