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CAS No 7456-24-8 , 10-[2-(dimethylamino)propyl]-N,N-dimethylphenothiazine-2-sulfonamide

  • Name: 10-[2-(dimethylamino)propyl]-N,N-dimethylphenothiazine-2-sulfonamide
  • Synonyms: 10-[2-(dimethylamino)propyl]-N,N-dimethylphenothiazine-2-sulfonamide;Dimethothiazine; Dimetotiazinum [INN-Latin]; Bayer 1483; Dimethodin; Dimetiotazine; Dimetotiazine; Dimetotiazine [INN:BAN];
  • CAS Registry Number:
  • Flash Point: 276.6°C
  • Boiling Point: 533.7°C at 760 mmHg
  • Density: 1.235g/cm3
  • Refractive index: 1.612
  • Safety Statements: Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx and SOx.
  • Flash Point: 276.6°C
  • EINECS: 231-229-6
  • Molecular Weight: 391.5507
  • InchiKey: VWNWVCJGUMZDIU-UHFFFAOYSA-N
  • InChI: InChI=1S/C19H25N3O2S2/c1-14(20(2)3)13-22-16-8-6-7-9-18(16)25-19-11-10-15
    (12-17(19)22)26(23,24)21(4)5/h6-12,14H,13H2,1-5H3
  • Molecular Formula: C19H25N3O2S2
  • Molecular Structure:CAS No:7456-24-8 10-[2-(dimethylamino)propyl]-N,N-dimethylphenothiazine-2-sulfonamide

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References of 10-[2-(dimethylamino)propyl]-N,N-dimethylphenothiazine-2-sulfonamide
Title: Fonazine
CAS Registry Number: 7456-24-8
CAS Name: 10-[2-(Dimethylamino)propyl]-N,N-dimethyl-10H-phenothiazine-2-sulfonamide
Synonyms: 10-(2-dimethylaminopropyl)-3-dimethylsulfamidophenothiazine; 3-dimethylsulfamido-10-(2-dimethylaminopropyl)phenothiazine; dimethothiazine; dimethiotazine; dimetiotazine
Manufacturers' Codes: RP-8599
Molecular Formula: C19H25N3O2S2
Molecular Weight: 391.55
Percent Composition: C 58.28%, H 6.44%, N 10.73%, O 8.17%, S 16.38%
Literature References: Serotonin inhibitor. Prepn: GB 814512 (1959 to Rh?ne-Poulenc). Pharmacokinetics and distribution in dog and rat: O. R. W. Lewellen, R. Templeton, Adv. Biochem. Psychopharmacol. 9, 213 (1974). Clinical evaluation in spasticity: W. B. Matthews et al., Acta Neurol. Scand. 48, 635 (1972). HPLC determn in plasma: J. Holt et al., Br. J. Clin. Pharmacol. 13, 282 (1982).
 
Derivative Type: Hydrochloride
Molecular Formula: C19H25N3O2S2.HCl
Molecular Weight: 428.01
Percent Composition: C 53.32%, H 6.12%, N 9.82%, O 7.48%, S 14.98%, Cl 8.28%
Properties: Crystals, dec 214°.
 
Derivative Type: Methanesulfonate
CAS Registry Number: 7455-39-2
Synonyms: Dimethothiazine mesylate; fonazine mesylate
Trademarks: Banistyl (M & B); Bonpac (Hoei); Calsekin (Mect); Migristène (Specia); Neomestine (Taiyo); Promaquid (Rh>e-Poulenc); Yoristen (Kodama)
Molecular Formula: C19H25N3O2S2.CH3SO3H
Molecular Weight: 487.66
Percent Composition: C 49.26%, H 5.99%, N 8.62%, O 16.40%, S 19.73%
 
Therap-Cat: Antimigraine.
Keywords: Antimigraine.