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CAS No 78110-38-0 , Aztreonam

  • Name: Aztreonam
  • Synonyms: Aztreonam;[2s-[2a,3b(z)]]-2-[[[1-(2-amino-4-thiazolyl)-2-[(2-methyl-4-oxo-1-sulfo-3-azetidinyl)amino]-2-oxoethylidene]amino]oxy]-2-methylpropanoic acid;
  • CAS Registry Number:
  • Density: 1.83
  • Safety Statements: S22;S24/25
  • Hazard Symbols: Xn
  • EINECS: 278-839-9
  • Molecular Weight: 435.43
  • InChI: InChI=1/C13H17N5O8S2/c1-5-7(10(20)18(5)28(23,24)25)16-9(19)8(6-4-27-12(14)15-6)17-26-13(2,3)11(21)22/h4-5,7H,1-3H3,(H2,14,15)(H,16,19)(H,21,22)(H,23,24,25)/b17-8-/t5-,7-/m0/s1
  • Risk Statements: S22,S24/25,
  • Molecular Formula: C13H17N5O8S2
  • Molecular Structure:CAS No:78110-38-0 Aztreonam

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References of Aztreonam
Title: Aztreonam
CAS Registry Number: 78110-38-0
CAS Name: [2S-[2a,3b(Z)]]-2-[[[1-(2-Amino-4-thiazolyl)-2-[(2-methyl-4-oxo-1-sulfo-3-azetidinyl)amino]-2-oxoethylidene]amino]oxy]-2-methylpropanoic acid
Synonyms: azthreonam
Manufacturers' Codes: SQ-26776
Trademarks: Azactam (BMS); Primbactam (Menarini)
Molecular Formula: C13H17N5O8S2
Molecular Weight: 435.43
Percent Composition: C 35.86%, H 3.94%, N 16.08%, O 29.40%, S 14.73%
Literature References: The first totally synthetic monocyclic b-lactam (monobactam) antibiotic. It has a high degree of resistance to b-lactamases and shows specific activity vs aerobic gram-negative rods. Prepn: R. B. Sykes et al., NL 8100571 (1981 to Squibb), C.A. 96, 181062x (1982). Fast-atom-bombardment mass spectra: A. I. Cohen et al., J. Pharm. Sci. 71, 1065 (1982). Activity vs gram-negative bacteria: R. B. Sykes et al., Antimicrob. Agents Chemother. 21, 85 (1982). Series of articles on structure-activity, in vitro and in vivo properties, pharmacokinetics: J. Antimicrob. Chemother. 8, Suppl. E, 1-148 (1981). Toxicology: G. R. Keim et al., ibid. 141. Mechanism of action study: A. D. Russell, J. R. Furr, ibid. 9, 329 (1982). Comparative stability to renal dipeptidase: H. Mikami et al., Antimicrob. Agents Chemother. 22, 693 (1982). Human pharmacokinetics: E. A. Swabb et al., ibid. 21, 944 (1982). Clinical evaluation in urinary tract infection: C. Donadio et al., Drugs Exp. Clin. Res. 13, 167 (1987). Clinical efficacy in neonatal sepsis: S. Sklavunu-Tsurutsoglu et al., Rev. Infect. Dis. 13, Suppl. 7, S591 (1991). Comprehensive description: K. Florey, Anal. Profiles Drug Subs. 17, 1-39 (1988).
Properties: White crystalline, odorless powder, dec 227°. Very slightly sol in ethanol, slightly sol in methanol, sol in DMF, DMSO. Practically insol in toluene, chloroform, ethyl acetate.
 
Derivative Type: Disodium salt
Molecular Formula: C13H15N5Na2O8S2
Molecular Weight: 479.40
Percent Composition: C 32.57%, H 3.15%, N 14.61%, Na 9.59%, O 26.70%, S 13.38%
Properties: LD50 (mg/kg): 3300 i.v. in mice; 6600 i.p. in rats (Keim).
Toxicity data: LD50 (mg/kg): 3300 i.v. in mice; 6600 i.p. in rats (Keim)
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Monobactams.