Title: Phenyl Dichlorophosphate
CAS Registry Number: 770-12-7
CAS Name: Phosphorodichloridic acid phenyl ester
Synonyms: PCDP
Molecular Formula: C6H5Cl2O2P
Molecular Weight: 210.98
Percent Composition: C 34.16%, H 2.39%, Cl 33.61%, O 15.17%, P 14.68%
Literature References: Phosphorylation reagent. Prepn: G. Jacobsen,
Ber. 8, 1519 (1875); R. Anschütz, W. O Emery,
Ann. 253, 105 (1889). Activation of carboxyl groups: H.-J. Liu, S. I. Sabesan,
Can. J. Chem. 58, 2645 (1980); for lactam synthesis: J. M. Aizpurua
et al., Tetrahedron Lett. 25, 3905 (1984); L. Banfi, G. Guanti,
ibid. 43, 7427 (2002). Oxidative rearrangements: H.-J. Liu, J. M. Nyangulu,
ibid. 30, 5097 (1989); J. P. Jeyadevan
et al., J. Med. Chem. 47, 1290 (2004). Brief review: A. K. Adak,
Synlett 2004, 1651-1652.
Properties: Liquid, bp9mmHg 103-106°; bp13-14mm 116°. d420 1.41214.
Boiling point: Liquid, bp9mmHg 103-106°; bp13-14mm 116°
Density: d420 1.41214
Use: In organic synthesis for preparation of lactams, phosphate diesters and for oxidation reactions.
