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CAS No 68-88-2 , 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]ethanol

  • Name: 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]ethanol
  • Synonyms: Hydroxycine; Hydroxizine; Atarax; Ataraxoid; Hydroxyzin;Hychotine;2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]ethanol; Atarazoid; Vistaril; Hydroxine;
  • CAS Registry Number:
  • Melting Point: 190 ºC
  • Boiling Point: 220 (0.5 torr)
  • Water Solubility: < 700 MG/ML
  • Safety Statements: Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. When heated to decomposition it emits very toxic fumes of Cl and NOx.
  • EINECS: 200-693-1
  • Molecular Weight: 374.90428
  • InchiKey: ZQDWXGKKHFNSQK-UHFFFAOYSA-N
  • InChI: InChI=1S/C21H27ClN2O2/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-
    23(11-13-24)14-16-26-17-15-25/h1-9,21,25H,10-17H2
  • Molecular Formula: C21H27ClN2O2
  • Molecular Structure:CAS No:68-88-2 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]ethanol
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68-88-2 EQUIPOISE / HYDROXYZINE

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
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    Hong Kong ,Hong kong
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68-88-2 Ethanol,2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-

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68-88-2 Hydroxyzine

  • IUPAC NAME-(±)-2-(2-{4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl}ethoxy)ethanol MOLECULAR FORMULA-C21H27ClN2O2 MOLAR MASS-374.904 g/mol Hydroxyzine is classified as an antihistamine, antipsychotic, anxiolytic and is also used as a tranquilizer; e...
  • India Swapnroop Drugs & Pharmaceuticals [Manufacturer, Trading Company]
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  • Address: Harsool Aurangabad,MaharashtraIndia

68-88-2 Hydroxyzine

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68-88-2 2-(2-(4-((4-Chlorophenyl)-Phenyl-Methyl)piperazin-...

  • China Simag Chemicals [Manufacturer]
  • Tel: +86 592 2680277
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  • Address: Simag Chemicals
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    Xiamen China. ,China
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68-88-2 Hydroxyzine

  • United States CBSCHEM LIMITED []
  • Fax: (888) 557-9843
  • Address: 621 South 48th Street, Suite 115,Tempe, AZ 85281 ,United States
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68-88-2 Ethanol,2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-

  • China NINGBO PANGS CHEM INT’L CO., LTD. [Manufacturers]
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  • Address: Floor 21, Building 11, Xintiandi, No. 689, Shijiroad, Ningbo, Zhejiang, China ,zhejiangChina
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68-88-2 Ethanol,2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-

  • China YANN PHARMACHEM []
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68-88-2 Hydroxyzine

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68-88-2 Ethanol,2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-

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References of 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]ethanol
Title: Hydroxyzine
CAS Registry Number: 68-88-2
CAS Name: 2-[2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]ethanol
Synonyms: 1-(p-chloro-a-phenylbenzyl)-4-(2-hydroxyethoxyethyl)piperazine; 1-(p-chlorodiphenylmethyl)-4-[2-(2-hydroxyethoxy)ethyl]piperazine; N-(4-chlorobenzhydryl)-N¢-(hydroxyethyloxyethyl)piperazine; 1-(p-chlorobenzhydryl)-4-[2-(2-hydroxyethoxy)ethyl]diethylenediamine
Manufacturers' Codes: UCB-4492
Trademarks: Tran-Q (Pfizer); Tranquizine
Molecular Formula: C21H27ClN2O2
Molecular Weight: 374.90
Percent Composition: C 67.28%, H 7.26%, Cl 9.46%, N 7.47%, O 8.54%
Literature References: H1 receptor antagonist. Outline of commercial prepn: Chem. Week 79 (5), 70 (Aug. 4, 1956); Morren, US 2899436 (1959 to UCB). Pharmacology and metabolism: Cannizaro, Boll. Chim. Farm. 104, 39 (1965); Close et al., Ind. Chim. Belge 33, 94 (1968); eidem, Proc. Eur. Soc. Study Drug Toxic. 9, 144 (1968); S. F. Pong, C. L. Huang, J. Pharm. Sci. 63, 1527 (1974). Pharmacokinetics and antihistaminic activity: F. E. R. Simons et al., J. Allergy Clin. Immunol. 73, 69 (1984); S. Ting et al., ibid. 75, 63 (1985). Clinical trials of efficacy in allergic rhinitis: L. Wong et al., ibid. 67, 223 (1981); in urticaria, R. P. Harvey et al., ibid. 68, 262 (1981); as anti-emetic: R. McKenzie et al., Anesth. Analg. 60, 783 (1981); as pre-surgical sedative: G. Wallace, L. J. Mindlin, ibid. 63, 571 (1984). Toxicity data: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971). Comprehensive description: J. Tsau, N. DeAngelis, Anal. Profiles Drug Subs. 7, 319-341 (1978).
 
Derivative Type: Dihydrochloride
CAS Registry Number: 2192-20-3
Trademarks: Alamon (Grelan); Atarax (Pfizer); Aterax; Durrax (Dermik); Orgatrax (Organon); Quiess (Forest); Vistaril Parenteral (Pfizer)
Molecular Formula: C21H27ClN2O2.2HCl
Molecular Weight: 447.83
Percent Composition: C 56.32%, H 6.53%, Cl 23.75%, N 6.26%, O 7.15%
Properties: Crystals, mp 193°. Bitter taste. Soly in mg/ml: water <700; chloroform 60; acetone 2; ether <0.1. Solns are unstable to intense uv light. LD50 in rats (mg/kg): 126 i.p.; 950 orally (Goldenthal).
Melting point: mp 193°
Toxicity data: LD50 in rats (mg/kg): 126 i.p.; 950 orally (Goldenthal)
 
Derivative Type: Pamoate
CAS Registry Number: 10246-75-0
Trademarks: Equipose; Masmoran (Pfizer); Paxistil; Vistaril Pamoate (Pfizer)
Molecular Formula: C21H27ClN2O2.C23H16O6
Molecular Weight: 763.27
Percent Composition: C 69.24%, H 5.68%, Cl 4.64%, N 3.67%, O 16.77%
Properties: Crystals. Practically insol in water.
 
Therap-Cat: Anxiolytic. Antihistaminic.
Therap-Cat-Vet: Has been used as a tranquilizer.
Keywords: Antihistaminic; Piperazines; Anxiolytic.