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CAS No 72492-12-7 , Spiro[benzofuran-2(3H),1'-cyclopropan]-3-one,5-acetyl-

  • Name: Spiro[benzofuran-2(3H),1'-cyclopropan]-3-one,5-acetyl-
  • Synonyms: AG 629;Maon; Spizofurone;Spiro[benzofuran-2(3H),1'-cyclopropan]-3-one,5-acetyl-;
  • CAS Registry Number:
  • Density: 1.33 g/cm3
  • Refractive index: 1.61
  • Safety Statements: Moderately toxic by ingestion, intraperitoneal and subcutaneous routes. When heated to decomposition it emits acrid smoke and irritating fumes.
  • Molecular Weight: 202.21
  • InChI: InChI=1/C12H10O3/c1-7(13)8-2-3-10-9(6-8)11(14)12(15-10)4-5-12/h2-3,6H,4-5H2,1H3
  • Molecular Formula: C12H10O3
  • Molecular Structure:CAS No:72492-12-7 Spiro[benzofuran-2(3H),1'-cyclopropan]-3-one,5-acetyl-

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References of Spiro[benzofuran-2(3H),1'-cyclopropan]-3-one,5-acetyl-
Title: Spizofurone
CAS Registry Number: 72492-12-7
CAS Name: 5-Acetylspiro[benzofuran-2(3H),1￠-cyclopropan]-3-one
Manufacturers' Codes: AG-629
Trademarks: Maon (Takeda)
Molecular Formula: C12H10O3
Molecular Weight: 202.21
Percent Composition: C 71.28%, H 4.98%, O 23.74%
Literature References: Prepn: H. Sugihara et al., EP 3084; eidem, US 4284644 (1979, 1981 both to Takeda); M. Kawada et al., Chem. Pharm. Bull. 32, 3532 (1984). One step synthesis: M. Watanabe et al., ibid. 3373. Anti-ulcerative effect in animals: N. Inatomi et al., Arzneim.-Forsch. 35, 1553 (1985). Cytoprotective effects on rat gastric mucosa: eidem, Eur. J. Pharmacol. 112, 81 (1985). Stimulation of endogenous prostaglandin synthesis in vitro: I. Inada et al., ibid. 124, 149 (1986).
Properties: Crystals from ethanol, mp 102-104° (Kawada); also reported as mp 106-107° (Watanabe).
Melting point: mp 102-104° (Kawada); mp 106-107° (Watanabe)
Therap-Cat: Antiulcerative.
Keywords: Antiulcerative; Cytoprotectant (Gastric).
 
 
Status: This monograph has been retired and is no longer subject to revision or update.