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CAS No 76568-02-0 , 7-fluoro-1-methyl-3-methylsulfinylquinolin-4-one

  • Name: 7-fluoro-1-methyl-3-methylsulfinylquinolin-4-one
  • Synonyms: Flosequinan (USAN/INN); NCGC00183849-01;Manoplax; AC1NBUQ7;7-fluoro-1-methyl-3-methylsulfinylquinolin-4-one; BTS-49465; SureCN122877; 76568-02-0;
  • CAS Registry Number:
  • Flash Point: 209.7°C
  • Boiling Point: 423.1°C at 760 mmHg
  • Density: 1.44g/cm3
  • Refractive index: 1.654
  • Flash Point: 209.7°C
  • Molecular Weight: 239.266003
  • InchiKey: UYGONJYYUKVHDD-UHFFFAOYSA-N
  • InChI: InChI=1S/C11H10FNO2S/c1-13-6-10(16(2)15)11(14)8-4-3-7(12)5-9(8)13/h3-6H,
    1-2H3
  • Molecular Formula: C11H10FNO2S
  • Molecular Structure:CAS No:76568-02-0 7-fluoro-1-methyl-3-methylsulfinylquinolin-4-one
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76568-02-0 FLOSEQUINAN

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
    17 Walnut St., Tai Kok Tsui, Kln,
    Hong Kong null,nullHong kong
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76568-02-0 Flosequinan

  • Flosequinan, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,nullChina
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76568-02-0 Flosequinan

  • Flosequinan, 99%
  • China Facus Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-(0)574-62378411
  • Fax: +86-(0)574-62378410
  • Address: 24Fl,Yuanjing Building,Beilun District, Zhejiang 315800 NingboCHINA Ningbo,nullChina
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76568-02-0 Flosequinan

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76568-02-0 Flosequinan

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 null,nullUnited States
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76568-02-0 FLOSEQUINAN

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76568-02-0 Flosequinan

  • Flosequinan
  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
    Werner-von-Siemensstr. 3
    93128 Regenstauf
    Germany null,nullGermany
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76568-02-0 FLOSEQUINAN

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China null,nullChina
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References of 7-fluoro-1-methyl-3-methylsulfinylquinolin-4-one
Title: Flosequinan
CAS Registry Number: 76568-02-0
CAS Name: 7-Fluoro-1-methyl-3-(methylsulfinyl)-4(1H)-quinolinone
Synonyms: flosequinon
Manufacturers' Codes: BTS-49465
Trademarks: Manoplax (Boots)
Molecular Formula: C11H10FNO2S
Molecular Weight: 239.27
Percent Composition: C 55.22%, H 4.21%, F 7.94%, N 5.85%, O 13.37%, S 13.40%
Literature References: Mixed arterial and venous vasodilator. Prepn: R. V. Davies et al., DE 3011994; eidem, US 4302460 (1980, 1981 both to Boots). Pharmacology: J. G. Smith, G. T. Kinasewitz, J. Cardiovasc. Pharmacol. 8, 878 (1986); M. F. Sim et al., Br. J. Pharmacol. 94, 371 (1988). HPLC determn in plasma, serum and urine: M. B. Slegowski et al., J. Chromatogr. 425, 227 (1988). Pharmacokinetics and hemodynamics in humans: A. J. Cowley et al., J. Hypertens. 2, Suppl. 3, 547 (1984); R. D. Wynne et al., Eur. J. Clin. Pharmacol. 28, 659 (1985). Preliminary evaluation in hypertension: A. J. Cowley et al., ibid. 33, 203 (1987); in congestive heart failure: P. D. Kessler, M. Packer, Am. Heart J. 113, 137 (1987); P. D. Kessler et al., J. Cardiovasc. Pharmacol. 12, 6 (1988). Clinical study in chronic heart failure: A. J. Cowley et al., Br. Med. J. 297, 169 (1988).
Properties: Crystals, mp 226-228°.
Melting point: mp 226-228°
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive.