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CAS No 80-92-2 , Pregnane-3,20-diol, (3a,5b,20S)-

  • Name: Pregnane-3,20-diol, (3a,5b,20S)-
  • Synonyms: Pregnane-3,20-diol, (3a,5b,20S)-; Diol (6CI,7CI); Pregnanediol; NSC 1612;5b-Pregnane-3a,20a-diol (8CI); 3a,20a-Dihydroxy-5b-pregnane; NSC 47462;
  • CAS Registry Number:
  • Flash Point: 191°C
  • Boiling Point: 435.9°C at 760 mmHg
  • Density: 1.053g/cm3
  • Refractive index: 1.531
  • Safety Statements:
    RTECS TU4157113
  • Flash Point: 191°C
  • EINECS: 201-313-7
  • Molecular Weight: 320.51
  • InChI: InChI=1/C21H36O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h13-19,22-23H,4-12H2,1-3H3/t13-,14-,15-,16-,17-,18-,19-,20+,21-/m0/s1
  • Molecular Formula: C21H36 O2
  • Molecular Structure:CAS No:80-92-2 Pregnane-3,20-diol, (3a,5b,20S)-
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80-92-2 5SS-PREGNANE-3ALPHA,20ALPHA-DIOL; 98%

  • Germany ABCR GmbH & Co KG [Manufacturer]
  • Tel: +49 721 95061-0
  • Fax: +49 721 95061-80
  • Address: Im Schlehert 10
    76187 Karlsruhe
    Germany null,nullGermany
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80-92-2 5BETA-PREGNANE-3ALPHA,20ALPHA-DIOL

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China null,nullChina
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80-92-2 PREGNANEDIOL(RG)

  • United States ChromaDex Inc. [Manufacturer]
  • Tel: 949-419-0288
  • Fax: 949-419-0294
  • Address: ChromaDex Inc.
    10005 Muirlands Blvd. Suite G - First Floor
    Irvine, CA 92618 null,nullUnited States
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80-92-2 5BETA-PREGNANE-3ALPHA 20ALPHA-DIOL 98+%

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
    17 Walnut St., Tai Kok Tsui, Kln,
    Hong Kong null,nullHong kong
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References of Pregnane-3,20-diol, (3a,5b,20S)-
Title: Pregnanediol
CAS Registry Number: 80-92-2
CAS Name: (3a,5b,20S)-Pregnane-3,20-diol
Molecular Formula: C21H36O2
Molecular Weight: 320.51
Percent Composition: C 78.69%, H 11.32%, O 9.98%
Literature References: A metabolite of progesterone, present in large amounts in pregnancy urine. Isoln from pregnancy urine of women: Marrian, Biochem. J. 23, 1090 (1929), Butenandt, Ber. 63, 659 (1930); of cows, mares, and chimpanzees: Fish et al., J. Biol. Chem. 143, 716 (1942). Prepn by reduction of pregn-16-ene-3,20-dione: Marker et al., US 2352852 (1944 to Parke, Davis). Conversion to progesterone: Butenandt, Schmidt, Ber. 67, 1893, 1901 (1934). Conversion to 3a-hydroxypregnan-20-one: Marker, US 2223377 (1940 to Parke, Davis). Prepn of the 3-acetate: Hirschmann, J. Biol. Chem. 140, 797 (1941); Ralls et al., ibid. 210, 709 (1954). Prepn of the 20-acetate: Hirschmann, loc. cit. Prepn of the diacetate: Johnson et al., J. Chem. Soc. 1954, 1302. Crystal structure: Haner, Norton, Acta Crystallogr. 16, 707 (1963). Review of metabolism, bioactivity and assay during pregnancy: P. J. Keller, Contrib. Gynecol. Obstet. 2, 75-91 (1976).
Properties: Crystals from acetone or ethanol, mp 239°. [a]D20 +27.4° (c = 0.7 in alc). Sparingly sol in organic solvents. Not precipitated by digitonin.
Melting point: mp 239°
Optical Rotation: [a]D20 +27.4° (c = 0.7 in alc)
 
Derivative Type: 3-Acetate
Synonyms: 3a-Acetoxypregnan-20a-ol
Molecular Formula: C23H38O3
Molecular Weight: 362.55
Percent Composition: C 76.20%, H 10.56%, O 13.24%
Properties: Crystals, mp 132°. [a]D25 +45° (CHCl3).
Melting point: mp 132°
Optical Rotation: [a]D25 +45° (CHCl3)
 
Derivative Type: 20-Acetate
Synonyms: 20a-Acetoxypregnan-3a-ol
Molecular Formula: C23H38O3
Molecular Weight: 362.55
Percent Composition: C 76.20%, H 10.56%, O 13.24%
Properties: Crystals, mp 174°.
Melting point: mp 174°
 
Derivative Type: Diacetate
Synonyms: 3a,20a-Diacetoxypregnane
Molecular Formula: C25H40O4
Molecular Weight: 404.58
Percent Composition: C 74.22%, H 9.97%, O 15.82%
Properties: Crystals from light petroleum, mp 180°, also reported as mp 182-183°. [a]D15 +35° (c = 1.1 in CHCl3).
Melting point: mp 180°; mp 182-183°
Optical Rotation: [a]D15 +35° (c = 1.1 in CHCl3)
 
Use: In manuf of progesterone.