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CAS No 80-08-0 , 4-(4-aminophenyl)sulfonylaniline

  • Name: 4-(4-aminophenyl)sulfonylaniline
  • Synonyms: Sulfadione; Diaphenylsulfon; 80-08-0;4-(4-aminophenyl)sulfonylaniline; Sulfona; 4,4'-Diaminodiphenyl sulfone; Avlosulfone;Diaphenylsulfone; Diphenasone;
  • CAS Registry Number:
  • Transport: UN 3249
  • Melting Point: 173-178 ºC
  • Flash Point: 263.2 ºC
  • Boiling Point: 511.7 ºC at 760 mmHg
  • Density: 1.361 g/cm3
  • Water Solubility: <0.1 G/100 ML AT 20 ºC
  • Safety Statements: R22
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 263.2 ºC
  • EINECS: 201-248-4
  • Molecular Weight: 248.30088
  • InchiKey: MQJKPEGWNLWLTK-UHFFFAOYSA-N
  • InChI: InChI=1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,
    16)12-7-3-10(14)4-8-12/h1-8H,13-14H2
  • Risk Statements: S22
  • Molecular Formula: C12H12N2O2S
  • Molecular Structure:CAS No:80-08-0 4-(4-aminophenyl)sulfonylaniline

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References of 4-(4-aminophenyl)sulfonylaniline
Title: Dapsone
CAS Registry Number: 80-08-0
CAS Name: 4,4￠-Sulfonylbisbenzeneamine
Synonyms: 4,4￠-sulfonyldianiline; bis(4-aminophenyl)sulfone; 4,4￠-diaminodiphenyl sulfone; DDS; diaphenylsulfone; DADPS
Manufacturers' Codes: 1358F
Trademarks: Avlosulfon (Wyeth-Ayerst); Croysulfone; Diphenasone; Disulone (Specia); Dumitone; Eporal; Novophone; Sulfona-Mae; Sulphadione; Udolac (Mallinckrodt)
Molecular Formula: C12H12N2O2S
Molecular Weight: 248.30
Percent Composition: C 58.05%, H 4.87%, N 11.28%, O 12.89%, S 12.91%
Literature References: Prepn: FR 829926 (1938 to I. G. Farbenind.), C.A. 33, 1761 (1939); Buckles, J. Chem. Educ. 31, 36 (1954); Ferry et al., Org. Synth. coll. vol. III, 239 (1955). Antibacterial action and metabolism: J. Francis, A. Spinks, Br. J. Pharmacol. 5, 565 (1950). Mechanism of toxic action: Wu, DuBois, Arch. Int. Pharmacodyn. Ther. 183, 36 (1970). Comprehensive description: C. E. Orzech et al., Anal. Profiles Drug Subs. 5, 87-114 (1976). Review of pharmacology and therapeutic use: J. Uetrecht, Clin. Dermatol. 7, 111-120 (1989). Clinical trial with chlorproguanil, q.v., in drug-resistant malaria: T. Mutabingwa et al., Lancet 358, 1218 (2001).
Properties: Crystals from 95% ethanol. mp 175-176° (also a higher melting form, mp 180.5°). pKb 13.0. Soluble in alcohol, methanol, acetone, dil hydrochloric acid. Practically insol in water.
Melting point: mp 175-176° (also a higher melting form, mp 180.5°)
pKa: pKb 13.0
Use: Hardening agent in the curing of epoxy resins.
Therap-Cat: Antibacterial (leprostatic); in treatment of dermatitis herpetiformis.
Therap-Cat-Vet: Antibacterial; coccidostat.
Keywords: Antibacterial (Synthetic); Sulfones; Antibacterial (Leprostatic); Dermatitis Herpetiformis Suppressant.